scholarly journals Newly synthesized 3-(4-chloro-phenyl)-3-hydroxy-2,2-dimethyl-propionic acid methyl ester derivatives selectively inhibit the proliferation of colon cancer cells

RSC Advances ◽  
2020 ◽  
Vol 10 (15) ◽  
pp. 8825-8841
Author(s):  
Samir M. El Rayes ◽  
Ahmed Aboelmagd ◽  
Mohamed S. Gomaa ◽  
Walid Fathalla ◽  
Ibrahim A. I. Ali ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Methyl Ester ◽  
Cancer Cells ◽  
Propionic Acid ◽  
Acid Methyl Ester ◽  
Colon Cancer Cells ◽  
Structure Modification ◽  
Acid Methyl

A series of 24 compounds were synthesized based on structure modification of the model methyl-3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropanoate as potent HDACIs.

scholarly journals Triterpenoids and Alkaloids from the Roots of Peganum Nigellastrum

2008 ◽  
Vol 3 (2) ◽  
pp. 1934578X0800300
Author(s):  
Zhongze Ma ◽  
Yoshio Hano ◽  
Feng Qiu ◽  
Gang Shao ◽  
Yingjie Chen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Methyl Ester ◽  
Cancer Cells ◽  
Acid Methyl Ester ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Pentacyclic Triterpenoids ◽  
Acid Methyl ◽  
Androgen Independent ◽  
Chemical Evidence

Four lupane-type triterpenoids (1–4) and seven alkaloids (5–11) were isolated from the roots of Peganum nigellastrum. On the basis of spectroscopic and chemical evidence, the structures of the compounds were elucidated as 3α-hydroxy-27- trans-caffeoyloxylup-20(29)-en-28-oic acid methyl ester (1), 3β-hydroxy-27- trans-caffeoyloxylup-20(29)-en-28-oic acid methyl ester (2), 3α-acetoxy-27- trans-caffeoyloxylup-20(29)-en-28-oic acid methyl ester (3), 3β-acetoxy-27- trans-caffeoyloxylup-20(29)-en-28-oic acid methyl ester (4), luotonin C (5), luotonin D (6), harmine (7), harmol (8), harmaline (9), deoxyvasicinone (10) and vasicinone (11). Compounds 1, 3 and 4 are novel triterpenoids, and these pentacyclic triterpenoids were evaluated for their cytotoxicity against the androgen-sensitive LNCaP and androgen-independent PC-3 human prostate cancer cells.

Synthesis and antiarrhythmic activity of (1,3-dimethyl-5-nitro-5-hexahydropyrimidinyl)-propionic acid methyl ester

2006 ◽  
Vol 40 (1) ◽  
pp. 29-31 ◽  
Author(s):  
R. R. Shakirov ◽  
N. N. Yarmukhamedov ◽  
L. I. Vlasova ◽  
N. Z. Baibulatova ◽  
R. Yu. Khisamutdinova ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Propionic Acid ◽  
Acid Methyl Ester ◽  
Antiarrhythmic Activity ◽  
Acid Methyl

scholarly journals Crystal structure of (S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionic acid methyl ester, C8H4NO2[CH(CH3)COOCH3]

1999 ◽  
Vol 214 (1) ◽  
pp. 107-108
Author(s):  
K. Peters ◽  
E.-M. Peters ◽  
A. G. Griesbeck ◽  
M. Oelgemöller ◽  
A. Bartoschek
Keyword(s):  
Crystal Structure ◽  
Methyl Ester ◽  
Propionic Acid ◽  
Acid Methyl Ester ◽  
Acid Methyl
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