scholarly journals Formation and dissociation of synthetic hetero-double-helix complex in aqueous solutions: significant effect of water content on dynamics of structural change

RSC Advances ◽  
2019 ◽  
Vol 9 (50) ◽  
pp. 29456-29462
Author(s):  
Tsukasa Sawato ◽  
Ryosuke Yuzawa ◽  
Higashi Kobayashi ◽  
Nozomi Saito ◽  
Masahiko Yamaguchi

Significant structural changes by small change in water content from 30 to 33%.

1994 ◽  
Vol 27 (3) ◽  
pp. 279-283 ◽  
Author(s):  
Daisuke Itabashi ◽  
Kazumasa Sugiyama ◽  
Eiki Kasai ◽  
Fumio Saito

1982 ◽  
Vol 43 (C9) ◽  
pp. C9-455-C9-458 ◽  
Author(s):  
M. Takata ◽  
M. Tomozawa ◽  
J. Acocella ◽  
J. Molinelli ◽  
C. Y. Erwin ◽  
...  

2019 ◽  
Vol 26 (6) ◽  
pp. 449-457
Author(s):  
Ting Song ◽  
Keke Cao ◽  
Yu dan Fan ◽  
Zhichao Zhang ◽  
Zong W. Guo ◽  
...  

Background: The significance of multi-site phosphorylation of BCL-2 protein in the flexible loop domain remains controversial, in part due to the lack of structural biology studies of phosphorylated BCL-2. Objective: The purpose of the study is to explore the phosphorylation induced structural changes of BCL-2 protein. Methods: We constructed a phosphomietic mutant BCL-2(62-206) (t69e, s70e and s87e) (EEEBCL- 2-EK (62-206)), in which the BH4 domain and the part of loop region was truncated (residues 2-61) to enable a backbone resonance assignment. The phosphorylation-induced structural change was visualized by overlapping a well dispersed 15N-1H heteronuclear single quantum coherence (HSQC) NMR spectroscopy between EEE-BCL-2-EK (62-206) and BCL-2. Results: The EEE-BCL-2-EK (62-206) protein reproduced the biochemical and cellular activity of the native phosphorylated BCL-2 (pBCL-2), which was distinct from non-phosphorylated BCL-2 (npBCL-2) protein. Some residues in BH3 binding groove occurred chemical shift in the EEEBCL- 2-EK (62-206) spectrum, indicating that the phosphorylation in the loop region induces a structural change of active site. Conclusion: The phosphorylation of BCL-2 induced structural change in BH3 binding groove.


2020 ◽  
Vol 263 ◽  
pp. 120107
Author(s):  
Romain Damez ◽  
Philippe Artillan ◽  
Arthur Hellouin de Menibus ◽  
Cédric Bermond ◽  
Pascal Xavier

1986 ◽  
Vol 18 (9) ◽  
pp. 1189-1207
Author(s):  
B Ó Huallacháin

The conventional approach to assessing structural change in regional input – output tables is to measure the impact of coefficient change on the estimation of outputs and multipliers. The methods developed and tested in this paper focus exclusively on the coefficients. Univariate and multivariate statistical analyses can be used to identify and measure various types of changes ranging from coefficient instability to changes in interindustry relationships as a system. A distinction is made between structural changes in input relationships and those in output relationships. The methods are tested by using Washington State data for the years 1963 and 1967. The results are compared with previous analyses of change in these data.


Langmuir ◽  
2004 ◽  
Vol 20 (7) ◽  
pp. 2883-2889 ◽  
Author(s):  
Claudia Querner ◽  
Thomas Schmidt ◽  
Karl-Friedrich Arndt

2021 ◽  
Vol 15 (4) ◽  
pp. 1-22
Author(s):  
Huan Wang ◽  
Chunming Qiao ◽  
Xuan Guo ◽  
Lei Fang ◽  
Ying Sha ◽  
...  

Recently, dynamic social network research has attracted a great amount of attention, especially in the area of anomaly analysis that analyzes the anomalous change in the evolution of dynamic social networks. However, most of the current research focused on anomaly analysis of the macro representation of dynamic social networks and failed to analyze the nodes that have anomalous structural changes at a micro level. To identify and evaluate anomalous structural change-based nodes in generalized dynamic social networks that only have limited structural information, this research considers undirected and unweighted graphs and develops a multiple-neighbor superposition similarity method ( ), which mainly consists of a multiple-neighbor range algorithm ( ) and a superposition similarity fluctuation algorithm ( ). introduces observation nodes, characterizes the structural similarities of nodes within multiple-neighbor ranges, and proposes a new multiple-neighbor similarity index on the basis of extensional similarity indices. Subsequently, maximally reflects the structural change of each node, using a new superposition similarity fluctuation index from the perspective of diverse multiple-neighbor similarities. As a result, based on and , not only identifies anomalous structural change-based nodes by detecting the anomalous structural changes of nodes but also evaluates their anomalous degrees by quantifying these changes. Results obtained by comparing with state-of-the-art methods via extensive experiments show that can accurately identify anomalous structural change-based nodes and evaluate their anomalous degrees well.


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