Catalysis in medicinal chemistry

2019 ◽  
Vol 4 (9) ◽  
pp. 1530-1535 ◽  
Author(s):  
Spencer D. Dreher
Keyword(s):  
Transition Metal ◽  
Medicinal Chemistry ◽  
Transition Metal Catalysis ◽  
Catalytic Reactions ◽  
Photoredox Catalysis ◽  
Metal Catalysis ◽  
Chemical Matter

The advent of transition-metal catalysis (and likewise, bio-catalysis, photoredox-catalysis and organo-catalysis, etc.) promises to greatly increase access to diverse chemical matter in medicinal chemistry, but new catalytic reactions often fail to deliver product in applied synthesis.

Merging photoredox catalysis with transition metal catalysis: Direct C4-H amination of 8-hydroxyquinoline derivatives

Tetrahedron ◽  
2019 ◽  
Vol 75 (29) ◽  
pp. 3904-3910
Author(s):  
Yueyue Ma ◽  
Yaqi Shi ◽  
Fan Yang ◽  
Yusheng Wu ◽  
Yangjie Wu
Keyword(s):  
Transition Metal ◽  
Transition Metal Catalysis ◽  
Photoredox Catalysis ◽  
Metal Catalysis

scholarly journals Dialkylation of Indoles with Trichloroacetimidates to Access 3,3-Disubstituted Indolenines

Molecules ◽  
2019 ◽  
Vol 24 (22) ◽  
pp. 4143
Author(s):  
Tamie Suzuki ◽  
Nilamber A. Mate ◽  
Arijit A. Adhikari ◽  
John D. Chisholm
Keyword(s):  
Natural Products ◽  
Transition Metal ◽  
Small Molecule ◽  
Lewis Acid ◽  
Medicinal Chemistry ◽  
Transition Metal Catalysis ◽  
Metal Catalysis ◽  
Rapid Access ◽  
Privileged Scaffolds

2-Substituted indoles may be directly transformed to 3,3-dialkyl indolenines with trichloroacetimidate electrophiles and the Lewis acid TMSOTf. These reactions provide rapid access to complex indolenines which are present in a variety of complex natural products and medicinally relevant small molecule structures. This method provides an alternative to the use of transition metal catalysis. The indolenines are readily transformed into spiroindoline systems which are privileged scaffolds in medicinal chemistry.

scholarly journals Merging Transition-Metal Catalysis with Photoredox Catalysis: An Environmentally Friendly Strategy for C–H Functionalization

Synthesis ◽  
2018 ◽  
Vol 50 (17) ◽  
pp. e2-e3
Author(s):  
Wen-Jun Zhou ◽  
Da-Gang Yu ◽  
Yi-Han Zhang ◽  
Yong-Yuan Gui ◽  
Liang Sun
Keyword(s):  
Transition Metal ◽  
Environmentally Friendly ◽  
Transition Metal Catalysis ◽  
Photoredox Catalysis ◽  
Metal Catalysis

Merging Transition-Metal Catalysis with Photoredox Catalysis: An Environmentally Friendly Strategy for C–H Functionalization

Synthesis ◽  
2018 ◽  
Vol 50 (17) ◽  
pp. 3359-3378 ◽  
Author(s):  
Wen-Jun Zhou ◽  
Da-Gang Yu ◽  
Yi-Han Zhang ◽  
Yong-Yuan Gui ◽  
Liang Sun
Keyword(s):  
Transition Metal ◽  
High Selectivity ◽  
Rapid Development ◽  
Palladium Catalysis ◽  
Transition Metal Catalysis ◽  
Nickel Catalysis ◽  
Photoredox Catalysis ◽  
Reaction Conditions ◽  
Metal Catalysis ◽  
Metal Catalyzed

Transition-metal-catalyzed C–H functionalization is already a useful tool in organic synthesis, whilst the rapid development of photoredox catalysis provides new pathways for C–H functionalization with high selectivity and efficiency under mild reaction conditions. In this review, recent advances in C–H functionalization through merging transition­-metal catalysis with photoredox catalysis are discussed.1 Introduction2 Merging Nickel Catalysis with Photoredox Catalysis3 Merging Palladium Catalysis with Photoredox Catalysis4 Merging Cobalt Catalysis with Photoredox Catalysis5 Merging Photoredox Catalysis with Other Transition-Metal Catalysis­6 Conclusions

C-H Bond Functionalization by Dual Catalysis: Merging of High-Valent Cobalt and Photoredox Catalysis

2021 ◽  
Author(s):  
Priyanka Chakraborty ◽  
Rajib Mandal ◽  
Soumen Paira ◽  
Basker Sundararaju
Keyword(s):  
Transition Metal ◽  
Transition Metal Catalysis ◽  
Low Energy ◽  
The Other ◽  
Photoredox Catalysis ◽  
Metal Catalysis ◽  
Bond Functionalization ◽  
Dual Catalysis ◽  
High Valent ◽  
Energy Pathways

The merger of transition metal catalysis and photocatalysis has emerged as a versatile platform which opened the gateway to diverse low energy pathways for several synthetic transformations. On the other...

Merging photoredox catalysis with transition metal catalysis: site-selective C4 or C5-H phosphonation of 8-aminoquinoline amides

2017 ◽  
Vol 4 (10) ◽  
pp. 1981-1986 ◽  
Author(s):  
Huijie Qiao ◽  
Suyan Sun ◽  
Yue Zhang ◽  
Hongmei Zhu ◽  
Xiaomeng Yu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Transition Metal Catalysis ◽  
Photoredox Catalysis ◽  
Metal Catalysis ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Site Selective

A simple and efficient protocol for the transition metal-catalyzed site-selective C–H phosphonation of 8-aminoquinoline at the C4 or C5 positions via a photoredox process was developed.

Cooperative photoredox catalysis

2016 ◽  
Vol 45 (11) ◽  
pp. 3026-3038 ◽  
Author(s):  
Xianjun Lang ◽  
Jincai Zhao ◽  
Xiaodong Chen
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Transition Metal Catalysis ◽  
Photoredox Catalysis ◽  
Organic Transformations ◽  
Metal Catalysis

Cooperative photoredox catalysis bridges visible-light photoredox catalysis with other types of catalysis like transition-metal catalysis, biocatalysis or electrocatalysis for establishing demanding organic transformations.

Carbon‐Sulfur Bond Constructions: From Transition‐Metal Catalysis to Sustainable Catalysis

2021 ◽  
Author(s):  
Pratheepkumar Annamalai ◽  
Ke‐Chien Liu ◽  
Satpal Singh Badsara ◽  
Chin‐Fa Lee
Keyword(s):  
Transition Metal ◽  
Transition Metal Catalysis ◽  
Metal Catalysis ◽  
Sulfur Bond

An electrochemical perspective on the roles of ligands in the merger of transition-metal catalysis and electrochemistry

2020 ◽  
Author(s):  
Ke-Yin Ye ◽  
Jun-Song Zhong ◽  
Yi Yu ◽  
Zhaojiang Shi
Keyword(s):  
Transition Metal ◽  
Organic Synthesis ◽  
Transition Metal Catalysis ◽  
Metal Catalysis

The merger of transition-metal catalysis and electrochemistry has been emerging as a very versatile and robust synthetic tool in organic synthesis. Like in their non-electrochemical variants, ligands also play crucial...

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