scholarly journals The sensitivity of Cu for electrochemical carbon dioxide reduction to hydrocarbons as revealed by high throughput experiments

2019 ◽  
Vol 7 (47) ◽  
pp. 26785-26790
Author(s):  
Yungchieh Lai ◽  
Ryan J. R. Jones ◽  
Yu Wang ◽  
Lan Zhou ◽  
Matthias H. Richter ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
High Throughput ◽  
High Sensitivity ◽  
Carbon Dioxide Reduction ◽  
Product Selectivity ◽  
High Throughput Experiments

The uniqueness of Cu for CO2 electroreduction is accompanied by high sensitivity to contaminants, but alloys can tune product selectivity.

scholarly journals The Sensitivity of Cu for Electrochemical Carbon Dioxide Reduction to Hydrocarbons as Revealed by High Throughput Experiments

2019 ◽  
Author(s):  
Yunchieh Lai ◽  
Ryan J. R. Jones ◽  
Yu Wang ◽  
Lan Zhou ◽  
Matthias Richter ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
High Throughput ◽  
Co2 Reduction ◽  
Carbon Dioxide Reduction ◽  
Energy Technologies ◽  
Electrochemical Co2 Reduction ◽  
Segregation Of Alloying Elements ◽  
Hydrocarbon Formation ◽  
High Throughput Experiments ◽  
Alloy Concentration

Electrochemical CO2 reduction to valuable products is a centerpiece of future energy technologies that relies on identificaiton of new catalysts. We present accelerated screening of Cu bimetallic alloys, revealing remarkable sensitivity to alloy concentration that indicates the segregation of alloying elements to critical sites for hydrocarbon formation.

scholarly journals The Sensitivity of Cu for Electrochemical Carbon Dioxide Reduction to Hydrocarbons as Revealed by High Throughput Experiments

2019 ◽  
Author(s):  
Yunchieh Lai ◽  
Ryan J. R. Jones ◽  
Yu Wang ◽  
Lan Zhou ◽  
Matthias Richter ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
High Throughput ◽  
Co2 Reduction ◽  
Carbon Dioxide Reduction ◽  
Energy Technologies ◽  
Electrochemical Co2 Reduction ◽  
Segregation Of Alloying Elements ◽  
Hydrocarbon Formation ◽  
High Throughput Experiments ◽  
Alloy Concentration

Electrochemical CO2 reduction to valuable products is a centerpiece of future energy technologies that relies on identificaiton of new catalysts. We present accelerated screening of Cu bimetallic alloys, revealing remarkable sensitivity to alloy concentration that indicates the segregation of alloying elements to critical sites for hydrocarbon formation.

Selective electroreduction of CO2 to carbon-rich products with a simple binary copper selenide electrocatalyst

2021 ◽  
Author(s):  
Apurv Saxena ◽  
Wipula Liyanage ◽  
Jahangir Masud ◽  
Shubhender Kapila ◽  
Manashi Nath
Keyword(s):  
Carbon Dioxide ◽  
Carbon Dioxide Reduction ◽  
Copper Selenide ◽  
Product Selectivity

Simple, binary Cu2Se has been reported for electrocatalytic carbon dioxide reduction leading to the production of carbon rich products at low applied potentials with high product selectivity.

Ligand-Controlled Product Selectivity in Electrochemical Carbon Dioxide Reduction Using Manganese Bipyridine Catalysts

2020 ◽  
Vol 142 (9) ◽  
pp. 4265-4275 ◽  
Author(s):  
Magnus H. Rønne ◽  
Dasol Cho ◽  
Monica R. Madsen ◽  
Joakim B. Jakobsen ◽  
Seunghwan Eom ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Carbon Dioxide Reduction ◽  
Product Selectivity

scholarly journals Predicting functional long non-coding RNAs validated by low throughput experiments

2019 ◽  
Author(s):  
Bailing Zhou ◽  
Yuedong Yang ◽  
Jian Zhan ◽  
Xianghua Dou ◽  
Jihua Wang ◽  
...  
Keyword(s):  
High Throughput ◽  
High Sensitivity ◽  
Support Vector ◽  
Mrna Levels ◽  
Active Subject ◽  
Speed Up ◽  
Non Coding Rnas ◽  
Similar Accuracy ◽  
The Cost ◽  
High Throughput Experiments

