Polysaccharides meet dendrimers to fine-tune the stability and release properties of polyion complex micelles

2019 ◽  
Vol 10 (34) ◽  
pp. 4709-4717 ◽  
Author(s):  
Roi Lopez-Blanco ◽  
Marcos Fernandez-Villamarin ◽  
Sorel Jatunov ◽  
Ramon Novoa-Carballal ◽  
Eduardo Fernandez-Megia
Keyword(s):  
Drug Release ◽  
Delivery Systems ◽  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
The Stability ◽  
Complex Micelles ◽  
Kinetics Of ◽  
Fine Tune

Dendritic-polysaccharide PIC micelles represent promising delivery systems where dendritic rigidity and polysaccharide stiffness synchronize to determine the stability of the micelles, their kinetics of intracellular drug release, and cytotoxicity.

scholarly journals A dendrimer–hydrophobic interaction synergy improves the stability of polyion complex micelles

2017 ◽  
Vol 8 (16) ◽  
pp. 2528-2537 ◽  
Author(s):  
Marcos Fernandez-Villamarin ◽  
Ana Sousa-Herves ◽  
Silvia Porto ◽  
Noelia Guldris ◽  
José Martínez-Costas ◽  
...  
Keyword(s):  
Hydrophobic Interaction ◽  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
The Stability ◽  
Complex Micelles

Dendritic Macromolecular Architectures: Dendrimer-Based Polyion Complex Micelles

2021 ◽  
Vol 22 (2) ◽  
pp. 262-274
Author(s):  
Serge Mignani ◽  
Xiangyang Shi ◽  
Maria Zablocka ◽  
Jean-Pierre Majoral
Keyword(s):  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
Complex Micelles

scholarly journals Effect of Mixing Ratio of Oppositely Charged Block Copolymers on Polyion Complex Micelles for In Vivo Application

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 5
Author(s):  
Noriko Nakamura ◽  
Yuki Mochida ◽  
Kazuko Toh ◽  
Shigeto Fukushima ◽  
Horacio Cabral ◽  
...  
Keyword(s):  
Physicochemical Characteristics ◽  
Charge Ratio ◽  
Structural Variations ◽  
Polyion Complex ◽  
Functional Capabilities ◽  
The Stability ◽  
Biological Performance ◽  
Complex Micelles ◽  
Oppositely Charged

Self-assembled supramolecular structures based on polyion complex (PIC) formation between oppositely charged polymers are attracting much attention for developing drug delivery systems able to endure harsh in vivo environments. As controlling polymer complexation provides an opportunity for engineering the assemblies, an improved understanding of the PIC formation will allow constructing assemblies with enhanced structural and functional capabilities. Here, we focused on the influence of the mixing charge ratio between block aniomers and catiomers on the physicochemical characteristics and in vivo biological performance of the resulting PIC micelles (PIC/m). Our results showed that by changing the mixing charge ratio, the structural state of the core was altered despite the sizes of PIC/m remaining almost the same. These structural variations greatly affected the stability of the PIC/m in the bloodstream after intravenous injection and determined their biodistribution.

pH-sensitive polyion complex micelles for tunable intracellular drug delivery

2015 ◽  
Vol 213 ◽  
pp. e55
Author(s):  
Jinjin Chen ◽  
Ying Zhang ◽  
Jianxun Ding ◽  
Chunsheng Xiao ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
Intracellular Drug Delivery ◽  
Complex Micelles
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