scholarly journals Biofunctionalization of zirconia with cell-adhesion peptides via polydopamine crosslinking for soft tissue engineering: effects on the biological behaviors of human gingival fibroblasts and oral bacteria

RSC Advances ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 6200-6212 ◽  
Author(s):  
Zhen Yang ◽  
Mingyue Liu ◽  
Yang Yang ◽  
Miao Zheng ◽  
Yang Yang ◽  
...  

Biofunctionalization of zirconia with cell-adhesion peptides via polydopamine and its effect on HGFs/bacterial adhesion for enhanced soft tissue seal.

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5229
Author(s):  
Yuchen Sun ◽  
Ran Lu ◽  
Jingming Liu ◽  
Xin Wang ◽  
Haitao Dong ◽  
...  

The soft tissue sealing at the transmucal portion of implants is vital for the long-term stability of implants. Hydrogenated titanium nanotubes (H2-TNTs) as implant surface treatments were proved to promote the adhesion of human gingival fibroblasts (HGFs) and have broad usage as drug delivery systems. Bovine serum albumin (BSA) as the most abundant albumin in body fluid was crucial for cell adhesion and was demonstrated as a normal loading protein. As the first protein arriving on the surface of the implant, albumin plays an important role in initial adhesion of soft tissue cells, it is also a common carrier, transferring and loading different endogenous and exogenous substances, ions, drugs, and other small molecules. The aim of the present work was to investigate whether BSA-loaded H2-TNTs could promote the early adhesion of HGFs; H2-TNTs were obtained by hydrogenated anodized titanium dioxide nanotubes (TNTs) in thermal treatment, and BSA was loaded in the nanotubes by vacuum drying; our results showed that the superhydrophilicity of H2-TNTs is conducive to the loading of BSA. In both hydrogenated titanium nanotubes and non-hydrogenated titanium nanotubes, a high rate of release was observed over the first hour, followed by a period of slow and sustained release; however, BSA-loading inhibits the early adhesion of human gingival fibroblasts, and H2-TNTs has the best promoting effect on cell adhesion. With the release of BSA after 4 h, the inhibitory effect of BSA on cell adhesion was weakened.


Biomaterials ◽  
2004 ◽  
Vol 25 (27) ◽  
pp. 5857-5866 ◽  
Author(s):  
Richard M. Day ◽  
Aldo R. Boccaccini ◽  
Sandra Shurey ◽  
Judith A. Roether ◽  
Alastair Forbes ◽  
...  

Author(s):  
Mariana Carmen Chifiriuc ◽  
Anton Ficai ◽  
Alexandru Mihai Grumezescu ◽  
Lia-Mara Ditu ◽  
Marcela Popa ◽  
...  

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