scholarly journals Anti-inflammatory effects of hederagenin on diabetic cardiomyopathy via inhibiting NF-κB and Smads signaling pathways in a type-2 diabetic mice model

RSC Advances ◽  
2019 ◽  
Vol 9 (45) ◽  
pp. 26238-26247
Author(s):  
Ying Li ◽  
Junli Dong ◽  
Yinghui Shang ◽  
Qiangqiang Zhao ◽  
Pengcheng Li ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Signaling Pathways ◽  
Diabetic Cardiomyopathy ◽  
Natural Compound ◽  
Diabetic Mice ◽  
Mice Model ◽  
Pentacyclic Triterpenes ◽  
Anti Inflammatory ◽  
Type 2 Diabetic

Hederagenin (HED) is a bioactive natural compound of pentacyclic triterpenes extracted from many medicinal plants.

Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained

2014 ◽  
Vol 393 (1-2) ◽  
pp. 143-151 ◽  
Author(s):  
Emmelie Cansby ◽  
Annika Nerstedt ◽  
Manoj Amrutkar ◽  
Esther Nuñez Durán ◽  
Ulf Smith ◽  
...  
Keyword(s):  
Diabetic Mice ◽  
Anti Inflammatory ◽  
Type 2 Diabetic ◽  
Inflammatory Effect

scholarly journals Vildagliptin Attenuates Myocardial Dysfunction and Restores Autophagy via miR-21/SPRY1/ERK in Diabetic Mice Heart

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiaochen Li ◽  
Cheng Meng ◽  
Fei Han ◽  
Juhong Yang ◽  
Jingyu Wang ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Diabetic Cardiomyopathy ◽  
High Glucose ◽  
Myocardial Dysfunction ◽  
Mammalian Target Of Rapamycin ◽  
Major Adverse Cardiovascular Events ◽  
H9c2 Cells ◽  
Diabetic Mice ◽  
Type 2 Diabetic

Aim: Vildagliptin (vild) improves diastolic dysfunction and is associated with a lower relative risk of major adverse cardiovascular events in younger patients. The present study aimed to evaluate whether vild prevents the development of diabetic cardiomyopathy in type 2 diabetic mice and identify its underlying mechanisms.Methods: Type 2 diabetic mouse model was generated using wild-type (WT) (C57BL/6J) and miR-21 knockout mice by treatment with HFD/STZ. Cardiomyocyte-specific miR-21 overexpression was achieved using adeno-associated virus 9. Echocardiography was used to evaluate cardiac function in mice. Morphology, autophagy, and proteins levels in related pathway were analyzed. qRT-PCR was used to detect miR-21. Rat cardiac myoblast cell line (H9c2) cells were transfected with miR-21 mimics and inhibitor to explore the related mechanisms of miR-21 in diabetic cardiomyopathy.Results: Vild restored autophagy and alleviated fibrosis, thereby enhancing cardiac function in DM mice. In addition, miR-21 levels were increased under high glucose conditions. miR-21 knockout DM mice with miR-21 knockout had reduced cardiac hypertrophy and cardiac dysfunction compared to WT DM mice. Overexpression of miR-21 aggravated fibrosis, reduced autophagy, and attenuated the protective effect of vild on cardiac function. In high-glucose-treated H9c2 cells, the downstream effectors of sprouty homolog 1 (SPRY1) including extracellular signal-regulated kinases (ERK) and mammalian target of rapamycin showed significant changes following transfection with miR-21 mimics or inhibitor.Conclusion: The results of our study indicate that vild prevents DCM by restoring autophagy through the miR-21/SPRY1/ERK/mTOR pathway. Therefore, miR-21 is a target in the development of DCM, and vild demonstrates significant potential for clinical application in prevention of DCM.

scholarly journals Hypoglycemic effect of Camellia chrysantha extract on type 2 diabetic mice model

2017 ◽  
Vol 12 (4) ◽  
pp. 359
Author(s):  
Lai Wang ◽  
Debmalya Roy ◽  
Sen Sen Lin ◽  
Sheng Tao Yuan ◽  
Li Sun
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Ethyl Acetate ◽  
Glucose Level ◽  
Video Clip ◽  
Hypoglycemic Effect ◽  
Diabetic Mice ◽  
Mice Model ◽  
Type 2 Diabetic

<p class="Abstract">The aim of this study was to investigate the hypoglycemic effect of Camellia chrysantha using type 2 diabetic mice model. The ethyl acetate/dichloromethane extract exhibited the most effective hypoglycemic effect. Compared to model group, all the three groups of C. chrysantha extracts significantly improved the mice’s behavioral performance, weight, reduced water and food intake. The ethyl acetate/dichloromethane extract of C. chrysantha significantly reduced the blood glucose level in the first week after administration and the crude extract also showed a significant effect after longer time administration. All the three extracts reduced the fasting blood glucose level to a certain extent and ethyl acetate/dichloromethane extract exhibited most significant effect among all the three extracts.</p><p><strong>Video Clip of Methodology</strong>:</p><p>1 min 31 sec   <a href="https://www.youtube.com/v/X_H_vaA7MgE">Full Screen</a>   <a href="https://www.youtube.com/watch?v=X_H_vaA7MgE">Alternate</a></p>

Exercise and Stevia Rebaudiana (R) Extracts Attenuate Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms

2020 ◽  
Vol 20 (7) ◽  
pp. 1117-1132
Author(s):  
Abdelaziz M. Hussein ◽  
Elsayed A. Eid ◽  
Ismaeel Bin-Jaliah ◽  
Medhat Taha ◽  
Lashin S. Lashin
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Diabetic Cardiomyopathy ◽  
Caspase 3 ◽  
Stevia Rebaudiana ◽  
Diabetic Rats ◽  
Control Group ◽  
Underlying Mechanisms ◽  
Type 2 Diabetic

Background and Aims: In the current work, we studied the effects of exercise and stevia rebaudiana (R) extracts on diabetic cardiomyopathy (DCM) in type 2 diabetic rats and their possible underlying mechanisms. Methods: : Thirty-two male Sprague Dawley rats were randomly allocated into 4 equal groups; a) normal control group, b) DM group, type 2 diabetic rats received 2 ml oral saline daily for 4 weeks, c) DM+ Exercise, type 2 diabetic rats were treated with exercise for 4 weeks and d) DM+ stevia R extracts: type 2 diabetic rats received methanolic stevia R extracts. By the end of the experiment, serum blood glucose, HOMA-IR, insulin and cardiac enzymes (LDH, CK-MB), cardiac histopathology, oxidative stress markers (MDA, GSH and CAT), myocardial fibrosis by Masson trichrome, the expression of p53, caspase-3, α-SMA and tyrosine hydroxylase (TH) by immunostaining in myocardial tissues were measured. Results: T2DM caused a significant increase in blood glucose, HOMA-IR index, serum CK-MB and LDH, myocardial damage and fibrosis, myocardial MDA, myocardial α-SMA, p53, caspase-3, Nrf2 and TH density with a significant decrease in serum insulin and myocardial GSH and CAT (p< 0.05). On the other hand, treatment with either exercise or stevia R extracts significantly improved all studied parameters (p< 0.05). Moreover, the effects of stevia R was more significant than exercise (p< 0.05). Conclusion: Both exercise and methanolic stevia R extracts showed cardioprotective effects against DCM and Stevia R offered more cardioprotective than exercise. This cardioprotective effect of these lines of treatment might be due to attenuation of oxidative stress, apoptosis, sympathetic nerve density and fibrosis and upregulation of the antioxidant transcription factor, Nrf2.

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