scholarly journals Theranostic system for ratiometric fluorescence monitoring of peptide-guided targeted drug delivery

RSC Advances ◽  
2019 ◽  
Vol 9 (56) ◽  
pp. 32656-32664 ◽  
Author(s):  
Alex Rozovsky ◽  
T. M. Ebaston ◽  
Alisa Zaporozhets ◽  
Andrii Bazylevich ◽  
Helena Tuchinsky ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer Cell ◽  
Pancreatic Cancer Cell Line ◽  
Cancer Cell Line ◽  
Cancer Targeting ◽  
Ratiometric Fluorescence ◽  
Long Wavelength ◽  
Anticancer Drug Delivery ◽  
Targeting Peptide ◽  
Line P

Novel theranostic system that first combines a cancer-targeting peptide with a long-wavelength dual fluorescent dye IRD in order to provide ratiometric monitoring of anticancer drug delivery is developed and evaluated in pancreatic cancer cell line.

scholarly journals Organometallic nucleoside analogues: effect of the metallocene metal atom on cancer cell line toxicity

2020 ◽  
Vol 49 (4) ◽  
pp. 1181-1190 ◽  
Author(s):  
Media K. Ismail ◽  
Katie A. Armstrong ◽  
Samantha L. Hodder ◽  
Sarah L. Horswell ◽  
Louise Male ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Metal Atom ◽  
Pancreatic Cancer Cell ◽  
Pancreatic Cancer Cell Line ◽  
Cancer Cell Line ◽  
Nucleoside Analogues ◽  
Fold Reduction ◽  
Line P

Changing the metal atom within a metallocene nucleoside analogue from iron to ruthenium results in a five-fold reduction in biological activity in a pancreatic cancer cell line.

scholarly journals Hierarchically designed hybrid nanoparticles for combinational photochemotherapy against a pancreatic cancer cell line

2018 ◽  
Vol 6 (7) ◽  
pp. 1095-1104 ◽  
Author(s):  
F. Joubert ◽  
G. Pasparakis
Keyword(s):  
Pancreatic Cancer ◽  
Gold Nanoparticles ◽  
Cell Line ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Pancreatic Cancer Cell Line ◽  
Cancer Cell Line ◽  
Hybrid Nanoparticles ◽  
Polymer Conjugate ◽  
Line P

Hierarchical formulation of hybrid nanoparticles that consist of aggregated gold nanoparticles impregnated into a gemcitabine–polymer conjugate matrix for photochemotherapy of pancreatic cancer.

scholarly journals Targeted Dendrimer-Coated Magnetic Nanoparticles for Selective Delivery of Therapeutics in Living Cells

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2252
Author(s):  
Paola Parlanti ◽  
Adriano Boni ◽  
Giovanni Signore ◽  
Melissa Santi
Keyword(s):  
Cancer Cells ◽  
Pancreatic Cancer Cell ◽  
Pancreatic Cancer Cell Line ◽  
Cancer Cell Line ◽  
Metal Core ◽  
Dual Nature ◽  
Selective Delivery ◽  
Targeting Peptide ◽  
Theranostic Agents ◽  
The Magnetic Field

Nanoparticles are widely used as theranostic agents for the treatment of various pathologies, including cancer. Among all, dendrimers-based nanoparticles represent a valid approach for drugs delivery, thanks to their controllable size and surface properties. Indeed, dendrimers can be easily loaded with different payloads and functionalized with targeting agents. Moreover, they can be used in combination with other materials such as metal nanoparticles for combinatorial therapies. Here, we present the formulation of an innovative nanostructured hybrid system composed by a metallic core and a dendrimers-based coating that is able to deliver doxorubicin specifically to cancer cells through a targeting agent. Its dual nature allows us to transport nanoparticles to our site of interest through the magnetic field and specifically increase internalization by exploiting the T7 targeting peptide. Our system can release the drug in a controlled pH-dependent way, causing more than 50% of cell death in a pancreatic cancer cell line. Finally, we show how the system was internalized inside cancer cells, highlighting a peculiar disassembly of the nanostructure at the cell surface. Indeed, only the dendrimeric portion is internalized, while the metal core remains outside. Thanks to these features, our nanosystem can be exploited for a multistage magnetic vector.

Ligation of fas antigen stimulates chemoline secretion in pancreatic cancer cell line PANC-1

2001 ◽  
Vol 120 (5) ◽  
pp. A336-A336
Author(s):  
M SHIMADA ◽  
A ANDOH ◽  
Y ARAKI ◽  
Y FUJIYAMA ◽  
T BAMBA
Keyword(s):  
Pancreatic Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Pancreatic Cancer Cell Line ◽  
Cancer Cell Line ◽  
Fas Antigen

scholarly journals Forkhead box B2 inhibits the malignant characteristics of the pancreatic cancer cell line Panc‐1 in vitro

2019 ◽  
Vol 24 (10) ◽  
pp. 674-681
Author(s):  
Hiroki Fukuchi ◽  
Yukinobu Hayashida ◽  
Kunio Inoue ◽  
Yoshifusa Sadamura
Keyword(s):  
Pancreatic Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Pancreatic Cancer Cell Line ◽  
Cancer Cell Line ◽  
Forkhead Box

M1758 Naturally Occurring K Vitamins Inhibit Pancreatic Cancer Cell Line Growth

2009 ◽  
Vol 136 (5) ◽  
pp. A-906
Author(s):  
Shayna L. Showalter ◽  
Ziqiu Wang ◽  
Christina L. Costantino ◽  
Agnes Witkiewicz ◽  
Charles J. Yeo ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Pancreatic Cancer Cell Line ◽  
Cancer Cell Line ◽  
Naturally Occurring
Sign in / Sign up

Export Citation Format

Share Document