scholarly journals Supramolecular chirality transformation driven by monodentate ligand binding to a coordinatively unsaturated self-assembly based on C3-symmetric ligands

2019 ◽  
Vol 10 (15) ◽  
pp. 4236-4245 ◽  
Author(s):  
Yuki Imai ◽  
Junpei Yuasa
Keyword(s):  
Ligand Binding ◽  
Self Assembly ◽  
Rational Design ◽  
External Stimulus ◽  
Monodentate Ligand ◽  
Supramolecular Chirality ◽  
Dynamic Coordination ◽  
Different Shapes ◽  
Symmetric Ligands

A supramolecular chirality transition driven by monodentate ligand binding, the present strategy shows promise for the rational design of dynamic coordination chirality capable of alternating between chiral objects of different shapes driven by a specific external stimulus.

Hierarchical self-assembly of an azobenzene dyad with inverted amide connection into toroidal and tubular nanostructures

2020 ◽  
Vol 18 (21) ◽  
pp. 3996-3999
Author(s):  
Takuho Saito ◽  
Shiki Yagai
Keyword(s):  
Thermal Stability ◽  
Self Assembly ◽  
Supramolecular Chirality ◽  
Thermal Stability Of

Inversion of the amide connectivity of an azobenzene dyad, which self-assembles into chiral toroids and nanotubes, improves the thermal stability of the assemblies, however it negatively affects supramolecular chirality.

Examining the structure of the mature amyloid fibril

2002 ◽  
Vol 30 (4) ◽  
pp. 521-525 ◽  
Author(s):  
O. S. Makin ◽  
L. C. Serpell
Keyword(s):  
Self Assembly ◽  
Rational Design ◽  
Amyloid Fibrils ◽  
Structural Information ◽  
X Ray ◽  
X Ray Crystallography ◽  
Cryo Electron Microscopy ◽  
Fibre Diffraction ◽  
Complementary Techniques ◽  
Mature Fibril

The pathogenesis of the group of diseases known collectively as the amyloidoses is characterized by the deposition of insoluble amyloid fibrils. These are straight, unbranching structures about 70–120 å (1 å = 0.1 nm) in diameter and of indeterminate length formed by the self-assembly of a diverse group of normally soluble proteins. Knowledge of the structure of these fibrils is necessary for the understanding of their abnormal assembly and deposition, possibly leading to the rational design of therapeutic agents for their prevention or disaggregation. Structural elucidation is impeded by fibril insolubility and inability to crystallize, thus preventing the use of X-ray crystallography and solution NMR. CD, Fourier-transform infrared spectroscopy and light scattering have been used in the study of the mechanism of fibril formation. This review concentrates on the structural information about the final, mature fibril and in particular the complementary techniques of cryo-electron microscopy, solid-state NMR and X-ray fibre diffraction.

scholarly journals Ag–Au Core–Shell Triangular Nanoprisms for Improving p-g-C3N4 Photocatalytic Hydrogen Production

Nanomaterials ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3347
Author(s):  
Yali Guo ◽  
Anzhou Xu ◽  
Juan Hou ◽  
Qingcui Liu ◽  
Hailong Li ◽  
...  
Keyword(s):  
Hydrogen Production ◽  
Self Assembly ◽  
Rational Design ◽  
Photogenerated Electron ◽  
Core Shell ◽  
Co Catalyst ◽  
Replacement Method ◽  
Assembly Method ◽  
Free Replacement ◽  
Electron Holes

Ag–Au core–shell triangular nanoprisms (Ag@Au TNPs) have aroused extensive research interest in the field of hydrogen evolution reaction (HER) due to their strong plasmon effect and stability. Here, Ag@Au TNPs were fabricated by the galvanic-free replacement method. Then, we loaded them on protonated g-C3N4 nanoprisms (P–CN) by the electrostatic self-assembly method as an efficient plasmonic photocatalyst for HER. The hydrogen production rate of Ag@Au TNPs/P–CN (4.52 mmol/g/h) is 4.1 times higher than that of P–CN (1.11 mmol/g/h) under simulated sunlight irradiation, making it the most competitive material for water splitting. The formed Schottky junction helps to trap the hot electrons generated from Ag@Au TNPs, and the well-preserved tips of the Ag@Au TNPs can effectively generate an electromagnetic field to inhibit the photogenerated electron–holes pairs recombination. This study suggests that the rational design of Ag@Au TNPs by the galvanic-free replacement method is an effective co-catalyst for HER and boosting the additional combination of plasmonic metals and catalyst metals for the enhancement to HER.

