scholarly journals A minimal structural variation can overcome tumour resistance of oxaliplatin: the case of 4,5-dehydrogenation of the cyclohexane ring

RSC Advances ◽  
2019 ◽  
Vol 9 (56) ◽  
pp. 32448-32452 ◽  
Author(s):  
Paride Papadia ◽  
Valentina Gandin ◽  
Alessandra Barbanente ◽  
Alessandro G. Ruello ◽  
Cristina Marzano ◽  
...  
Keyword(s):  
Double Bond ◽  
Structural Variation ◽  
Cyclohexane Ring ◽  
Anticancer Compounds ◽  
New Family

A new family of anticancer compounds has been derived from oxaliplatin by inserting a double-bond between carbons 4 and 5 of the 1,2-diaminocyclohexane ring.

scholarly journals (2S,4S)-2-[(S,E)-2-Bromo-1-nitromethyl-3-phenylallyl]-4-methylcyclohexanone

2012 ◽  
Vol 68 (4) ◽  
pp. o1253-o1253
Author(s):  
Long Zhao ◽  
Chao Wu ◽  
Wen-Zeng Weng ◽  
Chu-Xia Yan ◽  
Ai-Bao Xia
Keyword(s):  
Crystal Structure ◽  
Double Bond ◽  
Chair Conformation ◽  
Cyclohexane Ring ◽  
Chiral Centers

The crystal structure of the title compoud, C17H20BrNO3, contains three chiral centers, which all exhibit anSconfiguration. The C=C double bond has anEconformation. The cyclohexane ring is in a chair conformation. In the crystal, molecules are linked by weak N—O...Br interactions [O...Br = 3.136 (4) Å].

Synthesis and stereochemistry of hydrogenated 1,1,4,4,7a-pentamethylindenes

1980 ◽  
Vol 58 (17) ◽  
pp. 1810-1820 ◽  
Author(s):  
Alan Francis Thomas ◽  
Michel Ozainne ◽  
Renée Guntz-Dubini
Keyword(s):  
Double Bond ◽  
Cyclohexane Ring ◽  
Wittig Reactions

Ease of methylation of hydrogenated 2H-inden-2-ones depends on the presence of a double bond in the cyclohexane ring, and occurs readily with compound 20 but not with 10. Differences of reactivity are also noted in Wittig reactions. Most reactions of the system are highly stereoselective, and the stereochemistry of hydrogenated indenes is discussed.

scholarly journals Crystal structure of a bioactive sesquiterpene isolated fromArtemisia reticulata

2016 ◽  
Vol 72 (4) ◽  
pp. 460-462
Author(s):  
A. K. Bauri ◽  
Sabine Foro ◽  
Nhu Quynh Nguyen Do
Keyword(s):  
Crystal Structure ◽  
Double Bond ◽  
Hydrogen Bonds ◽  
Silica Gel ◽  
Title Compound ◽  
Chair Conformation ◽  
Cyclohexane Ring ◽  
Exocyclic Double Bond ◽  
Compound C ◽  
Cyclopentane Ring

The title compound, C15H24O2{systematic name: 1-[6-hydroxy-7-(propan-2-yl)-4-methylidene-2,3,3a,4,5,6,7,7a-octahydro-1H-inden-1-yl]ethanone} was isolated fromA. reticulataby column chromatography over silica gel by gradient solvent elution. The molecule comprises a bicyclo[4.3.0]nonane ring bearing acetoxy, hydroxy and isopropyl substituents, and an exocyclic double bond on the cyclohexane ring. In the bicyclic skeleton, the cyclohexane ring adopts a chair conformation ring and the cyclopentane ring is in an envelope conformation. In the crystal, molecules are linked by O—H...O hydrogen bonds, forming chains along [010]. These chains are cross-linked by C—H...O hydrogen bonds.

scholarly journals Crystal structure of (E)-2-[3-(tert-butyl)-2-hydroxybenzylidene]-N-cyclohexylhydrazine-1-carbothioamide

2018 ◽  
Vol 74 (10) ◽  
pp. 1460-1462 ◽  
Author(s):  
Md. Azharul Arafath ◽  
Huey Chong Kwong ◽  
Farook Adam ◽  
Mohd. R. Razali
Keyword(s):  
Crystal Structure ◽  
Double Bond ◽  
Hydrogen Bonds ◽  
Benzene Ring ◽  
Title Compound ◽  
Chair Conformation ◽  
Cyclohexane Ring ◽  
Compound C ◽  
Similar Conformation ◽  
Ring Motif

In the title compound, C18H27N3OS, the cyclohexane ring has a chair conformation. The azomethine C=N double bond has an E configuration. The nearly planar hydrazinecarbothioamide moiety and substituted benzene ring are twisted by 31.13 (5)° relative to each other. The amide moiety and the cyclohexane ring are almost perpendicular to each other; a similar conformation was previously observed in reported structures. In the crystal, molecules are linked by N—H...S hydrogen bonds, forming inversion dimers with an R 2 2(8) ring motif.

