scholarly journals Tannic acid-stabilized gold nano-particles are superior to native tannic acid in inducing ROS-dependent mitochondrial apoptosis in colorectal carcinoma cells via the p53/AKT axis

RSC Advances ◽  
2019 ◽  
Vol 9 (14) ◽  
pp. 8025-8038 ◽  
Author(s):  
Sayoni Nag ◽  
Krishnendu Manna ◽  
Krishna Das Saha
Keyword(s):  
Colon Cancer ◽  
Colorectal Carcinoma ◽  
Cancer Cells ◽  
Tannic Acid ◽  
Carcinoma Cells ◽  
Nano Particles ◽  
Akt Pathway ◽  
Mitochondrial Apoptosis ◽  
Colon Cancer Cells ◽  
Gold Nano Particles

Tannic acid and AuNP-TA lead to death of colon cancer cells via the ROS/p53/Akt pathway, and AuNP-TA is more potent.

scholarly journals DJ-1 promotes survival of human colon cancer cells under hypoxia by modulating HIF-1α expression through the PI3K-AKT pathway

2018 ◽  
Vol Volume 10 ◽  
pp. 4615-4629 ◽  
Author(s):  
Hong Zheng ◽  
Chao Zhou ◽  
Xiao Lu ◽  
Quanxing Liu ◽  
Minqiang Liu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Akt Pathway ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells

2008 ◽  
Vol 389 (6) ◽  
Author(s):  
Rebecca S. Henkhaus ◽  
Eugene W. Gerner ◽  
Natalia A. Ignatenko
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Small Interference Rna ◽  
Colon Carcinoma Cells ◽  
Kallikrein 6

Abstract Kallikrein 6 (KLK6) is a trypsin-like serine peptidase whose relevance in various types of cancers is currently being explored. Previous studies have shown that KLK6 mRNA is upregulated in colon and gastric cancers; however, the regulatory mechanisms and phenotypic consequences of this upregulation are largely unknown. Activating K-RAS mutations are common in colon cancer, occurring in approximately 50% of cases. We have recently reported the upregulation of KLK6 mRNA in Caco2 human colon cancer cells stably transfected with a mutant K-RAS allele (K-RASG12V). In this study we examined the pattern of K-RAS-dependent KLK6 expression and secretion in colon cancer cells. Using pharmacological inhibitors of pathways downstream of K-RAS, we could show that the PI3K and p42/44 MAPK pathways play an important role in the induction of KLK6 in mutant K-RAS-expressing colon cancer cells. Increased KLK6 expression enhanced colon cancer cell migration through laminin and Matrigel. Inhibition of KLK6 using small interference RNA treatment or a specific KLK6 antibody in Caco2 cells stably expressing the mutant K-RAS and in SW480 cells carrying a mutation in the K-RAS oncogene resulted in a reduction in invasiveness through cell culture inserts. These data support the oncogenic role of KLK6 in colorectal cancer.

CXCL13-CXCR5 axis promotes the growth and invasion of colon cancer cells via PI3K/AKT pathway

2014 ◽  
Vol 400 (1-2) ◽  
pp. 287-295 ◽  
Author(s):  
Zhenyu Zhu ◽  
Xukui Zhang ◽  
Hongliang Guo ◽  
Ling Fu ◽  
Ganlin Pan ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Akt Pathway ◽  
Colon Cancer Cells
Sign in / Sign up

Export Citation Format

Share Document