Inhibition of H1N1 influenza virus-induced apoptosis by selenium nanoparticles functionalized with arbidol through ROS-mediated signaling pathways

2019 ◽  
Vol 7 (27) ◽  
pp. 4252-4262 ◽  
Author(s):  
Yinghua Li ◽  
Zhengfang Lin ◽  
Guifang Gong ◽  
Min Guo ◽  
Tiantian Xu ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Signaling Pathways ◽  
Clinical Application ◽  
Antiviral Agent ◽  
H1n1 Influenza ◽  
Selenium Nanoparticles ◽  
Drug Resistant ◽  
H1n1 Influenza Virus ◽  
Induced Apoptosis

As an effective antiviral agent, the clinical application of arbidol is limited by the appearance of drug-resistant viruses.

scholarly journals Inhibition of H1N1 influenza virus by selenium nanoparticles loaded with zanamivir through p38 and JNK signaling pathways

RSC Advances ◽  
2017 ◽  
Vol 7 (56) ◽  
pp. 35290-35296 ◽  
Author(s):  
Zhengfang Lin ◽  
Yinghua Li ◽  
Min Guo ◽  
Misi Xiao ◽  
Changbing Wang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Signaling Pathways ◽  
Clinical Application ◽  
Influenza Virus Infection ◽  
Aqueous Solubility ◽  
H1n1 Influenza ◽  
Solubility Limit ◽  
H1n1 Influenza Virus ◽  
Jnk Signaling

Zanamivir is an effective drug for influenza virus infection, but strong molecular polarity and aqueous solubility limit its clinical application.

scholarly journals The Inhibition of H1N1 influenza virus-induced apoptosis by functionalized Selenium nanoparticles with β-Thujaplicin through ROS-mediated P53 and AKT signaling pathways

2020 ◽  
Author(s):  
Changbing Wang ◽  
Mingqi Zhao ◽  
Zhengfang Lin ◽  
Min Guo ◽  
Tiantian Xu ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Signaling Pathways ◽  
Mdck Cells ◽  
Biological Activities ◽  
Chromatin Condensation ◽  
H1n1 Influenza ◽  
Selenium Nanoparticles ◽  
H1n1 Influenza Virus ◽  
Biomedical Intervention ◽  
Mechanistic Investigation

Abstract β-Thujaplicin possess a variety of biological activities. The use of modified biological nanoparticles (NPs) to develop novel anti-influenza drugs has increased in recent years. Selenium nanoparticles (SeNPs) with antiviral has attracted increasing attention for biomedical intervention. Functionalized SeNPs by β-Thujaplicin (Se@TP) surface modified with superior antiviral were synthesized in this study. β-Thujaplicin decoration of SeNPs obviously inhibited H1N1 infection and were less toxicity. Se@TP could inhibit H1N1 from infecting Madin Darby Canine Kidney (MDCK) cells and block chromatin condensation and DNA fragmentation. Se@TP obviously prevented MDCK cells from generating reactive oxygen species (ROS). Furthermore, Se@TP prevent lung injury in H1N1 infected mice through eosin staining and hematoxylin in vivo . Additionally, when treated with Se@TP, the DNA damage of lung tissues reduced substantially by TUNEL-DAPI test. Mechanistic investigation revealed that Se@TP inhibited H1N1 influenza virus from infecting MDCK cells through induction of apoptosis via suppression AKT and p53 signaling pathways through Immunohistochemical assay. Our results suggest that β-Thujaplicin modified SeNPs as carriers is an efficient way to achieve antiviral pharmaceutical candidate for H1N1 influenza.

scholarly journals The inhibition of H1N1 influenza virus-induced apoptosis by silver nanoparticles functionalized with zanamivir

RSC Advances ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 742-750 ◽  
Author(s):  
Zhengfang Lin ◽  
Yinghua Li ◽  
Min Guo ◽  
Tiantian Xu ◽  
Changbing Wang ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Influenza Virus ◽  
Virus Infection ◽  
Clinical Application ◽  
Influenza Virus Infection ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus ◽  
Induced Apoptosis ◽  
Effective Drugs

As one of the most effective drugs for influenza virus infection, clinical application of zanamivir is restricted with the emergence of resistant influenza virus.

scholarly journals Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus

2017 ◽  
Vol Volume 12 ◽  
pp. 5733-5743 ◽  
Author(s):  
Yinghua Li ◽  
Zhengfang Lin ◽  
Min Guo ◽  
Yu Xia ◽  
Mingqi Zhao ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Inhibitory Activity ◽  
H1n1 Influenza ◽  
Selenium Nanoparticles ◽  
H1n1 Influenza Virus

Silver Nanoparticle Based Codelivery of Oseltamivir to Inhibit the Activity of the H1N1 Influenza Virus through ROS-Mediated Signaling Pathways

2016 ◽  
Vol 8 (37) ◽  
pp. 24385-24393 ◽  
Author(s):  
Yinghua Li ◽  
Zhengfang Lin ◽  
Mingqi Zhao ◽  
Tiantian Xu ◽  
Changbing Wang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Signaling Pathways ◽  
Silver Nanoparticle ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus

Reversal of H1N1 influenza virus-induced apoptosis by silver nanoparticles functionalized with amantadine

RSC Advances ◽  
2016 ◽  
Vol 6 (92) ◽  
pp. 89679-89686 ◽  
Author(s):  
Yinghua Li ◽  
Zhengfang Lin ◽  
Mingqi Zhao ◽  
Min Guo ◽  
Tiantian Xu ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Influenza Virus ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus ◽  
Induced Apoptosis

Reversal of H1N1 influenza virus-induced apoptosis by silver nanoparticles functionalized with amantadine.

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