Experimental model design: exploration and optimization of customized polymerization conditions for the preparation of targeted smart materials by the Diels Alder click reaction

2019 ◽  
Vol 10 (40) ◽  
pp. 5473-5486
Author(s):  
Nieves Iglesias ◽  
Elsa Galbis ◽  
Lucía Romero-Azogil ◽  
Elena Benito ◽  
M.-Jesús Díaz-Blanco ◽  
...  
Keyword(s):  
Experimental Model ◽  
Smart Materials ◽  
Biomedical Applications ◽  
Click Reaction ◽  
Diels Alder ◽  
Model Design ◽  
Design Exploration ◽  
Responsive Materials ◽  
Indispensable Tool ◽  
Polymerization Conditions

The experimental model design proposed herein has proved to be an indispensable tool to rapidly and easily elucidate the optimal polymerization conditions in the preparation of tailor-made responsive materials for biomedical applications.

scholarly journals Four-Dimensional (Bio-)printing: A Review on Stimuli-Responsive Mechanisms and Their Biomedical Suitability

2020 ◽  
Vol 10 (24) ◽  
pp. 9143
Author(s):  
Pedro Morouço ◽  
Bahareh Azimi ◽  
Mario Milazzo ◽  
Fatemeh Mokhtari ◽  
Cristiana Fernandes ◽  
...  
Keyword(s):  
Smart Materials ◽  
Biomedical Applications ◽  
Target Stimulus ◽  
Three Dimensional ◽  
Deep Understanding ◽  
Critical Element ◽  
Stimuli Responsive ◽  
Responsive Materials ◽  
Tissue Constructs ◽  
Manufacturing Techniques

The applications of tissue engineered constructs have witnessed great advances in the last few years, as advanced fabrication techniques have enabled promising approaches to develop structures and devices for biomedical uses. (Bio-)printing, including both plain material and cell/material printing, offers remarkable advantages and versatility to produce multilateral and cell-laden tissue constructs; however, it has often revealed to be insufficient to fulfill clinical needs. Indeed, three-dimensional (3D) (bio-)printing does not provide one critical element, fundamental to mimic native live tissues, i.e., the ability to change shape/properties with time to respond to microenvironmental stimuli in a personalized manner. This capability is in charge of the so-called “smart materials”; thus, 3D (bio-)printing these biomaterials is a possible way to reach four-dimensional (4D) (bio-)printing. We present a comprehensive review on stimuli-responsive materials to produce scaffolds and constructs via additive manufacturing techniques, aiming to obtain constructs that closely mimic the dynamics of native tissues. Our work deploys the advantages and drawbacks of the mechanisms used to produce stimuli-responsive constructs, using a classification based on the target stimulus: humidity, temperature, electricity, magnetism, light, pH, among others. A deep understanding of biomaterial properties, the scaffolding technologies, and the implant site microenvironment would help the design of innovative devices suitable and valuable for many biomedical applications.

Near-infrared light-responsive, diselenide containing core-cross-linked micelles prepared by the Diels–Alder click reaction for photocontrollable drug release application

2018 ◽  
Vol 9 (39) ◽  
pp. 4813-4823 ◽  
Author(s):  
Sabrina Aufar Salma ◽  
Maheshkumar Prakash Patil ◽  
Dong Woo Kim ◽  
Cuong Minh Quoc Le ◽  
Byung-Hyun Ahn ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Click Reaction ◽  
Diels Alder ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Micelle System ◽  
Drug Vehicle

We report a facile and efficient preparation of a NIR-triggered micelle system for a drug vehicle.

scholarly journals Stimuli-Responsive Graphene Nanohybrids for Biomedical Applications

2019 ◽  
Vol 2019 ◽  
pp. 1-18 ◽  
Author(s):  
Dinesh K. Patel ◽  
Yu-Ri Seo ◽  
Ki-Taek Lim
Keyword(s):  
Drug Delivery ◽  
Functional Groups ◽  
Hybrid Materials ◽  
Smart Materials ◽  
Biomedical Applications ◽  
Materials Science ◽  
High Surface ◽  
Single Layer ◽  
Stimuli Responsive ◽  
Physiochemical Properties

