Manipulating the helix–coil transition profile of synthetic polypeptides by leveraging side-chain molecular interactions

2020 ◽  
Vol 11 (8) ◽  
pp. 1445-1449 ◽  
Author(s):  
Ziyuan Song ◽  
Zhengzhong Tan ◽  
Xuetao Zheng ◽  
Zihuan Fu ◽  
Ettigounder Ponnusamy ◽  
...  
Keyword(s):  
Molecular Interactions ◽  
Ph Sensitive ◽  
Side Chain ◽  
Coil Transition ◽  
Synthetic Polypeptides ◽  
Transition Profile

Based on the pH-sensitive, conformationally tunable triazole polypeptides, we reported the manipulation of helix–coil transition profile determined by the leveraging interactions of the triazole and other side-chain helix-influencing ligands.

scholarly journals Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces

2015 ◽  
Vol 51 (2) ◽  
pp. 273-275 ◽  
Author(s):  
Joe E. Baio ◽  
Denise Schach ◽  
Adrian V. Fuchs ◽  
Lars Schmüser ◽  
Nils Billecke ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Cell Penetrating Peptides ◽  
Ph Sensitive ◽  
Sensitive Cell ◽  
Gold Surfaces ◽  
Transition Mechanism ◽  
Coil Transition ◽  
Cell Penetrating ◽  
Covalently Bound

Here, we demonstrate that a fusion protein mimic, designed to achieve a reversible, pH-driven helix-coil transition mechanism, retain its functionality when covalently bound to a surface.

Helical Sense and Twisting Power in Thermotropic Side–Chain Copolymers

1990 ◽  
Vol 214 ◽  
Author(s):  
Sushil Krishnamurthy ◽  
Shaw H. Chen
Keyword(s):  
Molecular Interactions ◽  
Structural Similarity ◽  
Side Chain ◽  
Backbone Flexibility ◽  
Phenylethyl Alcohol ◽  
Chiral Nematic ◽  
Helical Twisting Power

ABSTRACTThermotropic chiral nematic copolymers containing (S)–(–)–1–phenylethyl alcohol and (R)–(–)–methyl mandelate with methacrylate backbone and those containing (S)–(–)–1–phenylethylamine and cholesterol with acrylate/methacrylate mixed backbone structures have been synthesized and characterized. It is found that the helical sense is dictated by chiral/nematic molecular interactions of a steric nature, and that the helical twisting power (HTP) is favored by the structural similarity between the chiral and nematic components. Furthermore, it is shown that HTP can be optimized with a suitable nematogenic comonomer by regulating the backbone flexibility within the acrylate/methacrylate series, which facilitates supramolecular arrangement without affecting the HTP.

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