Metal-free oxidative acylation/cyclization of N-methacryloyl-2-phenylbenzoimidazole with aryl aldehydes: an easy access to benzimidazo[2,1-a]isoquinolin-6(5H)-ones

2019 ◽  
Vol 17 (44) ◽  
pp. 9627-9630 ◽  
Author(s):  
Ramesh Boora ◽  
G. Ravi kumar ◽  
B. V. Subba Reddy
Keyword(s):  
Free Radical ◽  
Radical Cyclization ◽  
Easy Access ◽  
Metal Free ◽  
Aryl Aldehydes

A metal-free radical cyclization strategy has been developed for the synthesis of fused benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives using 70% tert-butylhydroperoxide in water (TBHP).

Microwave-assisted synthesis of hydroxyl-containing isoquinolines by metal-free radical cyclization of vinyl isocyanides with alcohols

2017 ◽  
Vol 15 (47) ◽  
pp. 10044-10052 ◽  
Author(s):  
Dengqi Xue ◽  
Hao Chen ◽  
Yulong Xu ◽  
Haihua Yu ◽  
Linqian Yu ◽  
...  
Keyword(s):  
Free Radical ◽  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Microwave Assisted Synthesis ◽  
Metal Free ◽  
Microwave Assisted

A convenient microwave-assisted protocol for the synthesis of hydroxyl-containing isoquinolines from a metal-free radical cyclization reaction of vinyl isonitriles with alcohols was developed with moderate-to-excellent yields.

Metal-Free Radical Cyclization of Vinyl Isocyanides with Alkanes: Synthesis of 1-Alkylisoquinolines

Synthesis ◽  
2018 ◽  
Vol 51 (04) ◽  
pp. 874-884 ◽  
Author(s):  
Liming Shao ◽  
Dengqi Xue ◽  
Yijie Xue ◽  
Haihua Yu
Keyword(s):  
Free Radical ◽  
Isotope Effect ◽  
Kinetic Isotope Effect ◽  
Functional Group ◽  
Radical Cyclization ◽  
Diverse Range ◽  
Radical Process ◽  
Metal Free ◽  
Kinetic Isotope ◽  
Inhibition Studies

A metal-free radical cyclization reaction of vinyl isocyanides with alkanes is developed, allowing convenient access to a diverse range of potentially valuable 1-alkylisoquinolines. The methodology is simple and efficient, demonstrating excellent functional group tolerance and broad substrate scope. A mechanism involving a radical process is supported by kinetic isotope effect and radical inhibition studies.

An Easy Access to Sulfur Derivatives of 6,8-Dioxabicyclo[3.2.1]octanes, Naturally Abundant Scaffolds

Synthesis ◽  
2018 ◽  
Vol 50 (13) ◽  
pp. 2624-2630 ◽  
Author(s):  
Elena Schmidt ◽  
Ivan Bidusenko ◽  
Igor Ushakov ◽  
Nadezhda Protsuk ◽  
Boris Trofimov
Keyword(s):  
Natural Products ◽  
Free Radical ◽  
Transition Metal ◽  
Uv Irradiation ◽  
Radical Reaction ◽  
Easy Access ◽  
Free Radical Reaction ◽  
One Pot ◽  
Metal Free ◽  
Derivatives Of

Sulfur derivatives of 6,8-dioxabicyclo[3.2.1]octanes related to a number of natural products have been synthesized by the click hydrothiolation (AIBN or UV irradiation) of 7-methylene-6,8-dioxabicy­clo[3.2.1]octanes, assembled from acetylene and ketones in a one-pot transition-metal-free synthetic operation. An unusual feature of this free-radical reaction is that it is accelerated in the presence of bases due to involvement of the latter in a competition between the thiol addition and proton-catalyzed isomerization of the starting bicyclooctanes.

Synthesis of 6-Trichloromethylphenanthridines by Transition Metal-Free Radical Cyclization of 2-Isocyanobiphenyls

2016 ◽  
Vol 81 (12) ◽  
pp. 5202-5208 ◽  
Author(s):  
Yuhan Zhou ◽  
Changpeng Wu ◽  
Xiaoliang Dong ◽  
Jingping Qu
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Radical Cyclization ◽  
Metal Free

Deaminative carbonylative thioesterification of activated alkylamines with thiophenols under transition-metal-free conditions

2021 ◽  
Author(s):  
Fengqian Zhao ◽  
Xiao-Feng Wu
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Metal Free

A transition-metal-free radical carbonylation of activated alkylamines with thiophenols has been successfully developed. Various thioesters were selectively produced with moderate to good yields.

A metal-free radical cascade reaction of phosphine oxides with 2-aryloxy phenylacetylenes to assemble diphosphonyl xanthene derivatives

2021 ◽  
Author(s):  
Tao Fan ◽  
Yan Liu ◽  
Caina Jiang ◽  
Yanli Xu ◽  
Yan-Yan Chen
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Cascade Reaction ◽  
Phosphine Oxides ◽  
Metal Free ◽  
Mild Conditions ◽  
Xanthene Derivatives ◽  
Reaction Proceeds ◽  
Radical Cascade

A radical cascade reaction of 2-aryloxy phenylacetylene with phosphine oxides promoted by K2S2O8 was developed, provided diphosphonyl xanthenes as products. This reaction proceeds under transition metal-free and mild conditions with...

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