scholarly journals Engineering DNA recognition and allosteric response properties of TetR family proteins by using a module-swapping strategy

2019 ◽  
Vol 47 (16) ◽  
pp. 8913-8925 ◽  
Author(s):  
Rey P Dimas ◽  
Benjamin R Jordan ◽  
Xian-Li Jiang ◽  
Catherine Martini ◽  
Joseph S Glavy ◽  
...  
Keyword(s):  
Dna Binding ◽  
Ligand Binding ◽  
Cellular Response ◽  
Rational Design ◽  
Dna Recognition ◽  
Response Properties ◽  
Effective Components ◽  
Uniprot Accession ◽  
Engineering Strategy ◽  
Molecular Signal

Abstract The development of synthetic biological systems requires modular biomolecular components to flexibly alter response pathways. In previous studies, we have established a module-swapping design principle to engineer allosteric response and DNA recognition properties among regulators in the LacI family, in which the engineered regulators served as effective components for implementing new cellular behavior. Here we introduced this protein engineering strategy to two regulators in the TetR family: TetR (UniProt Accession ID: P04483) and MphR (Q9EVJ6). The TetR DNA-binding module and the MphR ligand-binding module were used to create the TetR-MphR. This resulting hybrid regulator possesses DNA-binding properties of TetR and ligand response properties of MphR, which is able to control gene expression in response to a molecular signal in cells. Furthermore, we studied molecular interactions between the TetR DNA-binding module and MphR ligand-binding module by using mutant analysis. Together, we demonstrated that TetR family regulators contain discrete and functional modules that can be used to build biological components with novel properties. This work highlights the utility of rational design as a means of creating modular parts for cell engineering and introduces new possibilities in rewiring cellular response pathways.

scholarly journals Rational Design of Helical Nanotubes from Self-assembly of Coiled-coil Lock Washers

2013 ◽  
Vol 19 (S2) ◽  
pp. 342-343
Author(s):  
C. Xu ◽  
E.R. Wright ◽  
A. Mehta ◽  
L.C. Ser-pell ◽  
X. Zuo ◽  
...  
Keyword(s):  
Self Assembly ◽  
Rational Design ◽  
Coiled Coil

Extended abstract of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.

Aggregation behavior of tetraphenylporphyrin in aqueous surfactant solutions: Chiral premicellar J-aggregate formation

2015 ◽  
Vol 19 (07) ◽  
pp. 845-851 ◽  
Author(s):  
Margaret A. Gradova ◽  
Vladimir V. Artemov ◽  
Anton V. Lobanov
Keyword(s):  
Anionic Surfactant ◽  
Self Assembly ◽  
Photophysical Properties ◽  
Direct Synthesis ◽  
Aggregate Formation ◽  
Experimental Conditions ◽  
Aggregation State ◽  
Supramolecular Chirality ◽  
Surfactant Solutions ◽  
Surfactant Interactions

Porphyrin-surfactant interactions in aqueous solutions are known to result in the selfassembly of various supramolecular structures, including pigment-surfactant complexes, J- and H-aggregates, and solubilized dye species. Detailed studies on the mechanisms of the intermolecular interactions governing the above self-assembly processes allow to predict the aggregation state and hence, the photophysical properties of the dye-surfactant assemblies in order to perform a direct synthesis of the desired porphyrin-based nanostructures at the appropriate experimental conditions. This paper describes a novel example of the surfactant-induced J-aggregate formation from the diprotonated hydrophobic tetraphenylporphyrin species in submicellar aqueous anionic surfactant solutions. The above assemblies are characterized by a rod-like morphology and possess supramolecular chirality according to the CD measurements.

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