scholarly journals Detection of β-alanyl aminopeptidase as a biomarker for Pseudomonas aeruginosa in the sputum of patients with cystic fibrosis using exogenous volatile organic compound evolution

RSC Advances ◽  
2020 ◽  
Vol 10 (18) ◽  
pp. 10634-10645 ◽  
Author(s):  
Ryan Thompson ◽  
Dominic Stephenson ◽  
Hannah E. Sykes ◽  
John D. Perry ◽  
Stephen P. Stanforth ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Organic Compound ◽  
Volatile Organic Compound ◽  
Analytical Method ◽  
Lung Transplant ◽  
Transplant Patients ◽  
Volatile Organic ◽  
Alanyl Aminopeptidase

A novel, rapid and sensitive analytical method has been developed and applied to 105 sputum samples from patients with cystic fibrosis, including 5 samples from post-lung transplant patients.

scholarly journals Volatile organic compound breath signatures of children with cystic fibrosis by real-time SESI-HRMS

2020 ◽  
Vol 6 (1) ◽  
pp. 00171-2019 ◽  
Author(s):  
Ronja Weber ◽  
Naemi Haas ◽  
Astghik Baghdasaryan ◽  
Tobias Bruderer ◽  
Demet Inci ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
High Resolution ◽  
Organic Compound ◽  
Real Time ◽  
Volatile Organic Compound ◽  
Lung Damage ◽  
Support Vector ◽  
P Value ◽  
Large Set ◽  
Volatile Organic

Early pulmonary infection and inflammation result in irreversible lung damage and are major contributors to cystic fibrosis (CF)-related morbidity. An easy to apply and noninvasive assessment for the timely detection of disease-associated complications would be of high value. We aimed to detect volatile organic compound (VOC) breath signatures of children with CF by real-time secondary electrospray ionisation high-resolution mass spectrometry (SESI-HRMS).A total of 101 children, aged 4–18 years (CF=52; healthy controls=49) and comparable for sex, body mass index and lung function were included in this prospective cross-sectional study. Exhaled air was analysed by a SESI-source linked to a high-resolution time-of-flight mass spectrometer. Mass spectra ranging from m/z 50 to 500 were recorded.Out of 3468 m/z features, 171 were significantly different in children with CF (false discovery rate adjusted p-value of 0.05). The predictive ability (CF versus healthy) was assessed by using a support-vector machine classifier and showed an average accuracy (repeated cross-validation) of 72.1% (sensitivity of 77.2% and specificity of 67.7%).This is the first study to assess entire breath profiles of children with SESI-HRMS and to extract sets of VOCs that are associated with CF. We have detected a large set of exhaled molecules that are potentially related to CF, indicating that the molecular breath of children with CF is diverse and informative.

scholarly journals Volatile organic compound signature from co-culture of lung epithelial cell line with Pseudomonas aeruginosa

The Analyst ◽  
2018 ◽  
Vol 143 (13) ◽  
pp. 3148-3155 ◽  
Author(s):  
Oluwasola Lawal ◽  
Hugo Knobel ◽  
Hans Weda ◽  
Lieuwe D. Bos ◽  
Tamara M. E. Nijsen ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Volatile Organic Compounds ◽  
Organic Compound ◽  
Epithelial Cell ◽  
Organic Compounds ◽  
Volatile Organic Compound ◽  
Epithelial Cell Line ◽  
Diagnostic Biomarkers ◽  
Lung Epithelial ◽  
Volatile Organic

Bacterial volatile organic compounds have the potential to be utilised as diagnostic biomarkers for infections.

scholarly journals P230 Exposure to cigarette smoke in a cystic fibrosis cohort - distinctive volatile organic compound profiles

2019 ◽  
Vol 18 ◽  
pp. S122
Author(s):  
T. Goddard ◽  
N. Darmawardana ◽  
R. Yazbek ◽  
J. Martin ◽  
J. Morton ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Organic Compound ◽  
Cigarette Smoke ◽  
Volatile Organic Compound ◽  
Volatile Organic

scholarly journals Detection of Pseudomonas aeruginosa in sputum headspace through volatile organic compound analysis

2012 ◽  
Vol 13 (1) ◽  
pp. 87 ◽  
Author(s):  
Pieter C Goeminne ◽  
Thomas Vandendriessche ◽  
Johan Van Eldere ◽  
Bart M Nicolai ◽  
Maarten LATM Hertog ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Organic Compound ◽  
Volatile Organic Compound ◽  
Volatile Organic

scholarly journals 118 Detection of Pseudomonas aeruginosa in sputum of bronchiectatic patients through volatile organic compound analysis

2012 ◽  
Vol 11 ◽  
pp. S86
Author(s):  
P.C. Goeminne ◽  
T. Vandendriessche ◽  
J. Van Eldere ◽  
B.M. Nicolai ◽  
M.L.A.T.M. Hertog ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Organic Compound ◽  
Volatile Organic Compound ◽  
Volatile Organic

Pilot plant plasma-catalytic system for the decomposition of a volatile organic compound

2016 ◽  
Vol 15 (3) ◽  
pp. 251-259
Author(s):  
Shreedhar Devkota ◽  
◽  
Jin Oh Jo ◽  
Dong Lyong Jang ◽  
Young Jin Hyun ◽  
...  
Keyword(s):  
Organic Compound ◽  
Catalytic System ◽  
Volatile Organic Compound ◽  
Pilot Plant ◽  
Volatile Organic
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