scholarly journals Injectable drug-loaded polysaccharide hybrid hydrogels for hemostasis

RSC Advances ◽  
2019 ◽  
Vol 9 (63) ◽  
pp. 36858-36866 ◽  
Author(s):  
Jinying Cao ◽  
Ling Xiao ◽  
Xiaowen Shi
Keyword(s):  
Blood Loss ◽  
Antibacterial Properties ◽  
Injectable Drug ◽  
Hybrid Hydrogels

A levofloxacin loaded CMC-GEL/OSA hydrogel was synthesized that exhibited good antibacterial properties, 84.2% shortened hemostatic time and 82.2% reduced blood loss.

Swelling and Antibacterial Properties of Chitosan/Poly(vinyl alcohol) Hybrid Hydrogels

2014 ◽  
Vol 672-674 ◽  
pp. 737-740 ◽  
Author(s):  
Jing Jing Zheng ◽  
Xiao Liang Gui
Keyword(s):  
Vinyl Alcohol ◽  
Antibacterial Properties ◽  
Poly Vinyl Alcohol ◽  
Swelling Properties ◽  
Hybrid Hydrogels ◽  
Antimicrobial Performance ◽  
Pva Hydrogel ◽  
Better Than

Chitosan (CTS) was added into poly (vinyl alcohol) (PVA) hydrogels to get their antibacterial properties. A series of CTS/PVA hybrid hydrogels were prepared by freezing/thawing method. The swelling properties of all hybrid hydrogels are better than those of the original PVA hydrogel. The CTS/PVA hybrid hydrogels show excellent antimicrobial performance towards Escherichia colis.

Parto-analgesia and post-partum blood loss

2011 ◽  
Vol 215 (S 01) ◽  
Author(s):  
L Driul ◽  
AP Londero ◽  
V Burra ◽  
T Dogareschi ◽  
A Biasioli ◽  
...  
Keyword(s):  
Blood Loss ◽  
Post Partum

Enhanced Effective Fibrinolysis following the Neutralization of Heparin in Open Heart Surgery Increases the Risk of Post-Surgical Bleeding

1990 ◽  
Vol 63 (02) ◽  
pp. 241-245 ◽  
Author(s):  
Jørgen Gram ◽  
Thomas Janetzko ◽  
Jørgen Jespersen ◽  
Hans Dietrich Bruhn
Keyword(s):  
Blood Loss ◽  
Plasminogen Activator ◽  
Heart Surgery ◽  
Degradation Products ◽  
Open Heart Surgery ◽  
Tissue Type ◽  
Tissue Type Plasminogen Activator ◽  
Type Plasminogen Activator ◽  
Chest Tube Drain ◽  
Median Blood Loss

SummaryThe tissue-type plasminogen activator related fibrinolytic system was studied in 24 patients undergoing cardiopulmonary bypass surgery. The degradation of fibrinogen and fibrin was followed during and after surgery by means of new sensitive and specific assays and the changes were related to the blood loss measured in the chest tube drain during the first 24 postoperative hours. Although tissue-type plasminogen activator was significantly released into the circulation during the period of extracor-poreal circulation (p <0.01), constantly low levels of fibrinogen degradation products indicated that a systemic generation of plasmin could be controlled by the naturally occurring inhibitors. Following extracorporeal circulation heparin was neutralized by protamine chloride, and in relation to the subsequent generation of fibrin, there was a short period with increased concentrations of fibrinogen degradation products (p <0.01) and a prolonged period of degradation of cross-linked fibrin, as detected by increased concentrations of D-Dimer until 24 h after surgery (p <0.01). Patients with a higher than the median blood loss (520 ml) in the chest tube drain had a significantly higher increase of D-Dimer than patients with a lower than the median blood loss (p <0.05).We conclude that the incorporation of tissue-type plasminogen activator into fibrin and the in situ activation of plasminogen enhance local fibrinolysis, thereby increasing the risk of bleeding in patients undergoing open heart surgery

The Effect of Desmopressin on Reducing Blood Loss in Cardiac Surgery – A Meta-Analysis of Double-Blind, Placebo-Controlled Trials

