scholarly journals Upconversion-mediated ZnFe2O4 nanoplatform for NIR-enhanced chemodynamic and photodynamic therapy

2019 ◽  
Vol 10 (15) ◽  
pp. 4259-4271 ◽  
Author(s):  
Shuming Dong ◽  
Jiating Xu ◽  
Tao Jia ◽  
Mengshu Xu ◽  
Chongna Zhong ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photocatalytic Activity ◽  
Photodynamic Therapy ◽  
Uv Light ◽  
Reactive Oxygen ◽  
High Photocatalytic Activity ◽  
Oxygen Species

ZnFe2O4, a semiconductor catalyst with high photocatalytic activity, is ultrasensitive to ultraviolet (UV) light and tumor H2O2 for producing reactive oxygen species (ROS).

Particularities of photocatalysis and formation of reactive oxygen species on insulators and semiconductors: cases of SiO2, TiO2 and their composite SiO2–TiO2

2018 ◽  
Vol 8 (21) ◽  
pp. 5657-5668 ◽  
Author(s):  
Crina Anastasescu ◽  
Catalin Negrila ◽  
Daniel G. Angelescu ◽  
Irina Atkinson ◽  
Mihai Anastasescu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photocatalytic Activity ◽  
Reactive Oxygen ◽  
Oxygen Species

Highly defected tubular SiO2 outperforms the photocatalytic activity of TiO2-P25 and the SiO2–TiO2 composite.

scholarly journals Rare-Earth-Doped Calcium Carbonate Exposed to X-ray Irradiation to Induce Reactive Oxygen Species for Tumor Treatment

2019 ◽  
Vol 20 (5) ◽  
pp. 1148 ◽  
Author(s):  
Chun-Chen Yang ◽  
Wei-Yun Wang ◽  
Feng-Huei Lin ◽  
Chun-Han Hou
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Growth ◽  
Light Source ◽  
Reactive Oxygen ◽  
Blood Analysis ◽  
Oxygen Species ◽  
Tumor Treatment ◽  
X Ray

Conventional photodynamic therapy (PDT) is limited by its penetration depth due to the photosensitizer and light source. In this study, we developed X-ray induced photodynamic therapy that applied X-ray as the light source to activate Ce-doped CaCO3 (CaCO3:Ce) to generate an intracellular reactive oxygen species (ROS) for killing cancer cells. The A549 cell line was used as the in vitro and in vivo model to evaluate the efficacy of X-ray-induced CaCO3:Ce. The cell viability significantly decreased and cell cytotoxicity obviously increased with CaCO3:Ce exposure under X-ray irradiation, which is less harmful than radiotherapy in tumor treatment. CaCO3:Ce produced significant ROS under X-ray irradiation and promoted A549 cancer cell death. CaCO3:Ce can enhance the efficacy of X-ray induced PDT, and tumor growth was inhibited in vivo. The blood analysis and hematoxylin and eosin stain (H&E) stain fully supported the safety of the treatment. The mechanisms underlying ROS and CO2 generation by CaCO3:Ce activated by X-ray irradiation to induce cell toxicity, thereby inhibiting tumor growth, is discussed. These findings and advances are of great importance in providing a novel therapeutic approach as an alternative tumor treatment.

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