scholarly journals Ultra-low concentration protein detection based on phenylalanine–Pd/SWCNT as a high sensitivity nanoreceptor

RSC Advances ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 2650-2660 ◽  
Author(s):  
Mehdi Yoosefian ◽  
Nazanin Etminan ◽  
Alfredo Juan ◽  
Elnaz Mirhaji
Keyword(s):  
Amino Acid ◽  
Early Detection ◽  
Protein Detection ◽  
High Sensitivity ◽  
Disease Diagnosis ◽  
Early Disease ◽  
Low Concentration ◽  
Disease Progress

Early detection of proteins could help to reduce disease progress. The amino acid hybrid with the Pd/SWCNT supporting enhanced transducer provides a high sensitivity biocompatible bioelectrode in nanobiosensors for use in early disease diagnosis.

scholarly journals SALIVA AND SALIVAOMICS IN THE DIAGNOSIS OF ORAL AND SYSTEMIC DISEASES: A REVIEW

2021 ◽  
pp. 8-12
Author(s):  
Sherly Ruth ◽  
Koduri Sridevi ◽  
Buduru Krishnaveni ◽  
Nalli Prasanth Kumar ◽  
Katru Sreekar ◽  
...  
Keyword(s):  
Health Care ◽  
Early Detection ◽  
Patient Care ◽  
Disease Diagnosis ◽  
Response To Therapy ◽  
Response To Treatment ◽  
Systemic Diseases ◽  
Early Disease ◽  
Early Disease Detection ◽  
Salivary Diagnostics

The quest for novel strategies in early disease detection and response to therapy is an essential ongoing process in health care setups.Along with other body fluids such as blood,mucus,urine,semen and vaginal fluids;saliva can also be considered for the detection of the disease.The Salivary diagnostics is a dynamic field that is being incorporated as part of disease diagnosis, clinical monitoring and for making important clinical decisions for patient care. This review presents the translational value of saliva as a credible clinical diagnostic biofluid in detection, early detection of the various diseases and response to treatment.

Nanomonitors: Electrical Immunoassays for Protein Biomarker Profiling

2008 ◽  
Vol 1106 ◽  
Author(s):  
Manish Bothara ◽  
Ravi K Reddy ◽  
Thomas Barrett ◽  
John Carruthers ◽  
Shalini Prasad
Keyword(s):  
Microelectrode Array ◽  
Performance Metrics ◽  
Point Of Care ◽  
High Sensitivity ◽  
Disease Diagnosis ◽  
Clinical Samples ◽  
Label Free ◽  
Early Disease ◽  
Alumina Membrane ◽  
Protein Biomarker

AbstractThe objective of this research is to develop a “point-of-care” device for early disease diagnosis through protein biomarker characterization. Here we present label-free, high sensitivity detection of proteins with the use of electrical immunoassays that we call Nanomonitors. The basis of the detection principle lies in the formation of an electrical double layer and its perturbations caused by proteins trapped in a nanoporous alumina membrane over a microelectrode array platform. High sensitivity and rapid detection of two inflammatory biomarkers, C-reactive protein (CRP) and Myeloperoxidase (MPO) in pure and clinical samples through label-free electrical detection were achieved. The performance metrics achieved by this device makes it suitable as a “lab-on-a-chip” device for protein biomarker profiling and hence early disease diagnosis.

scholarly journals Noninvasive Early Disease Diagnosis by Electronic-Nose and Related VOC-Detection Devices

Biosensors ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 73 ◽  
Author(s):  
Alphus Dan Wilson
Keyword(s):  
Early Detection ◽  
Electronic Nose ◽  
Disease Diagnosis ◽  
Plant Diseases ◽  
Research Articles ◽  
Special Issue ◽  
Early Disease ◽  
Invasive Pests ◽  
Detection And Diagnosis ◽  
Voc Detection

This editorial provides an overview and summary of recent research articles published in Biosensors journal, volumes 9 (2019) and 10 (2020), within the Special Issue “Noninvasive Early Disease Diagnosis”, which focused on recent sensors, biosensors, and clinical instruments developed for the noninvasive early detection and diagnosis of human, animal, and plant diseases or invasive pests. The six research articles included in this Special Issue provide examples of some of the latest electronic-nose (e-nose) and related volatile organic compound (VOC)-detection technologies, which are being tested and developed to improve the effectiveness and efficiency of innovative diagnostic methodologies for the early detection of particular diseases and pest infestations in living hosts, prior to symptom development.

Detector-C: A Blood-based IVD with High Sensitivity and Specificity for Early Detection and Screening of Colorectal Cancer

2010 ◽  
Vol 48 (08) ◽  
Author(s):  
A Rosenthal ◽  
H Köppen ◽  
R Musikowski ◽  
R Schwanitz ◽  
J Behrendt ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Detection ◽  
Sensitivity And Specificity ◽  
High Sensitivity

scholarly journals Nanopore Technology for the Application of Protein Detection

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1942
Author(s):  
Xiaoqing Zeng ◽  
Yang Xiang ◽  
Qianshan Liu ◽  
Liang Wang ◽  
Qianyun Ma ◽  
...  
Keyword(s):  
Single Molecule ◽  
Protein Detection ◽  
High Sensitivity ◽  
Single Molecule Detection ◽  
Sequence Detection ◽  
Fast Detection ◽  
Material Basis ◽  
Sensing Technology ◽  
Detection Technology ◽  
Structure Recognition