1995 ◽  
Vol 74 (04) ◽  
pp. 1064-1070 ◽  
Author(s):  
Marco Cattaneo ◽  
Alan S Harris ◽  
Ulf Strömberg ◽  
Pier Mannuccio Mannucci
Keyword(s):  
Cardiac Surgery ◽  
Blood Loss ◽  
Meta Analysis ◽  
Postoperative Blood Loss ◽  
Controlled Trials ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Transfusion Requirements ◽  
The Mean ◽  
Excessive Blood Loss

SummaryThe effect of desmopressin (DDAVP) on reducing postoperative blood loss after cardiac surgery has been studied in several randomized clinical trials, with conflicting outcomes. Since most trials had insufficient statistical power to detect true differences in blood loss, we performed a meta-analysis of data from relevant studies. Seventeen randomized, double-blind, placebo-controlled trials were analyzed, which included 1171 patients undergoing cardiac surgery for various indications; 579 of them were treated with desmopressin and 592 with placebo. Efficacy parameters were blood loss volumes and transfusion requirements. Desmopressin significantly reduced postoperative blood loss by 9%, but had no statistically significant effect on transfusion requirements. A subanalysis revealed that desmopressin had no protective effects in trials in which the mean blood loss in placebo-treated patients fell in the lower and middle thirds of distribution of blood losses (687-1108 ml/24 h). In contrast, in trials in which the mean blood loss in placebo-treated patients fell in the upper third of distribution (>1109 ml/24 h), desmopressin significantly decreased postoperative blood loss by 34%. Insufficient data were available to perform a sub-analysis on transfusion requirements. Therefore, desmopressin significantly reduces blood loss only in cardiac operations which induce excessive blood loss. Further studies are called to validate the results of this meta-analysis and to identify predictors of excessive blood loss after cardiac surgery.

The impact of prepartum factor XIII activity on postpartum blood loss

2019 ◽  
Author(s):  
C Haslinger ◽  
W Korte ◽  
T Hothorn ◽  
R Brun ◽  
C Greenberg ◽  
...  
Keyword(s):  
Blood Loss ◽  
Factor Xiii ◽  
Postpartum Blood Loss ◽  
The Impact

Menstruation Among Adolescent Girls Living in Rural Border Areas

2020 ◽  
Vol 4 (8) ◽  
Author(s):  
Ritu Gupta ◽  
Ravinder K Gupta ◽  
Vallabh Dogra ◽  
Himani Badyal
Keyword(s):  
Abdominal Pain ◽  
Menstrual Cycle ◽  
Blood Loss ◽  
Prospective Study ◽  
Adolescent Girls ◽  
Common Side Effect ◽  
Age Group ◽  
Different Types ◽  
Study Population ◽  
Border Areas

Objective: To study the various beliefs and problems regarding menstruation among adolescent girls living in rural border areas. Design- Prospective study. Setting- Pediatric outpatient clinic. Materials and methods- About 200 adolescent girls (11-19 years) living in rural border areas were enrolled for the study. These girls were asked about menarche, duration of the cycle, amount of blood loss and the various menstrual problems. They were also asked about the various beliefs and myths regarding menstruation. The girls having any illness affecting the menstrual cycle or those suffering from neuropsychiatric disorders were excluded from this study. Results- About 51% of the study population was in the age group 17-18 years. About 43.5% of girls attained menarche at the age of 10-12 years. About 51% of girls did not know about menstruation before menarche. Abdominal pain was the most common side effect seen in 41% of girls during menstruation. About 61% of girls considered themselves unclean during menstruation.  Twenty percent avoided schools, 20% avoided kitchen, 12% avoided temples while 10% stayed away from friends/ relatives. Only 33% of girls knew that menstruation stops temporarily after becoming pregnant. Twenty-two percent girls were using sanitary napkins while the rest used different types of clothes during the menstrual cycle. Conclusion- There is a dire need to educate girls regarding menstruation before menarche in the rural border areas. Every mother should discuss in a friendly way regarding various aspects of menstruation.

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