Microstructure and crystal symmetry of Pb2Sr2(Y/Ca)Cu3O9−δ

1990 ◽  
Vol 48 (4) ◽  
pp. 64-65
Author(s):  
Y. P. Lin ◽  
J. S. Xue ◽  
J. E. Greedan
Keyword(s):  
Electron Diffraction ◽  
High Temperature Superconductors ◽  
Carbon Film ◽  
Basic Structure ◽  
Crystal Symmetry ◽  
X Ray Diffraction ◽  
X Ray ◽  
Space Groups ◽  
New Family ◽  
Convergent Beam

A new family of high temperature superconductors based on Pb2Sr2YCu3O9−δ has recently been reported. One method of improving Tc has been to replace Y partially with Ca. Although the basic structure of this type of superconductors is known, the detailed structure is still unclear, and various space groups has been proposed. In our work, crystals of Pb2Sr2YCu3O9−δ with dimensions up to 1 × 1 × 0.25.mm and with Tc of 84 K have been grown and their superconducting properties described. The defects and crystal symmetry have been investigated using electron microscopy performed on crushed crystals supported on a holey carbon film.Electron diffraction confirmed x-ray diffraction results which showed that the crystals are primitive orthorhombic with a=0.5383, b=0.5423 and c=1.5765 nm. Convergent Beam Electron Diffraction (CBED) patterns for the and axes are shown in Figs. 1 and 2 respectively.

A new family of fluorescent calcium indicators designed to resist leakage or for measuring calcium near membranes

1994 ◽  
Vol 52 ◽  
pp. 168-169
Author(s):  
Martin Poenie ◽  
Akwasi Minta ◽  
Charles Vorndran
Keyword(s):  
Metal Binding ◽  
Acetoxymethyl Ester ◽  
Binding Properties ◽  
Fura 2 ◽  
New Family ◽  
Anion Transporter ◽  
Calcium Indicator ◽  
Calcium Indicators ◽  
High Calcium ◽  
Intracellular Compartmentalization

The use of fura-2 as an intracellular calcium indicator is complicated by problems of rapid dye leakage and intracellular compartmentalization which is due to a probenecid sensitive anion transporter. In addition there is increasing evidence for localized microdomains of high calcium signals which may not be faithfully reported by fura-2.We have developed a new family of fura-2 analogs aimed at addressing some of these problems. These new indicators are based on a modified bapta which can be readily derivatized to produce fura-2 analogs with a variety of new properties. The modifications do not affect the chromophore and have little impact on the spectral and metal binding properties of the indicator. One of these new derivatives known as FPE3 is a zwitterionic analog of fura-2 that can be loaded into cells as an acetoxymethyl ester and whose retention in cells is much improved. The improved retention of FPE3 is important for both cuvettebased measurements of cell suspensions and for calcium imaging.

Scanning tunneling microscopy and atomic force microscopy: New tools for biology

1989 ◽  
Vol 47 ◽  
pp. 778-779
Author(s):  
CE Bracker ◽  
P. K. Hansma
Keyword(s):  
Physical Property ◽  
Scanning Probe ◽  
Scanning Tunneling ◽  
Small Scale ◽  
Tunneling Microscopy ◽  
Force Microscopy ◽  
New Family ◽  
Small Probe ◽  
Atomic Force ◽  
Transmission Electron

A new family of scanning probe microscopes has emerged that is opening new horizons for investigating the fine structure of matter. The earliest and best known of these instruments is the scanning tunneling microscope (STM). First published in 1982, the STM earned the 1986 Nobel Prize in Physics for two of its inventors, G. Binnig and H. Rohrer. They shared the prize with E. Ruska for his work that had led to the development of the transmission electron microscope half a century earlier. It seems appropriate that the award embodied this particular blend of the old and the new because it demonstrated to the world a long overdue respect for the enormous contributions electron microscopy has made to the understanding of matter, and at the same time it signalled the dawn of a new age in microscopy. What we are seeing is a revolution in microscopy and a redefinition of the concept of a microscope.Several kinds of scanning probe microscopes now exist, and the number is increasing. What they share in common is a small probe that is scanned over the surface of a specimen and measures a physical property on a very small scale, at or near the surface. Scanning probes can measure temperature, magnetic fields, tunneling currents, voltage, force, and ion currents, among others.

Porphyrin-functionalized coordination star polymers and their potential applications in photodynamic therapy

2019 ◽  
Vol 10 (45) ◽  
pp. 6116-6121 ◽  
Author(s):  
Tan Ji ◽  
Lei Xia ◽  
Wei Zheng ◽  
Guang-Qiang Yin ◽  
Tao Yue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Star Polymers ◽  
New Family ◽  
Potential Applications

We present a new family of porphyrin-functionalized coordination star polymers prepared through combination of coordination-driven self-assembly and post-assembly polymerization. Their self-assembly behaviour in water and potential for photodynamic therapy were demonstrated.

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