scholarly journals Cell adherence and drug delivery from particle based mesoporous silica films

RSC Advances ◽  
2019 ◽  
Vol 9 (31) ◽  
pp. 17745-17753
Author(s):  
Emma M. Björk ◽  
Bernhard Baumann ◽  
Florian Hausladen ◽  
Rainer Wittig ◽  
Mika Lindén
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cell Adherence ◽  
Silica Films ◽  
System P ◽  
Growth Method ◽  
Direct Growth

Particle-based mesoporous silica films synthesized through a direct growth method were successfully used as a drug delivery system.

A bio-inspired fluorescent nano-injectable hydrogel as a synergistic drug delivery system

2021 ◽  
Vol 45 (6) ◽  
pp. 3079-3087
Author(s):  
Yue Xu ◽  
Mingming Yang ◽  
Qiyue Ma ◽  
Xiang Di ◽  
Guolin Wu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Fluorescence Properties ◽  
Injectable Hydrogel ◽  
Sequential Release ◽  
System P

A nano-injectable hydrogel with fluorescence properties and controlled sequential release of dual drugs.

scholarly journals pH-responsive mesoporous silica drug delivery system, its biocompatibility and co-adsorption/co-release of 5-Fluorouracil and Naproxen

2021 ◽  
pp. 150011
Author(s):  
Eva Benova ◽  
Virginie Hornebecq ◽  
Vladimír Zelenak ◽  
Veronika Huntosova ◽  
Miroslav Almasi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Co Adsorption ◽  
Ph Responsive

Wetting transition in nanochannels for biomimetic free-blocking on-demand drug transport

2018 ◽  
Vol 6 (39) ◽  
pp. 6269-6277 ◽  
Author(s):  
Yaya Cheng ◽  
Xiangyu Jiao ◽  
Liang Zhao ◽  
Yang Liu ◽  
Fang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
Mesoporous Silica Nanoparticles ◽  
Wetting Transition ◽  
On Demand ◽  
Inner Surface

Inspired by aquaporins in nature, herein, a biomimetic free-blocking on-demand drug delivery system is proposed, which is constructed by controlling the wettability of the inner surface of nanochannels on mesoporous silica nanoparticles (MSNs).

scholarly journals ADAM9-Responsive Mesoporous Silica Nanoparticles for Targeted Drug Delivery in Pancreatic Cancer

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3321
Author(s):  
Etienne J. Slapak ◽  
Lily Kong ◽  
Mouad el Mandili ◽  
Rienk Nieuwland ◽  
Alexander Kros ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Conditioned Medium ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Pdac Cell ◽  
Targeted Drug

Pancreatic ductal adenocarcinoma (PDAC) has the worst survival rate of all cancers. This poor prognosis results from the lack of efficient systemic treatment regimens, demanding high-dose chemotherapy that causes severe side effects. To overcome dose-dependent toxicities, we explored the efficacy of targeted drug delivery using a protease-dependent drug-release system. To this end, we developed a PDAC-specific drug delivery system based on mesoporous silica nanoparticles (MSN) functionalized with an avidin–biotin gatekeeper system containing a protease linker that is specifically cleaved by tumor cells. Bioinformatic analysis identified ADAM9 as a PDAC-enriched protease, and PDAC cell-derived conditioned medium efficiently cleaved protease linkers containing ADAM9 substrates. Cleavage was PDAC specific as conditioned medium from leukocytes was unable to cleave the ADAM9 substrate. Protease linker-functionalized MSNs were efficiently capped with avidin, and cap removal was confirmed to occur in the presence of PDAC cell-derived ADAM9. Subsequent treatment of PDAC cells in vitro with paclitaxel-loaded MSNs indeed showed high cytotoxicity, whereas no cell death was observed in white blood cell-derived cell lines, confirming efficacy of the nanoparticle-mediated drug delivery system. Taken together, this research introduces a novel ADAM9-responsive, protease-dependent, drug delivery system for PDAC as a promising tool to reduce the cytotoxicity of systemic chemotherapy.

Design and development of paliperidone mesoporous silica template as a platform for surge dose drug delivery system

2018 ◽  
Vol 34 (3) ◽  
pp. 117-125 ◽  
Author(s):  
Vishal Vijay Pande ◽  
Komal Sadashiv Jadhav ◽  
Mahendra Ashok Giri ◽  
Prakash Namdeo Kendre ◽  
Somanth Kedarling Vibhute ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Design And Development ◽  
Silica Template
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