A route to access imidazol[1,5-a]indole-1,3-diones and pyrrolo[1,2-c]imidazole-1,3-diones

2019 ◽  
Vol 17 (36) ◽  
pp. 8384-8390 ◽  
Author(s):  
Ramana Sreenivasa Rao ◽  
Femil Joseph Shajan ◽  
D. Srinivasa Reddy
Keyword(s):  
Column Chromatography ◽  
Present Method ◽  
Practical Method ◽  
Work Up

A simple and practical method for synthesizing imidazol[1,5-a]indoles and pyrrolo[1,2-c]imidazoles has been developed. The present method uses microwave conditions and is free from the need for work-up and column chromatography.

scholarly journals Highly Efficient Synthesis of (Phosphinodihydrooxazole)- (1,5-cyclooctadiene) Iridium Complexes

2009 ◽  
Vol 64 (10) ◽  
pp. 1147-1158 ◽  
Author(s):  
Volodymyr Semeniuchenko ◽  
Volodymyr Khilya ◽  
Ulrich Groth
Keyword(s):  
Column Chromatography ◽  
Present Method ◽  
Iridium Complexes ◽  
Efficient Synthesis ◽  
One Pot ◽  
Highly Efficient

A highly efficient one-pot procedure for the synthesis of complexes of the type [Ir(COD)(Phox)]X, where Phox is a (chiral) phosphinooxazoline ligand, X = PF6 or B[(3,5-(CF3)2C6H3)]4 (BARF), is developed. Former reported syntheses demanded the isolation of pure ligands by column chromatography, but the ligands tend to adsorb irreversibly on silica. Moreover, the chromatography has to be performed with careful exclusion of air. The present method avoids this difficulties. The yields of the syntheses are comparable with those starting from the pure ligands. The method is also suitable for the preparation of complexes of the type [Rh(COD)(Phox)]BARF and [Rh(Phox)2]BARF.

Direct measurement of Fe isotope compositions in iron-dominate minerals without column chromatography using MC-ICP-MS

2022 ◽  
Author(s):  
Kaiyun Chen ◽  
Zhian Bao ◽  
Honglin Yuan ◽  
Nan Lv
Keyword(s):  
Mass Spectrometry ◽  
Direct Measurement ◽  
High Precision ◽  
Column Chromatography ◽  
Inductively Coupled Plasma ◽  
Practical Method ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Isotope Determination

This study presents a practical method for high-precision Fe isotope determination without column chromatography purification for iron-dominated mineral samples using multi-collector inductively coupled plasma-mass spectrometry (MC-ICP-MS). A series of comparable...

Synthesis of 1H-Chromeno[2,3-d]Pyrimidine-5-Carboxamides under Solvent-Free Conditions at Ambient Temperature

2017 ◽  
Vol 41 (2) ◽  
pp. 85-87 ◽  
Author(s):  
Ghodsyeh Keykha ◽  
Mohammad R. Hosseini-Tabatabaei ◽  
Alireza Hassanabadi
Keyword(s):  
Ambient Temperature ◽  
Present Method ◽  
Barbituric Acid ◽  
Condensation Product ◽  
Solvent Free ◽  
One Pot ◽  
Short Reaction Time ◽  
Alkyl Isocyanide ◽  
Solvent Free Conditions ◽  
Work Up

Good yields of six 1H-chromeno[2,3-d]pyrimidine-5-carboxamides were obtained via the two-stage, one-pot reaction of an alkyl isocyanide with the initially formed condensation product of 1,3-dimethyl barbituric acid and a salicylaldehyde under solvent-free conditions at ambient temperature. This procedure has a number of advantages, such as short reaction time and easy work-up. Also, the present method does not involve any hazardous organic solvent.

Nanofibre Sepiolite Catalyzed Green and Rapid Synthesis of 2-Amino-4H-chromene Derivatives

2018 ◽  
Vol 71 (1) ◽  
pp. 32 ◽  
Author(s):  
Arezou Mohammadinezhad ◽  
Batool Akhlaghinia
Keyword(s):  
Column Chromatography ◽  
Present Method ◽  
Simple Procedure ◽  
Reaction Times ◽  
Significant Decline ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Rapid Synthesis ◽  
One Pot ◽  
Highly Efficient

Nanofibre sepiolite catalyzed the rapid, clean, and highly efficient synthesis of 2-amino-4H-chromene derivatives by a one-pot, three-component condensation of a series of aldehydes, various enolizable C–H bonds (such as dimedone, α-naphthol, resorcinol, and 4-hydroxy-2H-chromen-2-one), and malononitrile in a mixture of water/ethanol. The present method offers several advantages such as high to excellent yields, short reaction times, mild reaction conditions, simple procedure, use of inexpensive, non-toxic, and naturally available catalyst, easy isolation of the products, and no need for column chromatography. The catalyst could be easily separated from the reaction mixture and can be reused for many consecutive trials without a significant decline in its reactivity.

scholarly journals NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines

2020 ◽  
Vol 11 (4) ◽  
pp. 276-279
Author(s):  
Gajanan Gopinath Mandawad ◽  
Baseer Mubeen Shaikh ◽  
Santosh Subhash Chobe ◽  
Shankaraiah Guruvaiah Konda
Keyword(s):  
Polyethylene Glycol ◽  
Reaction Time ◽  
Present Method ◽  
Spectroscopic Methods ◽  
Reaction Conditions ◽  
Environment Friendly ◽  
Peg 400 ◽  
High Yields ◽  
Work Up

A simple and eloquent procedure for the synthesis of a new series of thienyl benzo[b]1,4-diazepines is reported. They were synthesized by the condensation of o-phenylenediamine (o-PDA) with distinct hetero chalcones using NaOH in polyethylene glycol (PEG-400) as green and alternative reaction solvent. The significances of this present method are shorter reaction time, easy work-up, high yields, and mild reaction conditions. Furthermore, this method is environment friendly and without use of an expensive catalyst. The all newly synthesized compounds are characterized by the spectroscopic methods.

