Flow-controlled synthesis of gold nanoparticles in a biphasic system with inline liquid–liquid separation

2020 ◽  
Vol 5 (2) ◽  
pp. 356-366 ◽  
Author(s):  
Edith Chow ◽  
Burkhard Raguse ◽  
Enrico Della Gaspera ◽  
Steven J. Barrow ◽  
Jungmi Hong ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Flow Reactor ◽  
Reactor System ◽  
Biphasic System ◽  
Controlled Synthesis ◽  
Liquid Separation

4-Dimethylaminopyridine-stabilised gold nanoparticles are synthesised in a biphasic flow reactor system using organic/aqueous membrane separators and gas-permeable tubing.

scholarly journals Atmospheric-Pressure Pulsed Discharge Plasma in a Slug Flow Reactor System for the Synthesis of Gold Nanoparticles

ACS Omega ◽  
2020 ◽  
Vol 5 (28) ◽  
pp. 17679-17685
Author(s):  
Motoki Yamada ◽  
Wahyudiono ◽  
Siti Machmudah ◽  
Hideki Kanda ◽  
Yaping Zhao ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Atmospheric Pressure ◽  
Slug Flow ◽  
Discharge Plasma ◽  
Flow Reactor ◽  
Reactor System ◽  
Pulsed Discharge ◽  
Pulsed Discharge Plasma

scholarly journals Continuous citrate‐capped gold nanoparticle synthesis in a two‐phase flow reactor

2021 ◽  
Author(s):  
Spyridon Damilos ◽  
Ioannis Alissandratos ◽  
Luca Panariello ◽  
Anand N. P. Radhakrishnan ◽  
Enhong Cao ◽  
...  
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Residence Time ◽  
Flow Reactor ◽  
Phase Flow ◽  
Continuous Manufacturing ◽  
Two Phase ◽  
Process Yield ◽  
Au Nps ◽  
Manufacturing Platform

AbstractA continuous manufacturing platform was developed for the synthesis of aqueous colloidal 10–20 nm gold nanoparticles (Au NPs) in a flow reactor using chloroauric acid, sodium citrate and citric acid at 95 oC and 2.3 bar(a) pressure. The use of a two-phase flow system – using heptane as the continuous phase – prevented fouling on the reactor walls, while improving the residence time distribution. Continuous syntheses for up to 2 h demonstrated its potential application for continuous manufacturing, while live quality control was established using online UV-Vis photospectrometry that monitored the particle size and process yield. The synthesis was stable and reproducible over time for gold precursor concentration above 0.23 mM (after mixing), resulting in average particle size between 12 and 15 nm. A hydrophobic membrane separator provided successful separation of the aqueous and organic phases and collection of colloidal Au NPs in flow. Process yield increased at higher inlet flow rates (from 70 % to almost 100 %), due to lower residence time of the colloidal solution in the separator resulting in less fouling in the PTFE membrane. This study addresses the challenges for the translation of the synthesis from batch to flow and provides tools for the development of a continuous manufacturing platform for gold nanoparticles.Graphical abstract

scholarly journals Continuous Flow Controlled Synthesis of Gold Nanoparticles Using Pulsed Mixing Microfluidic System

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Guojun Liu ◽  
Xuhao Yang ◽  
Yan Li ◽  
Zhigang Yang ◽  
Wen Hong ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Flow Rate ◽  
Research Work ◽  
Microfluidic System ◽  
Noble Metal Nanoparticles ◽  
Controlled Synthesis ◽  
Entrance Angle ◽  
Section Size ◽  
Pulsed Mixing ◽  
Entrance Flow

To prepare the gold nanoparticles (AuNPs) with uniform sizes, fine morphology, and good monodispersity, a pulsed mixing microfluidic system based on PZT actuation was presented. The system includes PZT micropump and Y type micromixer. By adjusting voltage (entrance flow rate), pulsed frequency, phase, and other parameters, a variety of mixing modes can be achieved, so as to realize the controllable synthesis of nanoparticles in a certain range. By numerical simulation and analysis, the channel section size, entrance angle, and pulse frequency were optimized. Based on the optimized structure and working parameters, the test prototype has been manufactured in lab, and the related synthesis tests of AuNPs were carried out. The test results indicate that AuNPs with uniform morphology and good monodispersity can be synthesized using the system with the section size (0.4 mm × 0.4 mm), the entrance channel angle (60°) under condition of the pulsed frequency (300 Hz), and the entrance flow rate (4 mL/min). The average diameter and its standard deviation of AuNPs synthesized were 21.6 nm, 4.83 nm, respectively. The research work above can be applied to the fields such as the controlled synthesis of noble metal nanoparticles, biomedicine, and microchemical system.

Size-Controlled Synthesis of Gold Nanoparticles via High-Temperature Reduction

Langmuir ◽  
2004 ◽  
Vol 20 (8) ◽  
pp. 3021-3023 ◽  
Author(s):  
David A. Fleming ◽  
Mary Elizabeth Williams
Keyword(s):  
Gold Nanoparticles ◽  
High Temperature ◽  
Controlled Synthesis ◽  
Temperature Reduction ◽  
Size Controlled
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