Protein is an important component of all the cells and tissues of the human body and is the material basis of life. Its content, sequence, and spatial structure have a great impact on proteomics and human biology. It can reflect the important information of normal or pathophysiological processes and promote the development of new diagnoses and treatment methods. However, the current techniques of proteomics for protein analysis are limited by chemical modifications, large sample sizes, or cumbersome operations. Solving this problem requires overcoming huge challenges. Nanopore single molecule detection technology overcomes this shortcoming. As a new sensing technology, it has the advantages of no labeling, high sensitivity, fast detection speed, real-time monitoring, and simple operation. It is widely used in gene sequencing, detection of peptides and proteins, markers and microorganisms, and other biomolecules and metal ions. Therefore, based on the advantages of novel nanopore single-molecule detection technology, its application to protein sequence detection and structure recognition has also been proposed and developed. In this paper, the application of nanopore single-molecule detection technology in protein detection in recent years is reviewed, and its development prospect is investigated.

High-sensitivity amino acid analysis of stained peptides and proteins from a sodium dedecyl sulphate-polyacrylamide slab gel

1986 ◽  
Vol 354 ◽  
pp. 463-470 ◽  
Author(s):  
S. Shoji ◽  
M. Ichikawa ◽  
T. Yamaoka ◽  
T. Funakoshi ◽  
Y. Kubota
Keyword(s):  
Amino Acid ◽  
Amino Acid Analysis ◽  
High Sensitivity

Virus induced hepatocellular carcinoma (HCC) and protein biomarkers

2021 ◽  
Author(s):  
Hamza Abbas Jaffari ◽  
Sumaira Mazhar
Keyword(s):  
Hepatocellular Carcinoma ◽  
Early Stage ◽  
Imaging Techniques ◽  
Disease Diagnosis ◽  
Protein Biomarkers ◽  
Early Disease ◽  
Detection Systems ◽  
Non Invasive ◽  
Viral Hepatitis B ◽  
Current Article

Hepatocellular carcinoma (HCC) is a standout amongst the most widely recognized cancers around the world, and just as the alcoholic liver disease it is also progressed by extreme viral hepatitis B or C. At the early stage of the disease, numerous patients are asymptomatic consequently late diagnosis of HCC occurs resulting in expensive surgical resection or transplantation. On the basis of the alpha fetoprotein (AFP) estimation, combined with the ultrasound and other sensitive imaging techniques used, the non-invasive detection systems are available. For early disease diagnosis and its use in the effective treatment of HCC patients, the identification of HCC biomarkers has provided a breakthrough utilizing the molecular genetics and proteomics. In the current article, most recent reports on the protein biomarkers of HBV or HCV-related HCC and their co-evolutionary association with liver cancer are reviewed.

Exerting Cost-Sensitive and Feature Creation Algorithms for Coronary Artery Disease Diagnosis

2012 ◽  
Vol 3 (1) ◽  
pp. 59-79 ◽  
Author(s):  
Roohallah Alizadehsani ◽  
Mohammad Javad Hosseini ◽  
Reihane Boghrati ◽  
Asma Ghandeharioun ◽  
Fahime Khozeimeh ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
High Sensitivity ◽  
Disease Diagnosis ◽  
Major Type ◽  
Support Vector ◽  
K Nearest Neighbors ◽  
Diagnostic Modality ◽  
Data Mining Algorithms ◽  
Artery Disease

One of the main causes of death the world over is the family of cardiovascular diseases, of which coronary artery disease (CAD) is a major type. Angiography is the principal diagnostic modality for the stenosis of heart arteries; however, it leads to high complications and costs. The present study conducted data-mining algorithms on the Z-Alizadeh Sani dataset, so as to investigate rule based and feature based classifiers and their comparison, and the reason for the effectiveness of a preprocessing algorithm on a dataset. Misclassification of diseased patients has more side effects than that of healthy ones. To this end, this paper employs 10-fold cross-validation on cost-sensitive algorithms along with base classifiers of Naïve Bayes, Sequential Minimal Optimization (SMO), K-Nearest Neighbors (KNN), Support Vector Machine (SVM), and C4.5 and the results show that the SMO algorithm yielded very high sensitivity (97.22%) and accuracy (92.09%) rates.

scholarly journals Cerium Oxide-Tungsten Oxide Core-Shell Nanowire-Based Microsensors Sensitive to Acetone

Biosensors ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 116 ◽  
Author(s):  
Milena Tomić ◽  
Milena Šetka ◽  
Ondřej Chmela ◽  
Isabel Gràcia ◽  
Eduard Figueras ◽  
...  
Keyword(s):  
Tungsten Oxide ◽  
Cerium Oxide ◽  
Chemical Vapor ◽  
Disease Diagnosis ◽  
Core Shell ◽  
Early Disease ◽  
Vacancy Defects ◽  
The Core ◽  
Enhanced Sensitivity ◽  
Volatile Organic

Gas sensitive cerium oxide-tungsten oxide core-shell nanowires are synthesized and integrated directly into micromachined platforms via aerosol assisted chemical vapor deposition. Tests to various volatile organic compounds (acetone, ethanol, and toluene) involved in early disease diagnosis demonstrate enhanced sensitivity to acetone for the core-shell structures in contrast to the non-modified materials (i.e., only tungsten oxide or cerium oxide). This is attributed to the high density of oxygen vacancy defects at the shell, as well as the formation of heterojunctions at the core-shell interface, which provide the modified nanowires with ‘extra’ chemical and electronic sensitization as compared to the non-modified materials.

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