scholarly journals Sulfatase-cleavable linkers for antibody-drug conjugates

2020 ◽  
Vol 11 (9) ◽  
pp. 2375-2380 ◽  
Author(s):  
Jonathan D. Bargh ◽  
Stephen J. Walsh ◽  
Albert Isidro-Llobet ◽  
Soleilmane Omarjee ◽  
Jason S. Carroll ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

Arylsulfate-containing linkers are cleaved by lysosomal sulfatases to release payloads from ADCs at targeted cancer cells.

scholarly journals A New Triglycyl Peptide Linker for Antibody–Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells

2016 ◽  
Vol 15 (6) ◽  
pp. 1311-1320 ◽  
Author(s):  
Rajeeva Singh ◽  
Yulius Y. Setiady ◽  
Jose Ponte ◽  
Yelena V. Kovtun ◽  
Katharine C. Lai ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Targeted Killing ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

scholarly journals Computational Construction of Antibody–Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker

2014 ◽  
Vol 13 ◽  
pp. CIN.S19222 ◽  
Author(s):  
Arianna Filntisi ◽  
Dimitrios Vlachakis ◽  
George K. Matsopoulos ◽  
Sophia Kossida
Keyword(s):  
Targeted Therapy ◽  
Side Effects ◽  
Cancer Cells ◽  
Data Bank ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Conjugation ◽  
Cytotoxic Substance ◽  
Protein Data Bank Format ◽  
Antibody Drug

Antibody-drug conjugates (ADCs) constitute a category of anticancer targeted therapy that has gathered great interest during the last few years because of their potential to kill cancer cells while causing significantly fewer side effects than traditional chemotherapy. In this paper, a process of computational construction of ADCs is described, using the surface lysines of an antibody and a non-covalent linker molecule, as well as a cytotoxic substance, as files in Protein Data Bank format. Also, aspects related to the function, properties, and development of ADCs are discussed.

scholarly journals Internalization of CD239 highly expressed in breast cancer cells: a potential antigen for antibody-drug conjugates

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Yamato Kikkawa ◽  
Yurie Enomoto-Okawa ◽  
Aiko Fujiyama ◽  
Takeshi Fukuhara ◽  
Nozomi Harashima ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug
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