scholarly journals Base-catalyzed C-alkylation of potassium enolates with styrenes via a metal–ene reaction: a mechanistic study

2020 ◽  
Vol 18 (11) ◽  
pp. 2063-2075 ◽  
Author(s):  
Joshua P. Barham ◽  
Thierry N. J. Fouquet ◽  
Yasuo Norikane
Keyword(s):  
Kinetic Studies ◽  
Mechanistic Study ◽  
Ene Reaction ◽  
Practical Synthesis

Base-catalyzed, C-Alkylation of potassium (K) Enolates with Syrenes (CAKES) enables practical synthesis or elaboration of pharmaceutical cores via a thusfar elusive mechanism. Herein, computational (DFT) and kinetic studies back a metal-ene reaction.

Mechanistic and kinetic studies of elemental mercury oxidation over a RuO2/rutile TiO2 catalyst

2017 ◽  
Vol 7 (20) ◽  
pp. 4669-4679 ◽  
Author(s):  
Zhouyang Liu ◽  
Vishnu Sriram ◽  
Can Li ◽  
Joo-Youp Lee
Keyword(s):  
Kinetic Study ◽  
Ruthenium Oxide ◽  
Kinetic Studies ◽  
Elemental Mercury ◽  
Oxidation Catalyst ◽  
Mechanistic Study ◽  
Mercury Oxidation ◽  
Rutile Tio2 ◽  
Tio2 Catalyst

A mechanistic study using in situ DRIFTS and a kinetic study were conducted on a ruthenium oxide based mercury oxidation catalyst.

scholarly journals Correction: Base-catalyzed C-alkylation of potassium enolates with styrenes via a metal–ene reaction: a mechanistic study

2020 ◽  
Vol 18 (13) ◽  
pp. 2538-2538
Author(s):  
Joshua P. Barham ◽  
Thierry N. J. Fouquet ◽  
Yasuo Norikane
Keyword(s):  
Mechanistic Study ◽  
Ene Reaction

Correction for ‘Base-catalyzed C-alkylation of potassium enolates with styrenes via a metal–ene reaction: a mechanistic study’ by Joshua P. Barham et al., Org. Biomol. Chem., 2020, DOI: 10.1039/c9ob02495f.

ChemInform Abstract: Practical Synthesis and Mechanistic Study of Polysubstituted Tetrahydropyrimidines with Use of Domino Multicomponent Reactions.

ChemInform ◽  
2009 ◽  
Vol 40 (39) ◽  
Author(s):  
Qiuhua Zhu ◽  
Huanfeng Jiang ◽  
Jinghao Li ◽  
Min Zhang ◽  
Xiujun Wang ◽  
...  
Keyword(s):  
Multicomponent Reactions ◽  
Mechanistic Study ◽  
Practical Synthesis

Practical synthesis and mechanistic study of polysubstituted tetrahydropyrimidines with use of domino multicomponent reactions

Tetrahedron ◽  
2009 ◽  
Vol 65 (23) ◽  
pp. 4604-4613 ◽  
Author(s):  
Qiuhua Zhu ◽  
Huanfeng Jiang ◽  
Jinghao Li ◽  
Min Zhang ◽  
Xiujun Wang ◽  
...  
Keyword(s):  
Multicomponent Reactions ◽  
Mechanistic Study ◽  
Practical Synthesis

A Practical Synthesis of the Phytosiderophore 2′-Deoxymugineic Acid: A Key to the Mechanistic Study of Iron Acquisition by Graminaceous Plants

2007 ◽  
Vol 119 (37) ◽  
pp. 7190-7193 ◽  
Author(s):  
Kosuke Namba ◽  
Yoshiko Murata ◽  
Manabu Horikawa ◽  
Takashi Iwashita ◽  
Shoichi Kusumoto
Keyword(s):  
Iron Acquisition ◽  
Mechanistic Study ◽  
Deoxymugineic Acid ◽  
Practical Synthesis ◽  
Graminaceous Plants

Flavin radicals, conformational sampling and robust design principles in interprotein electron transfer: the trimethylamine dehydrogenase-electron-transferring flavoprotein complex

2004 ◽  
Vol 71 ◽  
pp. 1-14
Author(s):  
David Leys ◽  
Jaswir Basran ◽  
François Talfournier ◽  
Kamaldeep K. Chohan ◽  
Andrew W. Munro ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Dimensional Space ◽  
Three Dimensional ◽  
Kinetic Studies ◽  
Molecular Assembly ◽  
Conformational Sampling ◽  
Trimethylamine Dehydrogenase ◽  
Key Residues ◽  
Electron Transferring Flavoprotein ◽  
Electron Transfer Complex

TMADH (trimethylamine dehydrogenase) is a complex iron-sulphur flavoprotein that forms a soluble electron-transfer complex with ETF (electron-transferring flavoprotein). The mechanism of electron transfer between TMADH and ETF has been studied using stopped-flow kinetic and mutagenesis methods, and more recently by X-ray crystallography. Potentiometric methods have also been used to identify key residues involved in the stabilization of the flavin radical semiquinone species in ETF. These studies have demonstrated a key role for 'conformational sampling' in the electron-transfer complex, facilitated by two-site contact of ETF with TMADH. Exploration of three-dimensional space in the complex allows the FAD of ETF to find conformations compatible with enhanced electronic coupling with the 4Fe-4S centre of TMADH. This mechanism of electron transfer provides for a more robust and accessible design principle for interprotein electron transfer compared with simpler models that invoke the collision of redox partners followed by electron transfer. The structure of the TMADH-ETF complex confirms the role of key residues in electron transfer and molecular assembly, originally suggested from detailed kinetic studies in wild-type and mutant complexes, and from molecular modelling.

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