scholarly journals pH-responsive polymeric vesicles from branched copolymers

RSC Advances ◽  
2019 ◽  
Vol 9 (70) ◽  
pp. 41031-41037
Author(s):  
Jinglun Zhou ◽  
Linlin Li ◽  
Weishan Wang ◽  
Yang Zhao ◽  
Shengyu Feng
Keyword(s):  
Glutamic Acid ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Ph Responsive ◽  
Branched Copolymers ◽  
Polymeric Vesicles ◽  
New Type ◽  
Branched Copolymer ◽  
Copolymer Poly

A new type of branched copolymer, poly(l-lactide)2-b-poly(l-glutamic acid), based on polypeptide PLGA is synthesized by the ring-opening polymerization of N-carboxyanhydride of γ-benzyl-l-glutamate with amino-terminated PLLA2–NH2 and subsequent deprotection.

A New Type of Ring-Opening Polymerization

1962 ◽  
Vol 27 (9) ◽  
pp. 3337-3340 ◽  
Author(s):  
Teruaki Mukaiyama ◽  
Tamotsu Fujisawa ◽  
Hiroyuki Nohira ◽  
Teruo Hyugaji
Keyword(s):  
Ring Opening ◽  
Ring Opening Polymerization ◽  
New Type

Folic acid targeted pH-responsive amphiphilic polymer nanoparticles conjugated with near infrared fluorescence probe for imaging-guided drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (46) ◽  
pp. 40312-40322 ◽  
Author(s):  
Liyi Fu ◽  
Le Liu ◽  
Zheng Ruan ◽  
Houbing Zhang ◽  
Lifeng Yan
Keyword(s):  
Folic Acid ◽  
Ring Opening ◽  
Near Infrared ◽  
Fluorescence Probe ◽  
Click Reaction ◽  
Raft Polymerization ◽  
Ring Opening Polymerization ◽  
Amphiphilic Polymer ◽  
Polymer Nanoparticles ◽  
Ph Responsive

A novel folic acid targeted pH-responsive amphiphilic polymer conjugated with near infrared (NIR) probe has been synthesized by the combination of RAFT polymerization, ring-opening polymerization of N-carboxy anhydride (NCA) and click reaction.

Self-Assembly of Amphiphilic Block Copolymer in Aqueous Solutions Tuned by Host-Guest Inclusion Complexation

2012 ◽  
Vol 487 ◽  
pp. 663-667
Author(s):  
Yu Long Shuai ◽  
Mi Zhou ◽  
Xin Qian
Keyword(s):  
Block Copolymer ◽  
Self Assembly ◽  
Ring Opening ◽  
Chain Transfer ◽  
Gene Transfection ◽  
Inclusion Complexation ◽  
Ring Opening Polymerization ◽  
Isopropyl Acrylamide ◽  
Reversible Addition ◽  
Copolymer Poly

The block copolymer poly (ε-caprolactone)-b-poly (N-isopropyl acrylamide) (PCL-b-PNIPAM) is synthesized via the combination of ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer (RAFT). PCL-b-PNIPAM can self-assemble into the micelles taking PCL as the cores and PNIPAM as the shells. Add α-CD into the micelles, because the inclusion complexation of α-CD to PCL chains and phenols is stronger than that to PCL, to regulate the hydrophilic and hydrophobic features of PCL chain. So PCL-b-PNIPAM block copolymers have potential application in drug delivery and gene transfection.

Phase Separation in Thermosetting Blends of Epoxy Resin with PS-b-PCL and PI-Si Block Copolymers

2014 ◽  
Vol 936 ◽  
pp. 95-98
Author(s):  
Jin Dian Ding ◽  
Wei Zhen Li ◽  
Tian Qi Jiang ◽  
Zong Lian Xia ◽  
Wen Jun Gan
Keyword(s):  
Phase Separation ◽  
Block Copolymers ◽  
Diblock Copolymer ◽  
Ring Opening ◽  
Microphase Separation ◽  
Ring Opening Polymerization ◽  
Lithium Aluminum ◽  
Ps I ◽  
Atomic Transfer Radical Polymerization ◽  
Copolymer Poly

Amphiphilic Diblock Copolymer Poly(styrene-b-ε-Caprolactone) were Synthesized. Firstly, Polystyrene was Synthesized via Sequential Atomic Transfer Radical Polymerization (ATRP), and then the Tetra Hydro Lithium Aluminum (LiAlH4) was Used as a Reducing Agent in Tetra Hydro (THF) to Reduce Polystyrene to the Pre-Polymer Monohydroxy-Terminated Polystyrene (PS-OH). as Following, Amphiphilic Diblock were Obtained by Ring Opening Polymerization. and the Structure of Diblock Polymer was Investigated by FTIR. Furthermore, the Block Copolymers were Added into the Mixture of Epoxy and me-THPA. and the Optical Microscopy(OM) Shows that the Microphase Separation Occured in this System and the PS-b-PCL can Promote the Phase Separation in the System.

Synthesis and sequence-controlled self-assembly of amphiphilic triblock copolymers based on functional poly(ethylene glycol)

2017 ◽  
Vol 8 (45) ◽  
pp. 6964-6971 ◽  
Author(s):  
Yanxin Qi ◽  
Bin Li ◽  
Yupeng Wang ◽  
Yubin Huang
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Ring Opening ◽  
Glycidyl Ether ◽  
Ring Opening Polymerization ◽  
Poly Ethylene Glycol ◽  
Amphiphilic Triblock Copolymer ◽  
Allyl Glycidyl Ether ◽  
Poly Ethylene ◽  
Copolymer Poly

Given the increasing prosperity of multifunctional poly(ethylene glycol) (mf-PEG), an amphiphilic triblock copolymer, poly(ethylene glycol)-block-poly(ε-caprolactone)-block-poly(allyl glycidyl ether) (mPEG-PCL-PAGE), was synthesized by a combination of living ring-opening polymerization (ROP) and click chemistry.

