Electrochemical protein recognition based on macromolecular self-assembly of molecularly imprinted polymer: a new strategy to mimic antibody for label-free biosensing

2019 ◽  
Vol 7 (14) ◽  
pp. 2311-2319 ◽  
Author(s):  
Wei Zhao ◽  
Bing Li ◽  
Sheng Xu ◽  
Xuewen Huang ◽  
Jing Luo ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Self Assembly ◽  
Amphiphilic Copolymer ◽  
Protein Recognition ◽  
Label Free ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
New Strategy ◽  
Mip Sensor

A versatile strategy, based on the use of an amphiphilic copolymer as a macromonomer, was developed for the preparation of a fully synthetic MIP sensor for protein recognition

scholarly journals A new strategy for accelerated extraction of target compounds using molecularly imprinted polymer particles embedded in a paper-based disk

2017 ◽  
Vol 31 (3) ◽  
pp. e2629 ◽  
Author(s):  
Mashaalah Zarejousheghani ◽  
Steffi Schrader ◽  
Monika Möder ◽  
Matthias Schmidt ◽  
Helko Borsdorf
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Polymer Particles ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
New Strategy

scholarly journals A label-free detection of diethylstilbestrol based on molecularly imprinted polymer-coated upconversion nanoparticles obtained by surface grafting

RSC Advances ◽  
2017 ◽  
Vol 7 (36) ◽  
pp. 22215-22221 ◽  
Author(s):  
Yu Wang ◽  
Shuyue Ren ◽  
Huicong Jiang ◽  
Yuan Peng ◽  
Jialei Bai ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Fluorescent Sensor ◽  
Upconversion Nanoparticles ◽  
Surface Grafting ◽  
The Novel ◽  
Label Free ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Real Samples ◽  
Label Free Detection

The novel MIPs-coated UCNPs fluorescent sensor could be used for on-field detection of diethylstilbestrol in real samples.

scholarly journals Redesigning an Electrochemical MIP Sensor for PFOS: Practicalities and Pitfalls

Sensors ◽  
2019 ◽  
Vol 19 (20) ◽  
pp. 4433 ◽  
Author(s):  
Giulia Moro ◽  
Davide Cristofori ◽  
Fabio Bottari ◽  
Elti Cattaruzza ◽  
Karolien De Wael ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Electrochemical Sensors ◽  
Differential Pulse ◽  
Complete Characterization ◽  
In Situ Monitoring ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Heterogeneous Distribution ◽  
Molecularly Imprinted ◽  
Mip Sensor

There is a growing interest in the technological transfer of highly performing electrochemical sensors within portable analytical devices for the in situ monitoring of environmental contaminants, such as perfluorooctanesulfonic acid (PFOS). In the redesign of biomimetic sensors, many parameters should be taken into account from the working conditions to the electrode surface roughness. A complete characterization of the surface modifiers can help to avoid time-consuming optimizations and better interpret the sensor responses. In the present study, a molecularly imprinted polymer electrochemical sensor (MIP) for PFOS optimized on gold disk electrodes was redesigned on commercial gold screen-printed electrodes. However, its performance investigated by differential pulse voltammetry was found to be poor. Before proceeding with further optimization, a morphological study of the bare and modified electrode surfaces was carried out by scanning electron microscopy–energy-dispersive X-ray spectrometry (SEM–EDS), atomic force microscopy (AFM) and profilometry revealing an heterogeneous distribution of the polymer strongly influenced by the electrode roughness. The high content of fluorine of the target-template molecule allowed to map the distribution of the molecularly imprinted polymer before the template removal and to define a characterization protocol. This case study shows the importance of a multi-analytical characterization approach and identify significant parameters to be considered in similar redesigning studies.

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