scholarly journals Novel one pot synthesis and spectroscopic characterization of a folate-Mn3O4 nanohybrid for potential photodynamic therapeutic application

RSC Advances ◽  
2019 ◽  
Vol 9 (52) ◽  
pp. 30216-30225 ◽  
Author(s):  
Susmita Mondal ◽  
Aniruddha Adhikari ◽  
Monojit Das ◽  
Soumendra Darbar ◽  
Ahmed Alharbi ◽  
...  
Keyword(s):  
Free Radical ◽  
Cancer Cells ◽  
Folate Receptor ◽  
Spectroscopic Characterization ◽  
Therapeutic Application ◽  
One Pot ◽  
Free Radical Damage ◽  
One Pot Synthesis ◽  
Radical Damage

Folate capped Mn3O4 nanoparticles can be used in PDT for specifically destroying folate receptor-overexpressing cancer cells through photo induced free radical damage.

scholarly journals Facile One-Pot Synthesis of Self-Assembled Folate-Biotin-Pullulan Nanoparticles for Targeted Intracellular Anticancer Drug Delivery

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Ming Wang ◽  
Meiling Huang ◽  
Jianting Wang ◽  
Mingquan Ye ◽  
Yan Deng ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Anticancer Drug ◽  
Folate Receptor ◽  
Flow Cytometric Analysis ◽  
Laser Scanning Microscopy ◽  
The Self ◽  
Kb Cells ◽  
One Pot ◽  
One Pot Synthesis ◽  
Self Assembled

The self-assembled folate-biotin-pullulan (FBP) nanoparticles (NPs) were prepared by facile one-pot synthesis and their physicochemical properties were characterized. The self-assembled FBP NPs were used as an anticancer drug nanocarrier entrapping doxorubicin (DOX) for targeting folate-receptors-overexpressing cancer cells. The identification of prepared NPs to folate-receptor-expressing cancer cells (KB cells) was affirmed by cell viability measurement, folate competition test, and flow cytometric analysis. Compared with the naked DOX and DOX/BP NPs, the DOX/FBP NPs had lower IC50value compared to KB cells as a result of the folate-receptor-mediated endocytosis process. The cytotoxicity of DOX/FBP NPs to KB cells could be inhibited competitively by free folate. The cellular intake pattern of naked DOX and drug-loaded NPs was identified by confocal laser scanning microscopy (CLSM) observation and the higher cellular uptake of drug for DOX/FBP NPs over naked DOX was observed. The prepared FBP NPs had the potential to be used as a powerful carrier to target anticancer drugs to folate-receptor-expressing tumor cells and reduce cytotoxicity to normal tissues.

Study of antioxidant potential in leaves, stems, nuts of Juglans regia L.

2012 ◽  
Vol 1 (10) ◽  
pp. 79 ◽  
Author(s):  
G. Raja* ◽  
Ivvala Anand Shaker ◽  
Inampudi Sailaja ◽  
R. Swaminathan ◽  
S. Saleem Basha ◽  
...  
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Juglans Regia ◽  
Radical Scavenging ◽  
Antioxidant Compounds ◽  
Free Radical Damage ◽  
Radical Damage

Natural antioxidants can protect the human body from free radicals and retard the progress of many chronic diseases as well as lipid oxidative rancidity in foods. The role of antioxidants has protected effect against free radical damage that may cause many diseases including cancer. Primary sources of naturally occurring antioxidants are known as whole grains, fruits, and vegetables. Several studies suggest that regular consumption of nuts, mostly walnuts, may have beneficial effects against oxidative stress mediated diseases such as cardiovascular disease and cancer. The role of antioxidants has attracted much interest with respect to their protective effect against free radical damage that may cause many diseases including cancer. Juglans regia L. (walnut) contains antioxidant compounds, which are thought to contribute to their biological properties. Polyphenols, flavonoids and flavonols concentrations and antioxidant activity of Leaves, Stems and Nuts extract of Juglans regia L. as evaluated using DPPH, ABTS, Nitric acid, hydroxyl and superoxide radical scavenging activity, lipid peroxidation and total oxidation activity were determined. The antioxidant activities of Leaves, Stems and Nuts extract of Juglans regia L. were concentration dependent in different experimental models and it was observed that free radicals were scavenged by the test compounds in all the models.

Cyclical estrogen and free radical damage to the rabbit urinary bladder

2009 ◽  
Vol 21 (4) ◽  
pp. 489-494 ◽  
Author(s):  
Alexandra Rehfuss ◽  
Catherine Schuler ◽  
Christina Maxemous ◽  
Robert E. Leggett ◽  
Robert M. Levin
Keyword(s):  
Free Radical ◽  
Urinary Bladder ◽  
Free Radical Damage ◽  
Radical Damage ◽  
Rabbit Urinary Bladder
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