scholarly journals In vivo targeting of breast cancer with a vasculature-specific GQDs/hMSN nanoplatform

RSC Advances ◽  
2019 ◽  
Vol 9 (20) ◽  
pp. 11576-11584 ◽  
Author(s):  
Jingjing Dong ◽  
Xinyue Yao ◽  
Shian Sun ◽  
Yuanyuan Zhong ◽  
Chuntong Qian ◽  
...  

According to our previous experiment, graphene quantum dots capped in hollow mesoporous silica nanoparticles, denoted as GQDs@hMSN, and its conjugates exhibited great potential for medical applications due to their commendable biocompatibility.

2018 ◽  
Author(s):  
Wei Chen ◽  
ChiAn Cheng ◽  
Emily Cosco ◽  
Shyam Ramakrishnan ◽  
Jakob Lingg ◽  
...  

Tissue is translucent to shortwave infrared (SWIR) light, rendering optical imaging superior in this region. However, the widespread use of optical SWIR imaging has been limited, in part, by the lack of bright, biocompatible contrast agents that absorb and emit light above 1000 nm. J-aggregation offers a means to transform stable, near-infrared (NIR) fluorophores into red-shifted SWIR contrast agents. Here we demonstrate that hollow mesoporous silica nanoparticles (HMSNs) can template the J-aggregation of NIR fluorophore IR-140 to result in nanomaterials that absorb and emit SWIR light. The J-aggregates inside PEGylated HMSNs are stable for multiple weeks in buffer and enable high resolution imaging <i>in vivo</i>with 980 nm excitation.


Nanoscale ◽  
2014 ◽  
Vol 6 (12) ◽  
pp. 6617-6626 ◽  
Author(s):  
D. Mahony ◽  
A. S. Cavallaro ◽  
K. T. Mody ◽  
L. Xiong ◽  
T. J. Mahony ◽  
...  

Immunisation studies in mice show that hollow mesoporous silica nanoparticles act as both a delivery vehicle and adjuvant for the viral protein E2 from bovine viral diahorrea virus.


Langmuir ◽  
2016 ◽  
Vol 33 (2) ◽  
pp. 591-599 ◽  
Author(s):  
Xianxian Yao ◽  
Zhengfang Tian ◽  
Jiaxing Liu ◽  
Yufang Zhu ◽  
Nobutaka Hanagata

2017 ◽  
Author(s):  
Juan L. Vivero-Escoto ◽  
Laura Moore Jeffords ◽  
Didier Dréau ◽  
Merlis Alvarez-Berrios ◽  
Pinku Mukherjee

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