ABSTRACTHigh-throughput techniques have uncovered hundreds and thousands of long non-coding RNAs (lncRNAs). Among them, only a small fraction has experimentally validated functions (EVlncRNAs) by low-throughput methods. What fraction of lncRNAs from high-throughput experiments (HTlncRNAs) is truly functional is an active subject of debate. Here, we developed the first method to distinguish EVlncRNAs from HTlncRNAs and mRNAs by using Support Vector Machines and found that EVlncRNAs can be well separated from HTlncRNAs and mRNAs with 0.6 for Matthews correlation coefficient, 64% for sensitivity, and 81% for precision for the independent human test set. The most discriminative features are related to sequence conservations at RNA (for separating from HTlncRNAs) and protein (for separating from mRNA) levels. The method is found to be robust as the human-RNA-trained model is applicable to independent mouse RNAs with similar accuracy and to a lesser extent to plant RNAs. The method can recover newly discovered EVlncRNAs with high sensitivity. Its application to randomly selected 2000 human HTlncRNAs indicates that a large number of functional lncRNAs are waiting to be validated. The method is expected to speed up and reduce the cost of the discovery by prioritizing potentially functional lncRNAs prior to experimental validation. EVlncRNA-pred is available as a web server at http://biophy.dzu.edu.cn/lncrnapred/index.html. All datasets used in this study can be obtained from the same website.

scholarly journals From Multiplex Serology to Serolomics—A Novel Approach to the Antibody Response against the SARS-CoV-2 Proteome

Viruses ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 749
Author(s):  
Julia Butt ◽  
Rajagopal Murugan ◽  
Theresa Hippchen ◽  
Sylvia Olberg ◽  
Monique van Straaten ◽  
...  
Keyword(s):  
Antibody Response ◽  
High Throughput ◽  
Large Population ◽  
High Sensitivity ◽  
Population Based ◽  
Antibody Responses ◽  
Hek293 Cells ◽  
Novel Approach ◽  
Assay Performance ◽  
Multiplex Serology

The emerging SARS-CoV-2 pandemic entails an urgent need for specific and sensitive high-throughput serological assays to assess SARS-CoV-2 epidemiology. We, therefore, aimed at developing a fluorescent-bead based SARS-CoV-2 multiplex serology assay for detection of antibody responses to the SARS-CoV-2 proteome. Proteins of the SARS-CoV-2 proteome and protein N of SARS-CoV-1 and common cold Coronaviruses (ccCoVs) were recombinantly expressed in E. coli or HEK293 cells. Assay performance was assessed in a COVID-19 case cohort (n = 48 hospitalized patients from Heidelberg) as well as n = 85 age- and sex-matched pre-pandemic controls from the ESTHER study. Assay validation included comparison with home-made immunofluorescence and commercial enzyme-linked immunosorbent (ELISA) assays. A sensitivity of 100% (95% CI: 86–100%) was achieved in COVID-19 patients 14 days post symptom onset with dual sero-positivity to SARS-CoV-2 N and the receptor-binding domain of the spike protein. The specificity obtained with this algorithm was 100% (95% CI: 96–100%). Antibody responses to ccCoVs N were abundantly high and did not correlate with those to SARS-CoV-2 N. Inclusion of additional SARS-CoV-2 proteins as well as separate assessment of immunoglobulin (Ig) classes M, A, and G allowed for explorative analyses regarding disease progression and course of antibody response. This newly developed SARS-CoV-2 multiplex serology assay achieved high sensitivity and specificity to determine SARS-CoV-2 sero-positivity. Its high throughput ability allows epidemiologic SARS-CoV-2 research in large population-based studies. Inclusion of additional pathogens into the panel as well as separate assessment of Ig isotypes will furthermore allow addressing research questions beyond SARS-CoV-2 sero-prevalence.

Fundamentals, On-Going Advances and Challenges of Electrochemical Carbon Dioxide Reduction

2021 ◽  
Author(s):  
Zongkui Kou ◽  
Xin Li ◽  
Tingting Wang ◽  
Yuanyuan Ma ◽  
Wenjie Zang ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Carbon Dioxide Reduction
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