scholarly journals Different phase-dominated chiral assembly of polyfluorenes induced by chiral solvation: axial and supramolecular chirality

RSC Advances ◽  
2019 ◽  
Vol 9 (65) ◽  
pp. 38257-38264 ◽  
Author(s):  
Shuai Li ◽  
Tengfei Miao ◽  
Xiaoxiao Cheng ◽  
Yin Zhao ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Alkyl Chain ◽  
Axial Chirality ◽  
Supramolecular Chirality ◽  
Side Alkyl Chain

The chiral solvation induced chirality in achiral polyfluorenes showed the axial chirality for PF2/6 with branched side alkyl chain, but supramolecular chirality for PF8 with linear side alkyl chain.

Interaction Types in C6H5(CH2)nOH–CO2 (n = 0–4) Determined by the Length of the Side Alkyl Chain

2021 ◽  
pp. 149-155
Author(s):  
Hao Wang ◽  
Junhua Chen ◽  
Yang Zheng ◽  
Daniel A. Obenchain ◽  
Xuefang Xu ◽  
...  
Keyword(s):  
Alkyl Chain ◽  
Interaction Types ◽  
Side Alkyl Chain

scholarly journals Preparation of Benzalkonium Salts Differing in the Length of a Side Alkyl Chain

Molecules ◽  
2007 ◽  
Vol 12 (10) ◽  
pp. 2341-2347 ◽  
Author(s):  
Kamil Kuca ◽  
Jan Marek ◽  
Petr Stodulka ◽  
Kamil Musilek ◽  
Petra Hanusova ◽  
...  
Keyword(s):  
Alkyl Chain ◽  
Side Alkyl Chain

Designing silica xerogels containing RTIL for CO2 capture and CO2/CH4 separation: Influence of ILs anion, cation and cation side alkyl chain length and ramification

2020 ◽  
Vol 268 ◽  
pp. 110340 ◽  
Author(s):  
Leonardo M. dos Santos ◽  
Franciele L. Bernard ◽  
Bárbara B. Polesso ◽  
Ingrid S. Pinto ◽  
Claudio C. Frankenberg ◽  
...  
Keyword(s):  
Chain Length ◽  
Co2 Capture ◽  
Alkyl Chain ◽  
Alkyl Chain Length ◽  
Silica Xerogels ◽  
Side Alkyl Chain

scholarly journals A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Cinzia Citti ◽  
Pasquale Linciano ◽  
Fabiana Russo ◽  
Livio Luongo ◽  
Monica Iannotta ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Cannabis Sativa ◽  
Alkyl Chain ◽  
Binding Activity ◽  
Side Chain ◽  
Main Compound ◽  
Pharmacological Test ◽  
Side Alkyl Chain

Abstract(-)-Trans-Δ9-tetrahydrocannabinol (Δ9-THC) is the main compound responsible for the intoxicant activity of Cannabis sativa L. The length of the side alkyl chain influences the biological activity of this cannabinoid. In particular, synthetic analogues of Δ9-THC with a longer side chain have shown cannabimimetic properties far higher than Δ9-THC itself. In the attempt to define the phytocannabinoids profile that characterizes a medicinal cannabis variety, a new phytocannabinoid with the same structure of Δ9-THC but with a seven-term alkyl side chain was identified. The natural compound was isolated and fully characterized and its stereochemical configuration was assigned by match with the same compound obtained by a stereoselective synthesis. This new phytocannabinoid has been called (-)-trans-Δ9-tetrahydrocannabiphorol (Δ9-THCP). Along with Δ9-THCP, the corresponding cannabidiol (CBD) homolog with seven-term side alkyl chain (CBDP) was also isolated and unambiguously identified by match with its synthetic counterpart. The binding activity of Δ9-THCP against human CB1 receptor in vitro (Ki = 1.2 nM) resulted similar to that of CP55940 (Ki = 0.9 nM), a potent full CB1 agonist. In the cannabinoid tetrad pharmacological test, Δ9-THCP induced hypomotility, analgesia, catalepsy and decreased rectal temperature indicating a THC-like cannabimimetic activity. The presence of this new phytocannabinoid could account for the pharmacological properties of some cannabis varieties difficult to explain by the presence of the sole Δ9-THC.

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