3D printed self-adhesive PEGDA–PAA hydrogels as modular components for soft actuators and microfluidics

2019 ◽  
Vol 10 (16) ◽  
pp. 2015-2028 ◽  
Author(s):  
Thomas M. Valentin ◽  
Eric M. DuBois ◽  
Catherine E. Machnicki ◽  
Dhananjay Bhaskar ◽  
Francis R. Cui ◽  
...  
Keyword(s):  
Microfluidic Devices ◽  
Building Blocks ◽  
Stimuli Responsive ◽  
3D Printed ◽  
Do It Yourself ◽  
Soft Actuators

Hydrogel building blocks that are stimuli-responsive and self-adhesive could be utilized as a simple “do-it-yourself” construction set for soft machines and microfluidic devices.

scholarly journals Four-dimensional micro-building blocks

2020 ◽  
Vol 6 (3) ◽  
pp. eaav8219 ◽  
Author(s):  
T.-Y. Huang ◽  
H.-W. Huang ◽  
D. D. Jin ◽  
Q. Y. Chen ◽  
J. Y. Huang ◽  
...  
Keyword(s):  
Design Principle ◽  
Modular Design ◽  
Building Blocks ◽  
Stimuli Responsive ◽  
Race Car ◽  
Two Photon ◽  
Direct Laser ◽  
3D Printed ◽  
Reconfigurable Structures ◽  
Responsive Hydrogels

Four-dimensional (4D) printing relies on multimaterial printing, reinforcement patterns, or micro/nanofibrous additives as programmable tools to achieve desired shape reconfigurations. However, existing programming approaches still follow the so-called origami design principle to generate reconfigurable structures by self-folding stacked 2D materials, particularly at small scales. Here, we propose a programmable modular design that directly constructs 3D reconfigurable microstructures capable of sophisticated 3D-to-3D shape transformations by assembling 4D micro-building blocks. 4D direct laser writing is used to print two-photon polymerizable, stimuli-responsive hydrogels to construct building blocks at micrometer scales. Denavit-Hartenberg (DH) parameters, used to define robotic arm kinematics, are introduced as guidelines for how to assemble the micro-building blocks and plan the 3D motion of assembled chain blocks. Last, a 3D-printed microscaled transformer capable of changing its shape from a race car to a humanoid robot is devised and fabricated using the DH parameters to guide the motion of various assembled compartments.

Advanced Hydrogels Based Drug Delivery Systems for Ophthalmic Delivery

2020 ◽  
Vol 13 (4) ◽  
pp. 291-300 ◽  
Author(s):  
Srividya Gorantla ◽  
Tejashree Waghule ◽  
Vamshi Krishna Rapalli ◽  
Prem Prakash Singh ◽  
Sunil Kumar Dubey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Age Related Macular Degeneration ◽  
Stimuli Responsive ◽  
Duration Of Action ◽  
Age Related ◽  
Aqueous Gels ◽  
Ophthalmic Delivery ◽  
3D Printed

Hydrogels are aqueous gels composed of cross-linked networks of hydrophilic polymers. Stimuli-responsive based hydrogels have gained focus over the past 20 years for treating ophthalmic diseases. Different stimuli-responsive mechanisms are involved in forming polymer hydrogel networks, including change in temperature, pH, ions, and others including light, thrombin, pressure, antigen, and glucose-responsive. Incorporation of nanocarriers with these smart stimuli-responsive drug delivery systems that can extend the duration of action by increasing ocular bioavailability and reducing the dosing frequency. This review will focus on the hydrogel drug delivery systems highlighting the gelling mechanisms and emerging stimuli-responsive hydrogels from preformed gels, nanogels, and the role of advanced 3D printed hydrogels in vision-threatening diseases like age-related macular degeneration and retinitis pigmentosa. It also provides insight into the limitations of hydrogels along with the safety and biocompatibility of the hydrogel drug delivery systems.

Automated calibration of 3D-printed microfluidic devices based on computer vision

2021 ◽  
Vol 15 (2) ◽  
pp. 024102
Author(s):  
Junchao Wang ◽  
Kaicong Liang ◽  
Naiyin Zhang ◽  
Hailong Yao ◽  
Tsung-Yi Ho ◽  
...  
Keyword(s):  
Computer Vision ◽  
Microfluidic Devices ◽  
Automated Calibration ◽  
3D Printed

scholarly journals Rapid Production of PDMS Microdevices for Electrodriven Separations and Microfluidics by 3D-Printed Scaffold Removal

Separations ◽  
2021 ◽  
Vol 8 (5) ◽  
pp. 67
Author(s):  
Alena Šustková ◽  
Klára Konderlová ◽  
Ester Drastíková ◽  
Stefan Sützl ◽  
Lenka Hárendarčíková ◽  
...  
Keyword(s):  
Organic Dyes ◽  
Microfluidic Devices ◽  
Proof Of Concept ◽  
Magnetic Microparticles ◽  
Mechanical Removal ◽  
Glass Slides ◽  
Rapid Production ◽  
3D Printed

