scholarly journals An eco-friendly pathway to thermosensitive micellar nanoobjects via photoRAFT PISA: the full guide to poly(N-acryloylpyrrolidin)-block-polystyrene diblock copolymers

Soft Matter ◽  
2020 ◽  
Vol 16 (9) ◽  
pp. 2321-2331 ◽  
Author(s):  
Felix Lauterbach ◽  
Volker Abetz
Keyword(s):  
Biomedical Applications ◽  
Diblock Copolymers ◽  
Synthetic Polymers ◽  
Macromolecular Assemblies ◽  
Relevant Class

Spherical macromolecular assemblies, so-called latexes, consisting of polystyrene (PS) resemble a relevant class of synthetic polymers used for a plethora of applications ranging from coatings or lubricants to biomedical applications.

scholarly journals Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Gels ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 46
Author(s):  
Sihang Liu ◽  
Jingyi Tang ◽  
Fangqin Ji ◽  
Weifeng Lin ◽  
Shengfu Chen
Keyword(s):  
Immune System ◽  
Polyethylene Glycol ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Synthetic Polymers ◽  
Human Environment ◽  
The Past ◽  
Recent Advances ◽  
Nonspecific Protein Adsorption ◽  
Anionic Groups

Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.

SEM Characterisation of a Tricalcium Phosphate – Chitosan - PMMA Cement

2014 ◽  
Vol 614 ◽  
pp. 47-51
Author(s):  
Hella Mahjoub ◽  
Codruța Sarosi ◽  
Olga Orasan ◽  
Aniela Saplonţai-Pop
Keyword(s):  
Electron Microscopy ◽  
Methyl Methacrylate ◽  
Tricalcium Phosphate ◽  
Chemical Process ◽  
Biomedical Applications ◽  
Wide Spectrum ◽  
Synthetic Polymers ◽  
Intrinsic Activity ◽  
Pmma Cement ◽  
Scanning Electron

Synthetic Polymers, both organic and inorganic, are used in a wide variety of biomedical applications. The polymers can be biodegradable or nondegradable. Chitosan (CH), which is a naturally biodegradable, non-toxic biopolymer obtained by the deacetylation of chitin, has been demonstrated to have an intrinsic activity against a wide spectrum of bacteria, filamentous fungi and yeast. Several investigators have studied reinforced tricalcium phosphate (TCP), Chitosan, polymethylmethacrylate (PMMA)/methyl methacrylate (MMA) as potential cement. In fact addition of TCP with chitosan to the cement can improve biocompatibility and also enhance the mechanical properties of the cement because of its both biocompatibility and osteoconductivity properties. Crystalline phase and microstructure of the cement with hydroxyapatite - poly (methyl-methacrylate) were characterized by scanning electron microscopy (SEM; FEI Company), with the purpose to draw solid conclusions about the influence of the particles size, form and uniform mixing on the chemical process. We acquired PMMA sorted according to granulometric size.

scholarly journals A Critical Review on the Synthesis of Natural Sodium Alginate Based Composite Materials: An Innovative Biological Polymer for Biomedical Delivery Applications

Processes ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 137
Author(s):  
Awais Ahmad ◽  
N.M. Mubarak ◽  
Fakiha Tul Jannat ◽  
Tayyaba Ashfaq ◽  
Carlo Santulli ◽  
...  
Keyword(s):  
Sodium Alginate ◽  
Biomedical Applications ◽  
Alginic Acid ◽  
Synthetic Polymers ◽  
Water Soluble ◽  
Comprehensive Overview ◽  
New Techniques ◽  
Technical Issues ◽  
Scientific Technical ◽  
Immunogenic Properties

Sodium alginate (Na-Alg) is water-soluble, neutral, and linear polysaccharide. It is the derivative of alginic acid which comprises 1,4-β-d-mannuronic (M) and α-l-guluronic (G) acids and has the chemical formula (NaC6H7O6). It shows water-soluble, non-toxic, biocompatible, biodegradable, and non-immunogenic properties. It had been used for various biomedical applications, among which the most promising are drug delivery, gene delivery, wound dressing, and wound healing. For different biomedical applications, it is used in different forms with the help of new techniques. That is the reason it had been blended with different polymers. In this review article, we present a comprehensive overview of the combinations of sodium alginate with natural and synthetic polymers and their biomedical applications involving delivery systems. All the scientific/technical issues have been addressed, and we have highlighted the recent advancements.

Advances in drug delivery, gene delivery and therapeutic agents based on dendritic materials

2019 ◽  
Vol 11 (14) ◽  
pp. 1791-1810 ◽  
Author(s):  
Mario Contin ◽  
Cybele Garcia ◽  
Cecilia Dobrecky ◽  
Silvia Lucangioli ◽  
Norma D’Accorso
Keyword(s):  
Drug Delivery ◽  
Gene Delivery ◽  
Biomedical Applications ◽  
State Of The Art ◽  
Synthetic Polymers ◽  
Therapeutic Agents ◽  
Therapeutic Strategies ◽  
Common Point ◽  
Three Dimensions ◽  
Dendrimer Conjugates

Dendrimers are synthetic polymers that grow in three dimensions into well-defined structures. Their morphological appearance resembles a number of trees connected by a common point. Dendritic nanoparticles have been studied for a large number of pharmaceutical and biomedical applications including gene and drug delivery, clinical diagnosis and MRI. Despite the application of dendrimers, research is still in its childhood in comparison with liposomes and other nanomaterials. They are now playing a key role in several therapeutic strategies, with dendrimer-based products in clinical trials. The aim of this review is to describe the state-of-the-art of biomedical applications of dendrimers – and dendrimer conjugates – such as drug and gene delivery and antiviral activity.

