scholarly journals Diastereoselective synthesis of trisubstituted olefins using a silicon-tether ring-closing metathesis strategy

2020 ◽  
Vol 18 (12) ◽  
pp. 2297-2306
Author(s):  
Stéphane Wittmann ◽  
Alexander F. Tiniakos ◽  
Joëlle Prunet
Keyword(s):  
Diastereoselective Synthesis ◽  
Ring Closing Metathesis ◽  
Trisubstituted Olefins ◽  
Trisubstituted Alkenes

We report an efficient and diastereoselective synthesis of E- and Z-trisubstituted alkenes by a silicon-tether ring-closing metathesis strategy.

An Enantio- and Diastereoselective Synthesis of Fluorinated β-Aminoalkyl­oxepine Derivatives through Mannich and Ring-Closing Metathesis Reactions

Synthesis ◽  
2006 ◽  
Vol 2006 (23) ◽  
pp. 4087-4091 ◽  
Author(s):  
Santos Fustero ◽  
Elisabet Esteban ◽  
Juan Sanz-Cervera ◽  
Diego Jiménez ◽  
Fatemeh Mojarrad
Keyword(s):  
Diastereoselective Synthesis ◽  
Ring Closing Metathesis ◽  
Metathesis Reactions

scholarly journals Diastereoselective Synthesis of Fluorinated, Seven-Membered β-Amino Acid Derivatives via Ring-Closing Metathesis.

ChemInform ◽  
2003 ◽  
Vol 34 (48) ◽  
Author(s):  
Santos Fustero ◽  
Ana Bartolome ◽  
Juan F. Sanz-Cervera ◽  
Maria Sanchez-Rosello ◽  
Juan Garcia Soler ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Diastereoselective Synthesis ◽  
Ring Closing Metathesis

Diastereoselective Synthesis of trans -2,3-Diaryl(heteroaryl)-3,6-dihydropyrans by an Allylboration/Ring-Closing-Metathesis Sequence

2017 ◽  
Vol 2017 (23) ◽  
pp. 3343-3354 ◽  
Author(s):  
Pierre-Antoine Nocquet ◽  
Andrei Corbu ◽  
Lieven Meerpoel ◽  
Ian Stansfield ◽  
Didier Berthelot ◽  
...  
Keyword(s):  
Diastereoselective Synthesis ◽  
Ring Closing Metathesis

Diastereoselective Synthesis of P-Stereogenic Heterocycles via Enyne Ring-Closing Metathesis

2010 ◽  
Vol 12 (6) ◽  
pp. 1236-1239 ◽  
Author(s):  
James Stephen Harvey ◽  
Guy T. Giuffredi ◽  
Véronique Gouverneur
Keyword(s):  
Diastereoselective Synthesis ◽  
Ring Closing Metathesis

scholarly journals A Relay Strategy Actuates Pre-Existing Trisubstituted Olefins in Monoterpenoids to Form New Trisubstituted Olefins by Cross Metathesis

2019 ◽  
Author(s):  
Karim Bahou ◽  
D. Christopher Braddock ◽  
Adam G. Meyer ◽  
G. Paul Savage ◽  
Zhensheng Shi ◽  
...  
Keyword(s):  
Geometrical Isomer ◽  
Successful Implementation ◽  
Enantiomerically Pure ◽  
Cross Metathesis ◽  
Trisubstituted Olefins ◽  
The Cross ◽  
Trisubstituted Alkenes

<b><u>Abstract:</u></b> A retrosynthetic disconnection-reconnection analysis of epoxypolyenes – substrates that can undergo cyclization to podocarpane-type tricycles – reveals relay-actuated Δ<sup>6,7</sup>-functionalized monoterpenoid alcohols for ruthenium benzylidene catalyzed olefin cross metathesis with homoprenyl benzenes. Successful implementation of this approach provided several epoxypolyenes as expected (<i>E</i>:<i>Z</i>, ca. 2-3:1). The method is further generalized for the cross metathesis of pre-existing trisubstituted olefins in other relay-actuated Δ<sup>6,7</sup>-functionalized monoterpenoid alcohols with various other trisubstituted alkenes to form new trisubstituted olefins. Epoxypolyene cyclization of an enantiomerically pure, but geometrically impure, epoxypolyene substrate provides an enantiomerically pure, trans-fused, podocarpane-type tricycle (from the <i>E</i>-geometrical isomer).<br>

scholarly journals A Relay Strategy Actuates Pre-Existing Trisubstituted Olefins in Monoterpenoids for Cross-Metathesis with Trisubstituted Alkenes

2020 ◽  
Vol 85 (7) ◽  
pp. 4906-4917 ◽  
Author(s):  
Karim A. Bahou ◽  
D. Christopher Braddock ◽  
Adam G. Meyer ◽  
G. Paul Savage ◽  
Zhensheng Shi ◽  
...  
Keyword(s):  
Cross Metathesis ◽  
Trisubstituted Olefins ◽  
Trisubstituted Alkenes

ChemInform Abstract: Diastereoselective Synthesis of P-Stereogenic Heterocycles via Enyne Ring-Closing Metathesis.

ChemInform ◽  
2010 ◽  
Vol 41 (31) ◽  
pp. no-no
Author(s):  
James Stephen Harvey ◽  
Guy T. Giuffredi ◽  
Veronique Gouverneur
Keyword(s):  
Diastereoselective Synthesis ◽  
Ring Closing Metathesis
Sign in / Sign up

Export Citation Format

Share Document