scholarly journals PLGA nanoparticle preparations by emulsification and nanoprecipitation techniques: effects of formulation parameters

RSC Advances ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 4218-4231 ◽  
Author(s):  
Karol Yesenia Hernández-Giottonini ◽  
Rosalva Josefina Rodríguez-Córdova ◽  
Cindy Alejandra Gutiérrez-Valenzuela ◽  
Omar Peñuñuri-Miranda ◽  
Paul Zavala-Rivera ◽  
...  
Keyword(s):  
Solvent Evaporation ◽  
Formulation Parameters ◽  
Emulsification Solvent Evaporation ◽  
Plga Nanoparticle

This study presents the influence of the primary formulation parameters on the formation of poly-dl-lactic-co-glycolic nanoparticles by the emulsification-solvent evaporation, and the nanoprecipitation techniques.

scholarly journals Comparative Nanofabrication of PLGA-Chitosan-PEG Systems Employing Microfluidics and Emulsification Solvent Evaporation Techniques

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1882
Author(s):  
Divesha Essa ◽  
Yahya E. Choonara ◽  
Pierre P. D. Kondiah ◽  
Viness Pillay
Keyword(s):  
Surface Charge ◽  
Surface Properties ◽  
Surface Characteristics ◽  
Solvent Evaporation ◽  
Physical Interaction ◽  
Scanning Calorimetry ◽  
Particle Properties ◽  
Superior Surface ◽  
Poorly Soluble ◽  
Emulsification Solvent Evaporation

Poor circulation stability and inadequate cell membrane penetration are significant impediments in the implementation of nanocarriers as delivery systems for therapeutic agents with low bioavailability. This research discusses the fabrication of a biocompatible poly(lactide-co-glycolide) (PLGA) based nanocarrier with cationic and hydrophilic surface properties provided by natural polymer chitosan and coating polymer polyethylene glycol (PEG) for the entrapment of the hydrophobic drug disulfiram. The traditional emulsification solvent evaporation method was compared to a microfluidics-based method of fabrication, with the optimisation of the parameters for each method, and the PEGylation densities on the experimental nanoparticle formulations were varied. The size and surface properties of the intermediates and products were characterised and compared by dynamic light scattering, scanning electron microscopy and X-ray diffraction, while the thermal properties were investigated using thermogravimetric analysis and differential scanning calorimetry. Results showed optimal particle properties with an intermediate PEG density and a positive surface charge for greater biocompatibility, with nanoparticle surface characteristics shielding physical interaction of the entrapped drug with the exterior. The formulations prepared using the microfluidic method displayed superior surface charge, entrapment and drug release properties. The final system shows potential as a component of a biocompatible nanocarrier for poorly soluble drugs.

scholarly journals FORMULASI MIKROPARTIKEL BERPORI DALAM POLI (D,L-Laktida) SEBAGAI SCAFFOLDDENGAN TEKNIK EMULSIFIKASI PENGUAPAN PELARUT

2015 ◽  
Vol 4 (2) ◽  
pp. 7
Author(s):  
Lili Fitriani ◽  
Tri Suciati
Keyword(s):  
Particle Size ◽  
Sodium Bicarbonate ◽  
Solvent Evaporation ◽  
Burst Release ◽  
Target Tissue ◽  
Citric Acid Solution ◽  
Porous Microparticles ◽  
Optimum Formulation ◽  
Oil Water ◽  
Emulsification Solvent Evaporation

 ABSTRACT Poly (D,L-lactide acid) has been used as scaffold for tissue engineering. In this study, PDLLA microparticles were made into porous microparticles. Porous microparticles were proposed to reduce burst release of protein and to prevent diffusion of released protein into non-target tissue. Formulation of porous microparticles was made by water-oil-water (W1/O/W2) emulsification-solvent evaporation using gas foamed as porogen. Variations of the amount of sodium bicarbonate, volume of citric acid solution and time for homogenization were optimized to produce optimum formulation. Evaluation for this microparticles included morphology of particles, particle size distribution and porosity. Porous microparticle produced by ratio volume of acid : dichloromethane : poly(vynil alcohol) (PVA) = 1:3:3 and the ratio of  sodium bicarbonate : PDLLA = 2:3 was the optimum formulation.  Keywords :Porous Microparticles, PDLLA,Gas Foamed, Scaffold, Solvent Evaporation 

scholarly journals Polymeric Core-Shell Nanoparticles Prepared by Spontaneous Emulsification Solvent Evaporation and Functionalized by the Layer-by-Layer Method

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 496 ◽  
Author(s):  
Marta Szczęch ◽  
Krzysztof Szczepanowicz
Keyword(s):  
Polymeric Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Solvent Evaporation ◽  
Poly Lactic Acid ◽  
Core Shell ◽  
Layer By Layer ◽  
Shell Nanoparticles ◽  
Spontaneous Emulsification ◽  
Emulsification Solvent Evaporation ◽  
Core Shell Nanoparticles

The aim of our study was to develop a novel method for the preparation of polymeric core-shell nanoparticles loaded with various actives for biomedical applications. Poly(caprolactone) (PCL), poly(lactic acid) (PLA) and poly(lactide-co-glycolide) (PLGA) nanoparticles were prepared using the spontaneous emulsification solvent evaporation (SESE) method. The model active substance, Coumarin-6, was encapsulated into formed polymeric nanoparticles, then they were modified/functionalized by multilayer shells’ formation. Three types of multilayered shells were formed: two types of polyelectrolyte shell composed of biocompatible and biodegradable polyelectrolytes poly-L-lysine hydrobromide (PLL), fluorescently-labeled poly-L-lysine (PLL-ROD), poly-L-glutamic acid sodium salt (PGA) and pegylated-PGA (PGA-g-PEG), and hybrid shell composed of PLL, PGA, and SPIONs (superparamagnetic iron oxide nanoparticles) were used. Multilayer shells were constructed by the saturation technique of the layer-by-layer (LbL) method. Properties of our polymeric core-shell nanoparticle were optimized for bioimaging, passive and magnetic targeting.

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