scholarly journals Influence of ions to modulate hydrazone and oxime reaction kinetics to obtain dynamically cross-linked hyaluronic acid hydrogels

2019 ◽  
Vol 10 (31) ◽  
pp. 4322-4327
Author(s):  
Shujiang Wang ◽  
Ganesh N. Nawale ◽  
Oommen P. Oommen ◽  
Jöns Hilborn ◽  
Oommen P. Varghese
Keyword(s):  
Hyaluronic Acid ◽  
Reaction Kinetics ◽  
Novel Catalyst ◽  
Divalent Salts

Simple monovalent and divalent salts are presented as a novel catalyst for performing hydrazone and oxime coupling chemistry at physiological pH with excellent yields.

Study of C2H5O2 using modulated photolysis: ultra-violet spectrum and self-reaction kinetics in the temperature range 233-363 K

1997 ◽  
Vol 94 ◽  
pp. 484-502
Author(s):  
S Fauvet ◽  
JP Ganne ◽  
J Brion ◽  
D Daumont ◽  
J Malicet ◽  
...  
Keyword(s):  
Reaction Kinetics ◽  
Ultra Violet ◽  
Temperature Range

Healing of Circular Defects in the Rabbit Medial Meniscus Can Occur Spontaneously and Is not Improved by Intra-Articular Hyaluronic Acid

1996 ◽  
Vol 09 (02) ◽  
pp. 60-5 ◽  
Author(s):  
N. Hope ◽  
P. Ghosh ◽  
S. Collier
Keyword(s):  
Hyaluronic Acid ◽  
Medial Meniscus ◽  
Chondroitin Sulphate ◽  
Rabbit Model ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Keratan Sulphate ◽  
Meniscal Healing ◽  
Meniscus Healing ◽  
Made In

SummaryThe aim of this study was to determine the effects of intra-articular hyaluronic acid on meniscal healing. Circular defects, 1.0 mm in diameter, were made in the anterior third of the medial meniscus in rabbits. In one joint, 0.4 ml hyaluronic acid (Healon®) was instilled, and in the contralateral (control) joint, 0.4 ml Ringer’s saline. Four rabbits were killed after four, eight and 12 weeks and the menisci examined histologically. By eight weeks most of the lesions had healed by filling with hyaline-like cartilage. Healing was not improved by hyaluronic acid treatment. The repair tissue stained strongly with alcian blue, and the presence of type II collagen, keratan sulphate, and chondroitin sulphate was demonstrated by immunohistochemical localisation. In contrast to the circular defects, longitudinal incisions made in the medial menisci of a further six rabbits did not show any healing after 12 weeks, indicating that the shape of the lesion largely determined the potential for healing.The effect of hyaluronic acid on meniscal healing was tested in a rabbit model. With one millimeter circular lesions in the medial meniscus, healing by filling with hyalinelike cartilage was not significantly affected by the application of hyaluronic acid intra-articularly at the time of surgery, compared to saline controls, as assessed histologically four, eight and 12 weeks after the operation.

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