A pH-responsive graftable supramolecular polymer with tailorable surface functionality by orthogonal halogen bonding and hydrogen bonding

2020 ◽  
Vol 11 (2) ◽  
pp. 385-392 ◽  
Author(s):  
Akshoy Jamadar ◽  
Anindita Das
Keyword(s):  
Hydrogen Bonding ◽  
Halogen Bonding ◽  
Supramolecular Polymer ◽  
Ph Responsive ◽  
Surface Functionality ◽  
Temperature Responsive ◽  
Tunable Morphology

Orthogonal halogen (X)-bonding and hydrogen (H)-bonding have been employed for constructing a surface functionalizable supramolecular polymer in water featuring tunable morphology and dual stimuli (pH and temperature) responsive properties.

The Design of Temperature and pH-Responsive Drug Delivery System Based on Cellulose and Aminated Cellulose by Computational and Experimental Methods

2020 ◽  
pp. 1-12
Author(s):  
Enayat Mohsenzadeh ◽  
Hassan Namazi ◽  
Rahim Ghadari
Keyword(s):  
Hydrogen Bonding ◽  
Electrostatic Interactions ◽  
Binding Free Energy ◽  
In Vitro Release ◽  
Md Simulations ◽  
Ph Responsive ◽  
Temperature Responsive ◽  
Repulsive Forces ◽  
Vitro Release

In this study, molecular dynamics (MD) simulations were performed on cellulose and aminated cellulose. Obtained results show the presence of amine moieties and their protonation, positive charges and repulsive forces increase. As a result, the van der Waals and electrostatic interactions and hydrogen bonding number decrease. Then, paclitaxel was loaded through docking into the structures and was studied by MD simulations. The simulations were performed in several protonation states along with 25°C, 37°C, 42°C and 50°C temperatures. The carrier/ligand system behaviors were analyzed. The results indicate the increase of temperature and protonation decrease hydrogen bonding number between drug and carrier and increase binding free energy. At last, to compare the simulations results, paclitaxel was loaded in cellulose and aminated cellulose and investigated in the in vitro release at two conditions (37°C, pH 7.4, and 42°C, pH 5). Experimental results prove computational results as pH/temperature-responsive system.

Construction and morphology of non-covalently double-crosslinked supramolecular polymer networks

2019 ◽  
Vol 10 (34) ◽  
pp. 4740-4745 ◽  
Author(s):  
Senbin Chen ◽  
Ke Wang ◽  
Zhen Geng ◽  
Yu Chen ◽  
Xihuang Zheng ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Polymer Networks ◽  
Functionalized Polymers ◽  
Metal Coordination ◽  
Supramolecular Polymer ◽  
Supramolecular Networks

A straightforward synthesis of α-Ba, ω-TAP functionalized polymers, Ba-PnBuA-TAP, is reported, leading to the formation of double-crosslinked supramolecular networks driven via the sequential hydrogen-bonding association and metal-coordination.

Synergic Interplay Between Halogen Bonding and Hydrogen Bonding in the Activation of a Neutral Substrate in a Nanoconfined Space

2020 ◽  
Vol 59 (2) ◽  
pp. 811-818 ◽  
Author(s):  
Pellegrino La Manna ◽  
Margherita De Rosa ◽  
Carmen Talotta ◽  
Antonio Rescifina ◽  
Giuseppe Floresta ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Halogen Bonding

Selective fluorescence sensing of H2PO4− by the anion induced formation of self-assembled supramolecular polymers

2020 ◽  
Vol 18 (20) ◽  
pp. 3858-3866 ◽  
Author(s):  
Paula Sabater ◽  
Fabiola Zapata ◽  
Adolfo Bastida ◽  
Antonio Caballero
Keyword(s):  
Halogen Bonding ◽  
Supramolecular Polymers ◽  
Supramolecular Polymer ◽  
Fluorescence Sensing ◽  
Tripodal Receptor ◽  
Self Assembled

H2PO4− anions induced the formation of a fluorescent supramolecular polymer by halogen bonding interactions in a bromoimidazolium based tripodal receptor.

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