scholarly journals Panax notoginseng saponins regulate VEGF to suppress esophageal squamous cell carcinoma progression via DVL3-mediated Wnt/β-catenin signaling

RSC Advances ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 3256-3265 ◽  
Author(s):  
Xiaoqi Chen ◽  
Zhuan Lv ◽  
Chuanlei Zhang ◽  
Xinting Wang ◽  
Yunxia Zhao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Panax Notoginseng ◽  
Panax Notoginseng Saponins ◽  
Vegf Expression

PNS regulate VEGF expression to suppress ESCC progression via the DVL3-mediated Wnt/β-catenin signaling pathway.

scholarly journals Retraction: Panax notoginseng saponins regulate VEGF to suppress esophageal squamous cell carcinoma progression via DVL3-mediated Wnt/β-catenin signaling

RSC Advances ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 6258-6258
Author(s):  
Laura Fisher
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Panax Notoginseng ◽  
Panax Notoginseng Saponins

Retraction of ‘Panax notoginseng saponins regulate VEGF to suppress esophageal squamous cell carcinoma progression via DVL3-mediated Wnt/β-catenin signaling’ by Xiaoqi Chen et al., RSC Adv., 2020, 10, 3256–3265, DOI: 10.1039/C9RA07830D.

Prognostic value of VEGF expression in primary esophageal squamous cell carcinoma

2004 ◽  
Vol 16 (2) ◽  
pp. 85-89 ◽  
Author(s):  
Wei-guo Xu ◽  
Guo-li Yang ◽  
Li-xin Zhou ◽  
Yu-quan Xie ◽  
Li-jian Zhang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Vegf Expression

scholarly journals Downregulation of AAA-domain-containing protein 2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway

2020 ◽  
Vol 319 (1) ◽  
pp. C93-C104
Author(s):  
Nuo Li ◽  
Yang Yu ◽  
Baoming Wang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Colony Formation ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway

Esophageal squamous cell carcinoma (ESCC) ranks among the five most common cancers in China and has a five-year survival rate of less than 15%. The transcription factor ATPase-family AAA-domain-containing protein 2 (ATAD2) has potential as a therapeutic target in various tumors, and microarray-based gene expression profiling reveals dysregulation of ATAD2 specifically in ESCC. Here we investigated whether ATAD2 could mediate a regulation of cancer stem cell (CSC) biological functions in ESCC. Immunohistochemical staining, reverse transcription quantitative polymerase chain reaction, and Western blot assays all revealed upregulation of ATAD2 in ESCC tissues and cell lines, which furthermore correlated with progression of ESCC. In loss-of-function experiments, silencing of ATAD2 inhibited activation of the Hedgehog signaling pathway, as indicated by reduced expression of glioma-associated oncogene family zinc finger 1 (Gli1), smoothened frizzled class receptor (SMO), and patched 1 (PTCH1). Investigations with 5-ethynyl-2′-deoxyuridine (EdU), Transwell assay, scratch test, flow cytometry, and colony formation assay showed that silencing of ATAD2 or inhibiting the Hedgehog signaling decreased the proliferation, invasion, and migration abilities along with colony formation, but elevated the apoptosis rate of CSCs. Furthermore, in vivo experiments validated the suppressive effect of siRNA-mediated ATAD2 silencing on tumor growth in nude mice. Thus, downregulation of ATAD2 can seemingly restrain the malignant phenotypes of ESCC cells through inhibition of the Hedgehog signaling pathway.

TWIST1 correlates with Notch signaling pathway to develop esophageal squamous cell carcinoma

2020 ◽  
Vol 474 (1-2) ◽  
pp. 181-188 ◽  
Author(s):  
Yasaman Fahim ◽  
Mozhgan Yousefi ◽  
Mohammad Hossein Izadpanah ◽  
Mohammad Mahdi Forghanifard
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Notch Signaling ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Notch Signaling Pathway

ANRIL inhibits p15INK4b through the TGFβ1 signaling pathway in human esophageal squamous cell carcinoma

2014 ◽  
Vol 289 (1-2) ◽  
pp. 91-96 ◽  
Author(s):  
Deyu Chen ◽  
Zhaoyue Zhang ◽  
Chaoming Mao ◽  
Yuepeng Zhou ◽  
Lichao Yu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell
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