scholarly journals Secondary amines as coupling partners in direct catalytic asymmetric reductive amination

2019 ◽  
Vol 10 (16) ◽  
pp. 4509-4514 ◽  
Author(s):  
Zitong Wu ◽  
Shaozhi Du ◽  
Guorui Gao ◽  
Wenkun Yang ◽  
Xiongyu Yang ◽  
...  
Keyword(s):  
Reductive Amination ◽  
Secondary Amines ◽  
Chiral Amines ◽  
Efficient Tool ◽  
One Step ◽  
Catalytic Asymmetric

Direct asymmetric reductive amination utilizing secondary amines as an efficient tool for one-step construction of tertiary chiral amines.

One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive amination applying imine reductases

2017 ◽  
Vol 19 (2) ◽  
pp. 385-389 ◽  
Author(s):  
P. Matzel ◽  
M. Gand ◽  
M. Höhne
Keyword(s):  
Asymmetric Synthesis ◽  
Reductive Amination ◽  
Secondary Amines ◽  
One Step

Imine reductases (IREDs) show great potential as catalysts for reductive amination of ketones to produce chiral secondary amines.

Cobalt encapsulated in N‑doped graphene sheet for one-pot reductive amination to synthesize secondary amines

2021 ◽  
Vol 505 ◽  
pp. 111504
Author(s):  
Lin Liu ◽  
Wenxiu Li ◽  
Ran Qi ◽  
Qingqing Zhu ◽  
Jing Li ◽  
...  
Keyword(s):  
Graphene Sheet ◽  
Reductive Amination ◽  
Secondary Amines ◽  
One Pot ◽  
Doped Graphene

scholarly journals Facile Synthesis of COF-Supported Reduced Pd-Based Catalyst for One-Pot Reductive Amination of Aldehydes

Catalysts ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 287
Author(s):  
Jianguo Liu ◽  
Mingyue Zhang ◽  
Longlong Ma
Keyword(s):  
Heterogeneous Catalysts ◽  
Reductive Amination ◽  
Secondary Amines ◽  
Metallic State ◽  
One Pot ◽  
Effective Synthesis ◽  
Pharmaceutical Industries ◽  
The One ◽  
Heterocyclic Aldehydes ◽  
Supported Pd

Dibenzylamine motifs are an important class of crucial organic compounds and are widely used in fine chemical and pharmaceutical industries. The development of the efficient, economical, and environmentally friendly synthesis of amines using transition metal-based heterogeneous catalysts remains both desirable and challenging. Herein, we prepared the covalent organic framework (COF)-supported heterogeneous reduced COF-supported Pd-based catalyst and used it for the one-pot reductive amination of aldehydes. There are both Pd metallic state and oxidated Pdσ+ in the catalysts. Furthermore, in the presence of the reduced COF-supported Pd-based catalyst, many aromatic, aliphatic, and heterocyclic aldehydes with various functional groups substituted were converted to their corresponding amines products in good to excellent selectivity (up to 91%) under mild reaction conditions (70 °C, 2 h, NH3, 20 bar H2). This work expands the covalent organic frameworks for the material family and its support catalyst, opening up new catalytic applications in the economical, practical, and effective synthesis of secondary amines.

Direct reductive amination of aldehydes using lithium-arene(cat.) as reducing system. A simple one-pot procedure for the synthesis of secondary amines

2012 ◽  
Vol 53 (25) ◽  
pp. 3156-3160 ◽  
Author(s):  
Fabiana Nador ◽  
Yanina Moglie ◽  
Andrés Ciolino ◽  
Adriana Pierini ◽  
Viviana Dorn ◽  
...  
Keyword(s):  
Reductive Amination ◽  
Secondary Amines ◽  
One Pot ◽  
System A

scholarly journals Direct Catalytic Asymmetric Mannich-Type Reaction of an α-CF3 Amide to Isatin Imines

Synlett ◽  
2018 ◽  
Vol 30 (04) ◽  
pp. 488-492 ◽  
Author(s):  
Jin-Sheng Yu ◽  
Hidetoshi Noda ◽  
Naoya Kumagai ◽  
Masakatsu Shibasaki
Keyword(s):  
Lewis Acid ◽  
Tertiary Amine ◽  
Chiral Center ◽  
Chiral Catalyst ◽  
Type Reaction ◽  
One Step ◽  
Catalytic Asymmetric ◽  
Chiral Bisphosphine Ligand

An α-CF3 amide underwent direct asymmetric Mannich-type reaction to isatin imines in the presence of a chiral catalyst comprising a soft Lewis acid Cu(I), a chiral bisphosphine ligand, and Barton’s base. The Mannich adduct was converted in one step into a unique tricycle bearing a trifluoromethylated chiral center and an α-tertiary amine moiety.

ChemInform Abstract: Catalytic Asymmetric Reductive Amination of α-Branched Ketones.

ChemInform ◽  
2010 ◽  
Vol 41 (44) ◽  
pp. no-no
Author(s):  
Vijay N. Wakchaure ◽  
Jian Zhou ◽  
Sebastian Hoffmann ◽  
Benjamin List
Keyword(s):  
Reductive Amination ◽  
Catalytic Asymmetric

scholarly journals A Single-Step Synthesis of Azetidine-3-Amines

2020 ◽  
Author(s):  
Brian J Wang ◽  
Matthew Duncton
Keyword(s):  
Functional Groups ◽  
Late Stage ◽  
Single Step ◽  
Secondary Amines ◽  
High Yield ◽  
Primary Amines ◽  
Privileged Structure ◽  
One Step ◽  
Alternative Procedures ◽  
Approved Drugs

<div> <p>The azetidine group is frequently encountered within contemporary medicinal chemistry where it is viewed as a privileged structure. However, the introduction of an azetidine can be synthetically challenging. Herein, a straight-forward one step synthesis of azetidine-3-amines, starting from a bench stable, commercial material is presented. The reaction tolerates functional groups commonly encountered in biological-, medicinal- and agro-chemistry, and proceeds in moderate-to-high yield with secondary amines, and moderate-to-low yield with primary amines. The methodology compares favorably to recent alternative procedures and can be utilized in “any-stage” functionalization, including late-stage azetidinylation of approved drugs and other compounds with pharmacological activity.</p> </div>

One-Step Homologation for the Catalytic Asymmetric Synthesis of Deoxypropionates

2016 ◽  
Vol 23 (1) ◽  
pp. 149-156 ◽  
Author(s):  
Shiqing Xu ◽  
Haijun Li ◽  
Masato Komiyama ◽  
Akimichi Oda ◽  
Ei-ichi Negishi
Keyword(s):  
Asymmetric Synthesis ◽  
Catalytic Asymmetric Synthesis ◽  
One Step ◽  
Catalytic Asymmetric
Sign in / Sign up

Export Citation Format

Share Document