scholarly journals Functional metabolomics using UPLC-Q/TOF-MS combined with ingenuity pathway analysis as a promising strategy for evaluating the efficacy and discovering amino acid metabolism as a potential therapeutic mechanism-related target for geniposide against alcoholic liver disease

RSC Advances ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 2677-2690 ◽  
Author(s):  
Shi Qiu ◽  
Ai-hua Zhang ◽  
Yu Guan ◽  
Hui Sun ◽  
Tian-lei Zhang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Amino Acid ◽  
Pathway Analysis ◽  
Alcoholic Liver Disease ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Promising Strategy ◽  
Therapeutic Mechanism ◽  
Functional Metabolomics ◽  
Tof Ms

Metabolomics has been used as a strategy to evaluate the efficacy of and potential targets for natural products.

Three-spot seahorse-derived peptide PAGPRGPA attenuates ethanol-induced oxidative stress in LO2 cells through MAPKs, Keap1/Nrf2 signalling pathway and amino acid metabolism

2021 ◽  
Author(s):  
Jie Shi ◽  
Xin Zhou ◽  
Ying Zhao ◽  
Xuemei Tang ◽  
Lu Feng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Amino Acid ◽  
Global Health ◽  
Alcoholic Liver Disease ◽  
Liver Diseases ◽  
Amino Acid Metabolism ◽  
Bioactive Peptides ◽  
Acid Metabolism ◽  
Marine Organisms

Various types of liver diseases such as the alcoholic liver disease (ALD) are still global health problems. Bioactive peptides isolated from people, marine organisms, animals and plants have shown hepatoprotective...

scholarly journals Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease

Amino Acids ◽  
2014 ◽  
Vol 47 (3) ◽  
pp. 603-615 ◽  
Author(s):  
April D. Lake ◽  
Petr Novak ◽  
Petia Shipkova ◽  
Nelly Aranibar ◽  
Donald G. Robertson ◽  
...  
Keyword(s):  
Liver Disease ◽  
Amino Acid ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Nonalcoholic Fatty Liver ◽  
Branched Chain Amino Acid ◽  
Branched Chain

scholarly journals Plasma Metabolic Profiling Analysis of Gout Party on Acute Gout Arthritis Rats Based on UHPLC–Q–TOF/MS Combined with Multivariate Statistical Analysis

2019 ◽  
Vol 20 (22) ◽  
pp. 5753 ◽  
Author(s):  
Yuming Wang ◽  
Chenghao Bi ◽  
Wentao Pang ◽  
Yuechen Liu ◽  
Yu Yuan ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Amino Acid ◽  
Energy Metabolism ◽  
Fatty Acid Metabolism ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Gouty Arthritis ◽  
Enoic Acid ◽  
Plasma Samples ◽  
Tof Ms

Gout Party is a Chinese medicine prescription composed of Aconiti Lateralis Radix Praeparaia, Aconiti Radix Cocta, Cremastrae Pseudobulbus Pleiones Pseudobulbus, Smilacis Glabrae Rhizoma, Rehmanniae Radix, and Glycyrrhizae Radix et Rhizoma, which can relieve joint pain caused by gouty arthritis (GA) and rheumatoid, and has a therapeutic effect on acute gouty arthritis (AGA). However, little information is available on the molecular biological basis and therapeutic mechanism of Gout Party for the treatment of AGA. AGA model was established by injecting sodium urate, and colchicine served as a positive control drug. We established a metabolomic method based on ultra-high-performance liquid chromatography–tandem quadrupole/time-of-flight mass spectrometry (UHPLC–Q–TOF/MS) to analyze the plasma samples of model group rats and blank group rats. Multiple statistical analyses, including principal component analysis (PCA) and partial least square discrimination analysis (PLS-DA), were used to examine metabolite profile changes in plasma samples. Finally, we identified 2–ketobutyric acid, 3–hexenedioic acid, but–2–enoic acid, and so on; 22 endogenous metabolites associated with AGA. After successful molding, we found that 2–ketobutyric acid, 3–hexenedioic acid, but–2–enoic acid, argininic acid, galactonic acid, lactic acid, equol 4′–O–glucuronide, deoxycholic acid glycine conjugate, glycocholic acid, sphinganine 1–phosphate, LPE (0:0/20:3), LPE (0:0/16:0), LPC (15:0) decreased significantly (p < 0.05 or p < 0.01), alanine, erythrulose, 3–dehydrocarnitine, m–methylhippuric acid, 3–hydroxyoctanoic acid, p–cresol sulfate, estriol 3–sulfate 16–glucuronide, 10–hydroxy–9–(phosphonooxy)octadecenoate, docosahexaenoic acid increased significantly (p < 0.05 or p < 0.01). After Gout Party treatment, 14 biomarkers had a tendency to normal conditions. These above biomarkers were mainly involved in fatty acid metabolism, bile acid metabolism, amino acid metabolism, and energy metabolism pathways. These results suggested that Gout Party exerted therapeutic effects of treating AGA by improving energy metabolism disorder and amino acid metabolism dysfunction, and attenuating fatty acid metabolism abnormal and inflammation. The results of this experiment provided a reference for revealing the metabolic mechanism produced by Gout Party in the treatment of AGA, but the subsequent studies need to be further improved and supported by relevant cell experiments and clinical experiments.

Amino acid metabolism in liver disease

1999 ◽  
Vol 2 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Eggert Holm ◽  
Oliver Sedlaczek ◽  
Eva Grips
Keyword(s):  
Liver Disease ◽  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism
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