Study of Synthesis and Properties on Poly L-Glutamate Initiated by Aniline

2011 ◽  
Vol 284-286 ◽  
pp. 2110-2113 ◽  
Author(s):  
Zhi Ming Zhang ◽  
Shi Qian Wei ◽  
Li Hua Han
Keyword(s):  
Glutamic Acid ◽  
Aromatic Compounds ◽  
Ring Opening ◽  
Raw Materials ◽  
Gel Permeation Chromatography ◽  
Ring Opening Polymerization ◽  
Benzyl Ester ◽  
Molar Ratio ◽  
Basic Unit ◽  
Anhydrous Dichloromethane

With L-glutamic acid as raw materials, N-carboxy-L-glutamic acid-benzyl-anhydride (BLG-NCA) was synthesized by triphosgene. With aniline as the initiator in the anhydrous dichloromethane, ring-opening polymerization of BLG-NCA was initiated, poly-l-glutamic acid benzyl ester was obtained. The amount of initiators, Molar ratio of monomer/initiators, reaction temperature and reaction time to the effect of poly-l-glutamic acid benzyl ester in the ring-opening polymerization of BLG-NCA were studied. Through infrared spectroscopy, gel permeation chromatography (GPC) analysis and characteristic viscosity method, polymerization product was characterized and analysized. Results showed that in dichloromethane, ring-opening polymerization of BLG-NCA could be initiated by aniline, which expands greater scope of the initiators of poly-l-glutamate to aromatic compounds, and the introduction of the active group provided by aromatic compounds make it possible for the advanced development of block copolymer with poly-l-glutamic acid as a basic unit.

Synthesis of Poly L-Glutamate Initiated by Triethanolamine

2012 ◽  
Vol 450-451 ◽  
pp. 26-29
Author(s):  
Zhi Ming Zhang ◽  
Shi Qian Wei ◽  
Ting Ting Li ◽  
Li Hua Han
Keyword(s):  
Glutamic Acid ◽  
Ring Opening ◽  
Raw Materials ◽  
Ring Opening Polymerization ◽  
Benzyl Ester ◽  
Molar Ratio ◽  
Anhydrous Dichloromethane ◽  
H Nmr ◽  
Polymerization Product ◽  
Ubbelohde Viscometer

With L-glutamic acid as raw materials, N-carboxy-L-glutamic acid-benzyl-anhydride (BLG-NCA) was synthesized by triethanolamine. With triethanolamine as the initiator in the anhydrous dichloromethane, ring-opening polymerization of BLG-NCA was initiated, poly-l-glutamic acid benzyl ester was obtained. The amount of initiators, molar ratio of monomer/initiators, reaction temperature and reaction time to the effect of poly-l-glutamic acid benzyl ester in the ring-opening polymerization of BLG-NCA were studied. At last, poly L-glutamate was got, after the debenzylation in HBr solution. Through infrared spectroscopy, Ubbelohde viscometer, 1H NMR spectra, polymerization product was characterized and analysized. Results showed that in dichloromethane, ring-opening polymerization of BLG-NCA could be initiated by triethanolamine.

Preparation of the Amphiphilic Copolymer of Poly(ethyleneoxid-co-glycidol)-Graft-Poly(lactide) and their Extraction for Dyes

2012 ◽  
Vol 482-484 ◽  
pp. 1912-1916 ◽  
Author(s):  
Xin Zhao ◽  
Kun Yan Sui ◽  
Hong Chao Liang ◽  
Yu Jin Li ◽  
Yang Zhang ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Ring Opening ◽  
Triethylene Glycol ◽  
Ring Opening Polymerization ◽  
Ethyl Vinyl Ether ◽  
Ethyl Vinyl ◽  
Poly Ethylene Oxide ◽  
Acidic Conditions ◽  
Poly Ethylene ◽  
Copolymer Poly

A well-defined graft copolymer poly(ethylene oxide-co-glycidol)-graft-Poly(lactide) [poly(EO-co-Gly)-g-PLA] of poly(ethylene oxide-co-glycidol) [(poly(EO-co-Gly)] as main chain and poly(lactide) (PLA) as the side chain was successfully prepared via combination of anionic polymerization and ring-opening polymerization. The glycidol was protected by ethyl vinyl ether first to form 2, 3-epoxypropyl-1-ethoxyethyl ether (EPEE), and then copolymerized with EO by initiation with the mixture of diphenylmethylpotassium and triethylene glycol to obtain the well-defined poly(EO-co-EPEE). The latter was hydrolyzed in the acidic conditions and then coordination-insertion ring-opening polymerization of lactide(LA) with poly(EO-co-Gly) was completed. The object products and intermediates were characterized by 1HNMR, MALDI-TOF-MS and GPC in detail. The experimental results confirmed that poly(EO-co-Gly)-g-PLA showed strong conjugation ability with the dyes.

Organo-Catalyzed Ring Opening Polymerization of a 1,4-Dioxane-2,5-dione Deriving from Glutamic Acid

2010 ◽  
Vol 11 (8) ◽  
pp. 1921-1929 ◽  
Author(s):  
Olivier Thillaye du Boullay ◽  
Nathalie Saffon ◽  
Jean-Pierre Diehl ◽  
Blanca Martin-Vaca ◽  
Didier Bourissou
Keyword(s):  
Glutamic Acid ◽  
Ring Opening ◽  
Ring Opening Polymerization
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