scholarly journals Novel designed azo substituted semi-cyanine fluorescent probe for cytochrome P450 reductase detection and hypoxia imaging in cancer cells

RSC Advances ◽  
2019 ◽  
Vol 9 (37) ◽  
pp. 21572-21577 ◽  
Author(s):  
Caiyue Wang ◽  
Shuping Zhang ◽  
Junhai Huang ◽  
Lei Cui ◽  
Jin Hu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cancer Cells ◽  
Fluorescent Probe ◽  
Cytochrome P450 Reductase ◽  
Hypoxia Imaging ◽  
P450 Reductase ◽  
Hypoxic Conditions

An NIR hypoxia activated fluorescent probe was designed with fast performance and sensitivity response to hypoxic conditions.

A NIR turn-on fluorescent probe applied in cytochrome P450 reductase detection and hypoxia imaging in tumor cells

2017 ◽  
Vol 139 ◽  
pp. 587-592 ◽  
Author(s):  
Lei Cui ◽  
Yanping Shi ◽  
Shuping Zhang ◽  
Luliang Yan ◽  
Huan Zhang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Tumor Cells ◽  
Fluorescent Probe ◽  
Cytochrome P450 Reductase ◽  
Hypoxia Imaging ◽  
Turn On ◽  
P450 Reductase

scholarly journals KEMTUB012-NI2, a novel potent tubulysin analog that selectively targets hypoxic cancer cells and is potentiated by cytochrome p450 reductase downregulation

Hypoxia ◽  
2017 ◽  
Vol Volume 5 ◽  
pp. 45-59
Author(s):  
Paolo Lazzari ◽  
Marco Spiga ◽  
Monica Sani ◽  
Matteo Zanda ◽  
Ian N Fleming
Keyword(s):  
Cytochrome P450 ◽  
Cancer Cells ◽  
Cytochrome P450 Reductase ◽  
P450 Reductase

Interactions of cytochrome P450 2B4 with NADPH-cytochrome P450 reductase studied by fluorescent probe

Biochimie ◽  
1996 ◽  
Vol 78 (8-9) ◽  
pp. 734-743 ◽  
Author(s):  
D.R. Davydov ◽  
T.V. Knyushko ◽  
I.P. Kanaeva ◽  
Y.M. Koen ◽  
N.F. Samenkova ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Fluorescent Probe ◽  
Cytochrome P450 Reductase ◽  
Nadph Cytochrome ◽  
P450 Reductase ◽  
Cytochrome P450 2B4 ◽  
Nadph Cytochrome P450 Reductase

Fatty Liver and Impaired Hepatic Metabolism Alters the Congener-Specific Distribution of Polychlorinated Biphenyls (PCBs) in Mice with a Liver-Specific Deletion of Cytochrome P450 Reductase

2020 ◽  
Author(s):  
Xueshu Li ◽  
Chun-Yun Zhang ◽  
Hans-Joachim Lehmler
Keyword(s):  
Cytochrome P450 ◽  
Polychlorinated Biphenyls ◽  
Fatty Liver ◽  
Partition Coefficients ◽  
Hepatic Metabolism ◽  
Gas Chromatography Mass Spectrometry ◽  
Cytochrome P450 Reductase ◽  
P450 Reductase ◽  
Specific Distribution ◽  
Specific Deletion

Polychlorinated biphenyls (PCBs) are persistent organic pollutants that are linked to adverse health outcomes. PCB tissue levels are determinants of PCB toxicity; however, it is unclear how factors, such as an altered metabolism and/or a fatty liver, affect PCB distribution in vivo. We determined the congener-specific disposition of PCBs in mice with a liver specific deletion of cytochrome P450 reductase (KO), a model of fatty liver with impaired hepatic metabolism, and wildtype (WT) mice. Male and female KO and WT mice were exposed orally to Aroclor 1254, a technical PCB mixture. PCBs were quantified in adipose, blood, brain and liver tissues by gas chromatography-mass spectrometry. PCB profiles and levels in tissues were genotype and sex dependent. PCB levels were higher in the liver from KO compared to WT mice. PCB profiles showed clear differences between tissues from the same exposure group. While experimental tissue : blood partition coefficients in KO and WT mice did not follow the trends predicted using a composition-based model, the agreement between experimental and calculated partition coefficients was still reasonable. Thus, a fatty liver and/or an impaired hepatic metabolism alter the distribution of PCBs in mice and the magnitude of the partitioning of PCBs from blood into tissues can be approximated using composition-based models.<br>

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