Glycoproteins functionalized natural and synthetic polymers for prospective biomedical applications: A review

2017 ◽  
Vol 98 ◽  
pp. 748-776 ◽  
Author(s):  
Shazia Tabasum ◽  
Aqdas Noreen ◽  
Arooj Kanwal ◽  
Mohammad Zuber ◽  
Muhammad Naveed Anjum ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Synthetic Polymers ◽  
Natural And Synthetic

scholarly journals Effect of Dexamethasone on Thermoresponsive Behavior of Poly(2-Oxazoline) Diblock Copolymers

Polymers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1357
Author(s):  
Monika Majerčíková ◽  
Peter Nádaždy ◽  
Dušan Chorvát ◽  
Leonid Satrapinskyy ◽  
Helena Valentová ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Diblock Copolymers ◽  
Polarized Light ◽  
Drug Carriers ◽  
Thermoresponsive Polymers ◽  
X Ray Scattering ◽  
Small Series ◽  
Cloud Point Temperature ◽  
Crystalline Nature ◽  
Chain Lengths

Thermoresponsive polymers play an important role in designing drug delivery systems for biomedical applications. In this contribution, the effect of encapsulated hydrophobic drug dexamethasone on thermoresponsive behavior of diblock copolymers was studied. A small series of diblock copoly(2-oxazoline)s was prepared by combining thermoresponsive 2-n-propyl-2-oxazoline (nPrOx) and hydrophilic 2-methyl-2-oxazoline (MeOx) in two ratios and two polymer chain lengths. The addition of dexamethasone affected the thermoresponsive behavior of one of the copolymers, nPrOx20-MeOx180, in the aqueous medium by shifting the cloud point temperature to lower values. In addition, the formation of microparticles containing dexamethasone was observed during the heating of the samples. The morphology and number of microparticles were affected by the structure and concentration of copolymer, the drug concentration, and the temperature. The crystalline nature of formed microparticles was confirmed by polarized light microscopy, confocal Raman microscopy, and wide-angle X-ray scattering. The results demonstrate the importance of studying drug/polymer interactions for the future development of thermoresponsive drug carriers.

scholarly journals Interpenetrating polymeric hydrogels as favorable materials for hygienic applications

2020 ◽  
Vol 10 (2) ◽  
pp. 5011-5020
Keyword(s):  
Biomedical Applications ◽  
Three Dimensional ◽  
Synthetic Polymers ◽  
Poly Vinyl Alcohol ◽  
Ambient Conditions ◽  
Natural Polymers ◽  
Dimensional Network ◽  
Swelling Capacity ◽  
Polymeric Chains ◽  
Poly Ethylene

Polymers can crosslink to produce intermingled materials with three-dimensional network structure known as interpenetrating polymeric network (IPN). They comprise elastic crosslinked polymeric chains. The chains of the hydrogels are either physically or chemically entangled together. Interpenetrating hydrogels can be tailored to provide enhanced materials. They can be classified according to methods of their synthesis as simultaneous or sequential IPNs and the structure to be homo or semi IPNs. The preparation factors play a role in controlling the properties of the produced IPNs. Moreover, the ambient conditions such as pH, temperature as well as the ionic strength may affect the performance of these hydrogels. The swelling capacity is an important feature that allows the prepared hydrogel to perform the required application. Some disadvantages may arise such as the low mechanical properties that are suggested to be overcome. IPNs can be used in various applications that serve the human requirements like drug delivery, tissue engineering, medical and packaging applications. Hydrogels present biocompatibility and nontoxicity when used in biomedical applications. Interpenetrating hydrogels can be prepared from natural or synthetic polymers. Polysaccharides as natural polymers can be used to produce efficient interpenetrating hydrogels. Polyacrylates, poly(ethylene glycol) and poly(vinyl alcohol) are designated as promising synthetic polymers capable of forming interpenetrating hydrogels.

scholarly journals New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1539 ◽  
Author(s):  
Cornelia Vasile ◽  
Daniela Pamfil ◽  
Elena Stoleru ◽  
Mihaela Baican
Keyword(s):  
Biomedical Applications ◽  
Chemical Properties ◽  
Synthetic Polymers ◽  
Point Of View ◽  
Natural Polymers ◽  
New Developments ◽  
Organic Hybrid ◽  
Hybrid Hydrogels ◽  
Physico Chemical ◽  
Polymeric Hydrogels

New trends in biomedical applications of the hybrid polymeric hydrogels, obtained by combining natural polymers with synthetic ones, have been reviewed. Homopolysaccharides, heteropolysaccharides, as well as polypeptides, proteins and nucleic acids, are presented from the point of view of their ability to form hydrogels with synthetic polymers, the preparation procedures for polymeric organic hybrid hydrogels, general physico-chemical properties and main biomedical applications (i.e., tissue engineering, wound dressing, drug delivery, etc.).

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