Stimuli-responsive materials, also known as smart materials, can change their structure and, consequently, original behavior in response to external or internal stimuli. This is due to the change in the interactions between the various functional groups. Graphene, which is a single layer of carbon atoms with a hexagonal morphology and has excellent physiochemical properties with a high surface area, is frequently used in materials science for various applications. Numerous surface functionalizations are possible for the graphene structure with different functional groups, which can be used to alter the properties of native materials. Graphene-based hybrids exhibit significant improvements in their native properties. Since functionalized graphene contains several reactive groups, the behavior of such hybrid materials can be easily tuned by changing the external conditions, which is very useful in biomedical applications. Enhanced cell proliferation and differentiation of stem cells was reported on the surfaces of graphene-based hybrids with negligible cytotoxicity. In addition, pH or light-induced drug delivery with a controlled release rate was observed for such nanohybrids. Besides, notable improvements in antimicrobial activity were observed for nanohybrids, which demonstrated their potential for biomedical applications. This review describes the physiochemical properties of graphene and graphene-based hybrid materials for stimuli-responsive drug delivery, tissue engineering, and antimicrobial applications.

scholarly journals Bio-orthogonal “click-and-release” donation of caged carbonyl sulfide (COS) and hydrogen sulfide (H2S)

2017 ◽  
Vol 53 (8) ◽  
pp. 1378-1380 ◽  
Author(s):  
Andrea K. Steiger ◽  
Yang Yang ◽  
Maksim Royzen ◽  
Michael D. Pluth
Keyword(s):  
Hydrogen Sulfide ◽  
Click Reaction ◽  
Carbonyl Sulfide ◽  
Diels Alder ◽  
Inverse Electron Demand ◽  
New Strategy ◽  
Electron Demand

The inverse-electron demand Diels–Alder (IEDDA) click reaction between thiocarbamate-functionalized trans-cyclooctenes and tetrazines provides a new strategy for bio-orthogonal COS/H2S delivery.

scholarly journals Recent advances on polydiacetylene-based smart materials for biomedical applications

2020 ◽  
Vol 4 (4) ◽  
pp. 1089-1104 ◽  
Author(s):  
Fang Fang ◽  
Fanling Meng ◽  
Liang Luo
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Smart Materials ◽  
Biomedical Applications ◽  
Recent Advances ◽  
Smart Biomaterials

This review summarized most recent advances of designing strategies of polydiacetylene-based smart biomaterials with unique colorimetric and mechanical properties, as well as their applications in biosensing, drug delivery, and tissue engineering.

Application Perspective of Environmentally Responsive Materials in the Downhole Operation

2020 ◽  
Vol 993 ◽  
pp. 799-805
Author(s):  
Gu Fan Zhao ◽  
Wei Na Di
Keyword(s):  
Smart Materials ◽  
Oil And Gas ◽  
Drilling Fluid ◽  
Research Work ◽  
Oil And Gas Industry ◽  
Petroleum Engineering ◽  
Research Progress ◽  
Self Healing ◽  
Responsive Materials ◽  
Environmentally Responsive

Smart materials, especially environmentally responsive materials are the basis of many applications, and have attracted much more attentions. In recent years, application research of smart materials in the oil and gas industry has begun. Through principle/performance analysis, application environment comparison, and demand analysis, the application potential and application advantages of self-healing concrete, vibration energy-generating rubber and 4D intelligent structural materials in the downhole operations were evaluated. The application status of smart materials in petroleum engineering is introduced. At the same time, combined with the actual domestic engineering requirements, the long-term effect of improving underground plugging, the shale inhibition of drilling fluid, the downhole control and the efficiency of drilling operations are all proposed. For the application prospects, it is recommended to keep track of the research progress of environmentally responsive materials and carry out pre-research work on the application of advanced smart materials in the field of downhole operations.

Experimental Model Design and Preliminary Numerical Verification of Fluid–Thermal–Structural Coupling Problem

AIAA Journal ◽  
2019 ◽  
Vol 57 (4) ◽  
pp. 1715-1724 ◽  
Author(s):  
Liu Lei ◽  
Dai Guangyue ◽  
Zeng Lei ◽  
Wang Zhenfeng ◽  
Gui Yewei
Keyword(s):  
Experimental Model ◽  
Numerical Verification ◽  
Model Design ◽  
Structural Coupling ◽  
Coupling Problem

scholarly journals Switchable fluorescence by click reaction of a novel azidocarbazole dye

RSC Advances ◽  
2014 ◽  
Vol 4 (23) ◽  
pp. 11528-11534 ◽  
Author(s):  
Anna Hörner ◽  
Daniel Volz ◽  
Tobias Hagendorn ◽  
Daniel Fürniss ◽  
Lutz Greb ◽  
...  
Keyword(s):  
Smart Materials ◽  
Spectral Properties ◽  
Click Reaction ◽  
New Class

Smart materials: A demand for switchable tags led us to the design of a new class of pre-fluorophores. We achieved this by using a non-fluorescent N-(4-azidophenyl)-carbazole tag which turns fluorescent by click reaction with alkynes and cyclooctynes. Syntheses and spectral properties were investigated.

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