On a Table for the Formation of Logarithms and Anti-Logarithms to Twelve Places

1865 ◽  
Vol 12 (2) ◽  
pp. 71-100
Author(s):  
Peter Gray
Keyword(s):  
Present Method ◽  
Practical Method ◽  
Peculiar Form ◽  
Limited Scale ◽  
The Given

With the exception of the publication on a more limited scale (and which will be hereafter referred to), of that which is now to be developed, there exists at present no ready and practical method of forming to more than seven places the logarithms of numbers of more than seven or eight figures. The great extent of the tables requisite, if formed on the plan of our present seven-figure tables, is not only likely ever to prove a bar to their construction, but it would also render them too cumbrous, if constructed, to be easily and readily used. In the present method, the end in view is sought to be attained in another way. The principle of the method is the resolution of the number whose logarithm is required, by a direct and easy process, into factors of a peculiar form, the logarithms of which, to the requisite extent, admit of easy tabulation. The logarithms of the factors, then, being taken from the table, their sum is the logarithm of the given number.

A practical method for the generation of organoarsenic nucleophiles towards the construction of a versatile arsenic library

2016 ◽  
Vol 45 (19) ◽  
pp. 7937-7940 ◽  
Author(s):  
Susumu Tanaka ◽  
Hiroaki Imoto ◽  
Takuji Kato ◽  
Kensuke Naka
Keyword(s):  
Present Method ◽  
Bond Formation ◽  
Practical Method ◽  
Promising Ligand

Organoarsenic nucleophiles were easily and safely prepared, leading to a practical method for As–C bond formation. Promising ligand structures such as asymmetric and bidentate types can be widely constructed by the present method.

scholarly journals Synthesis of 1,2,5,6- and 1,4,5,8-Anthracenetetrone: Building Blocks for π-Conjugated Small Molecules and Polymers

2018 ◽  
Author(s):  
Florian Glöcklhofer ◽  
Berthold Stöger ◽  
Johannes Fröhlich
Keyword(s):  
Molecular Structure ◽  
Crystal Structure ◽  
Small Molecules ◽  
Organic Synthesis ◽  
Column Chromatography ◽  
Scale Up ◽  
Building Blocks ◽  
Work Load ◽  
Conjugated Compounds ◽  
Work Up

Reliable reactions for the synthesis of two interesting anthracenetetrones have been identified and optimized. Both syntheses start from dihydroxy-9,10-anthraquinones and were selected for maximized efficiency and minimized work load. Work-up of all reactions can be achieved without column chromatography, which facilitates further scale-up. So far, both target compounds are considerably underexplored despite their promising molecular structure for use in devices and in organic synthesis, especially as building blocks for π-conjugated compounds. The crystal structure of 1,4,5,8-anthracentetrone is reported.

scholarly journals Synthesis of 1,2,5,6- and 1,4,5,8-Anthracenetetrone: Building Blocks for π-Conjugated Small Molecules and Polymers

2018 ◽  
Author(s):  
Florian Glöcklhofer ◽  
Berthold Stöger ◽  
Johannes Fröhlich
Keyword(s):  
Molecular Structure ◽  
Crystal Structure ◽  
Small Molecules ◽  
Organic Synthesis ◽  
Column Chromatography ◽  
Scale Up ◽  
Building Blocks ◽  
Work Load ◽  
Conjugated Compounds ◽  
Work Up

Reliable reactions for the synthesis of two interesting anthracenetetrones have been identified and optimized. Both syntheses start from dihydroxy-9,10-anthraquinones and were selected for maximized efficiency and minimized work load. Work-up of all reactions can be achieved without column chromatography, which facilitates further scale-up. So far, both target compounds are considerably underexplored despite their promising molecular structure for use in devices and in organic synthesis, especially as building blocks for π-conjugated compounds. The crystal structure of 1,4,5,8-anthracentetrone is reported.

Determination of Mg isotope ratios without column chromatography for carbonates using sulphuric acid and MC-ICP-MS

2019 ◽  
Vol 34 (12) ◽  
pp. 2469-2475 ◽  
Author(s):  
Zhian Bao ◽  
Chunlei Zong ◽  
Kangjun Huang ◽  
Kaiyun Chen ◽  
Nan Lv ◽  
...  
Keyword(s):  
Sulphuric Acid ◽  
High Precision ◽  
Column Chromatography ◽  
Isotope Ratios ◽  
Practical Method ◽  
Icp Ms ◽  
Isotope Determination

This study presents a practical method for high-precision Mg isotope determination without column chromatography for carbonate samples using sulphuric acid and MC-ICP-MS.

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