In our work, we produced PDMS-based microfluidic devices by mechanical removal of 3D-printed scaffolds inserted in PDMS. Two setups leading to the fabrication of monolithic PDMS-based microdevices and bonded (or stamped) PDMS-based microdevices were designed. In the monolithic devices, the 3D-printed scaffolds were fully inserted in the PDMS and then carefully removed. The bonded devices were produced by forming imprints of the 3D-printed scaffolds in PDMS, followed by bonding the PDMS parts to glass slides. All these microfluidic devices were then successfully employed in three proof-of-concept applications: capture of magnetic microparticles, formation of droplets, and isotachophoresis separation of model organic dyes.

scholarly journals 3D printed microfluidic devices with immunoaffinity monoliths for extraction of preterm birth biomarkers

2018 ◽  
Vol 411 (21) ◽  
pp. 5405-5413 ◽  
Author(s):  
Ellen K. Parker ◽  
Anna V. Nielsen ◽  
Michael J. Beauchamp ◽  
Haifa M. Almughamsi ◽  
Jacob B. Nielsen ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Microfluidic Devices ◽  
3D Printed

scholarly journals Dragonfly Inspired Smart Soft Robot

2020 ◽  
Author(s):  
Vardhman Kumar ◽  
Ung Hyun Ko ◽  
Yilong Zhou ◽  
Jiaul Hoque ◽  
Gaurav Arya ◽  
...  
Keyword(s):  
Environmental Remediation ◽  
Stimuli Responsive ◽  
Complex Environments ◽  
Soft Robots ◽  
Responsive Materials ◽  
Environmental Perturbations ◽  
Integration Strategies ◽  
Soft Actuators ◽  
Harsh Conditions

Recent advancements in soft robotics have led to the development of compliant robots that can exhibit complex motions driven by living cells(1, 2), chemical reactions(3), or electronics(4). Further innovations are however needed to create the next generation of soft robots that can carry out advanced functions beyond locomotion. Here we describe DraBot—a dragonfly-inspired, entirely soft, multifunctional robot that combines long-term locomotion over water surface with sensing, responding, and adaptation capabilities. By integrating soft actuators, stimuli-responsive materials, and microarchitectural features, we created a circuitry of pneumatic and microfluidic logic that enabled the robot to undergo user- and environment-controlled (pH) locomotion, including navigating hazardous (acidic) conditions. DraBot was also engineered to sense additional environmental perturbations (temperature) and detect and clean up chemicals (oil). The design, fabrication, and integration strategies demonstrated here pave a way for developing futuristic soft robots that can acclimatize and adapt to harsh conditions while carrying out complex tasks such as exploration, environmental remediation, and health care in complex environments.

scholarly journals Using Spheroids as Building Blocks Towards 3D Bioprinting of Tumor Microenvironment

2021 ◽  
Vol 7 (4) ◽  
pp. 444
Author(s):  
Pei Zhuang ◽  
Yi-Hua Chiang ◽  
Maria Serafim Fernanda ◽  
Mei He
Keyword(s):  
Tumor Microenvironment ◽  
Prediction Models ◽  
Three Dimensional ◽  
3D Culture ◽  
Building Blocks ◽  
3D Bioprinting ◽  
Multicellular Spheroids ◽  
Tumor Models ◽  
3D Printed

Cancer still ranks as a leading cause of mortality worldwide. Although considerable efforts have been dedicated to anticancer therapeutics, progress is still slow, partially due to the absence of robust prediction models. Multicellular tumor spheroids, as a major three-dimensional (3D) culture model exhibiting features of avascular tumors, gained great popularity in pathophysiological studies and high throughput drug screening. However, limited control over cellular and structural organization is still the key challenge in achieving in vivo like tissue microenvironment. 3D bioprinting has made great strides toward tissue/organ mimicry, due to its outstanding spatial control through combining both cells and materials, scalability, and reproducibility. Prospectively, harnessing the power from both 3D bioprinting and multicellular spheroids would likely generate more faithful tumor models and advance our understanding on the mechanism of tumor progression. In this review, the emerging concept on using spheroids as a building block in 3D bioprinting for tumor modeling is illustrated. We begin by describing the context of the tumor microenvironment, followed by an introduction of various methodologies for tumor spheroid formation, with their specific merits and drawbacks. Thereafter, we present an overview of existing 3D printed tumor models using spheroids as a focus. We provide a compilation of the contemporary literature sources and summarize the overall advancements in technology and possibilities of using spheroids as building blocks in 3D printed tissue modeling, with a particular emphasis on tumor models. Future outlooks about the wonderous advancements of integrated 3D spheroidal printing conclude this review.

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