scholarly journals A multicomponent, facile and catalyst-free microwave-assisted protocol for the synthesis of pyrazolo-[3,4-b]-quinolines under green conditions

RSC Advances ◽  
2019 ◽  
Vol 9 (53) ◽  
pp. 30768-30772 ◽  
Author(s):  
Mandlenkosi Robert Khumalo ◽  
Surya Narayana Maddila ◽  
Suresh Maddila ◽  
Sreekantha B. Jonnalagadda
Keyword(s):  
Ambient Temperature ◽  
Aqueous Ethanol ◽  
Reaction Medium ◽  
One Pot ◽  
Microwave Assisted ◽  
Catalyst Free ◽  
Green Conditions

A facile, swift and ecofriendly microwave-assisted multi-component/one-pot protocol is designed for the synthesis of novel pyrazolo-[3,4-b]-quinolines at ambient temperature in aqueous ethanol as a reaction medium.

An Expeditious One-Pot Three-Component Synthesis of 4-Aryl-3,4-dihydrobenzo[g] quinoline-2,5,10(1H)-triones under Green Conditions

2020 ◽  
Vol 23 (23) ◽  
pp. 2626-2634
Author(s):  
Saiedeh Kamalifar ◽  
Hamzeh Kiyani
Keyword(s):  
Reaction Medium ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
One Pot Synthesis ◽  
Substituted Benzaldehydes ◽  
High Yields ◽  
First Time ◽  
Green Conditions

: An efficient and facial one-pot synthesis of 4-aryl-3,4-dihydrobenzo[g]quinoline- 2,5,10(1H)-triones was developed for the first time. The process proceeded via the three-component cyclocondensation of 2-amino-1,4-naphthoquinone with Meldrum’s acid and substituted benzaldehydes under green conditions. The fused 3,4-dihydropyridin-2(1H)- one-ring naphthoquinones have been synthesized with good to high yields in refluxing ethanol as a green reaction medium. This protocol is simple and effective as well as does not involve the assistance of the catalyst, additive, or hazardous solvents.

Catalyst-free, one-pot, four-component green synthesis of functionalized 1-(2-fluorophenyl)-1,4-dihydropyridines under ultrasound irradiation

2016 ◽  
Vol 40 (6) ◽  
pp. 5107-5112 ◽  
Author(s):  
Nhlanhla Shabalala ◽  
Suresh Maddila ◽  
Sreekantha B. Jonnalagadda
Keyword(s):  
Green Synthesis ◽  
Ultrasonic Irradiation ◽  
Aqueous Ethanol ◽  
Ultrasound Irradiation ◽  
One Pot ◽  
Catalyst Free ◽  
New Compounds ◽  
Synthesis Protocol

A catalyst-free synthesis protocol for functionalized 1,4-dihydropyridines under ultrasonic irradiation in aqueous ethanol is reported with excellent yields. Eleven new compounds are synthesized using dimethylacetylenedicarboxylate, 2-fluoroaniline, malononitrile and various substituted aldehydes.

Glycerol: A Promising Benign Solvent for Catalyst Free One-Pot Multi-Component Synthesis of Pyrano[2,3-c]pyrazoles and Tetrahydro-benzo[b]pyrans at Ambient Temperature

2017 ◽  
Vol 2 (33) ◽  
pp. 10689-10693 ◽  
Author(s):  
Afaf Abdel Hamid ◽  
Mohamed Abd-Elmonem ◽  
Alaa M. Hayallah ◽  
Fatma A. Abo Elsoud ◽  
Kamal U. Sadek
Keyword(s):  
Ambient Temperature ◽  
One Pot ◽  
Catalyst Free

Microwave-assisted Efficient One-pot Synthesis of Nitriles Using Recyclable Magnetite (Fe3O4) Nanoparticles as Catalyst and Water as Solvent: A Greener Approach

2020 ◽  
Vol 10 (4) ◽  
pp. 507-517
Author(s):  
Prashant Chavan ◽  
Suhas Pednekar ◽  
Ramesh Chaughule ◽  
Anushree Lokur
Keyword(s):  
Fe3o4 Nanoparticles ◽  
Reaction Medium ◽  
Chemical Yield ◽  
Significant Loss ◽  
Microwave Assisted Synthesis ◽  
Microwave Activation ◽  
One Pot ◽  
Microwave Assisted ◽  
Magnetite Fe3o4 ◽  
Water As Solvent

Background: There has been an increasing curiosity over the past few years to carry out organic reactions over heterogeneous nanocatalysts. Microwave activation coupled with a nanocatalyst along with water as a reaction medium makes the process further green. Microwave activation as a green process reduces reaction times, enhances product purity and improves chemical yield. Methods: Nitrile group chemistry has been explored by many researchers across the globe owing to its interesting properties and its importance in synthetic chemistry. Despite several methods being available for the synthesis of nitriles, microwave assisted synthesis of nitriles using Fe3O4 nanoparticles appears more promising. The present study is intended at developing a recyclable magnetite (Fe3O4) nanoparticles catalyzed protocol towards the synthesis of organonitrile derivatives using one pot reaction. Results: The above protocol incorporates the use of microwave for heating and water as reaction medium. Several substituted nitriles could be synthesized for excellent yields. The magnetite nanoparticles can be reused for new reaction without significant loss in activity. Conclusion: The experiment makes the protocol simple, environment friendly and economically feasible.

Green catalyst-free one-pot synthesis of novel tetrahydropyridine-3-carboxamides by microwave-assisted approach

2020 ◽  
Vol 132 (1) ◽  
Author(s):  
Mandlenkosi Khumalo ◽  
Surya Narayana Maddila ◽  
Suresh Maddila ◽  
Sreekantha B Jonnalagadda
Keyword(s):  
One Pot ◽  
Green Catalyst ◽  
Microwave Assisted ◽  
Catalyst Free ◽  
One Pot Synthesis

Microwave-Assisted, Solvent-Free, Three-Component Synthesis of 2,4,6-Triarylpyridines from Benign Components

2012 ◽  
Vol 36 (3) ◽  
pp. 138-140 ◽  
Author(s):  
Shahab Zomordbakhsh ◽  
Hossein Anaraki-Ardakani ◽  
Mohsen Zeeb ◽  
Mahdi Sadeghi ◽  
Manouchehr Mazraeh-Seffid
Keyword(s):  
Solvent Free ◽  
One Pot ◽  
Microwave Assisted ◽  
Green Conditions

2,4,6-Triarylpyridine derivatives were synthesised by the reaction of guanidine with an acetophenone and a chalcone. These reactions were carried out as economical one-pot reactions under green conditions: no catalyst and solvent free.

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