scholarly journals Pre-clinical pharmacokinetic and pharmacodynamic modelling study of 4-hydroxyisoleucine using validated ultra-performance liquid chromatography-tandem mass spectrometry

RSC Advances ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 5525-5532
Author(s):  
Geetika Wadhwa ◽  
Kowthavarapu Venkata Krishna ◽  
Rajeev Taliyan ◽  
Neeraj Tandon ◽  
Satyapal Singh Yadav ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Clinical Pharmacokinetic ◽  
Ultra Performance Liquid Chromatography ◽  
Tandem Mass ◽  
Pharmacodynamic Modelling ◽  
Chromatography Tandem Mass Spectrometry ◽  
Hypolipidemic Agent ◽  
Liquid Chromatography Tandem Mass

A reliable and sensitive UPLC-MS/MS based method has been developed for the estimation of 4-hydroxyisoleucine, a potent insulinotropic and hypolipidemic agent.

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