(Z)-Tetrahydrothiophene and (Z)-tetrahydrothiopyran synthesis through nucleophilic substitution and intramolecular cycloaddition of alkynyl halides and EtOCS2K

2019 ◽  
Vol 17 (31) ◽  
pp. 7315-7319 ◽  
Author(s):  
Xianglin Luo ◽  
Yibiao Li ◽  
Xiuwen Chen ◽  
Zhiyan Song ◽  
Junyi Liang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Nucleophilic Substitution ◽  
Thiyl Radical ◽  
Intramolecular Cycloaddition ◽  
Free Condition ◽  
Metal Free ◽  
Novel Method

This protocol provides a novel method for the synthesis of (Z)-tetrahydrothiophene derivatives through the formation of C–S bonds under transition-metal-free condition using thiyl radical intramolecular cycloaddition cascade strategy.

scholarly journals K2S2O8-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2225 ◽  
Author(s):  
Yongjun Bian ◽  
Xingyu Qu ◽  
Yongqiang Chen ◽  
Jun Li ◽  
Leng Liu
Keyword(s):  
Transition Metal ◽  
Functional Groups ◽  
Sulfur Atom ◽  
Coupling Reaction ◽  
Sulfur Source ◽  
Atom Transfer ◽  
Free Condition ◽  
Metal Free ◽  
Aryl Aldehydes ◽  
Three Component Coupling

Thiourea as a sulfur atom transfer reagent was applied for the synthesis of aryl thioamides through a three-component coupling reaction with aryl aldehydes and N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAC). The reaction could tolerate various functional groups and gave moderate to good yields of desired products under the transition-metal-free condition.

scholarly journals Water promoted allylic nucleophilic substitution reactions of (E)-1,3 diphenylallyl acetate

2018 ◽  
Vol 20 (2) ◽  
pp. 425-430 ◽  
Author(s):  
Seema A. Ghorpade ◽  
Dinesh N. Sawant ◽  
Arwa Makki ◽  
Nagaiyan Sekar ◽  
Jörg Eppinger
Keyword(s):  
Transition Metal ◽  
Nucleophilic Substitution ◽  
Allylic Alkylation ◽  
Substitution Reactions ◽  
Allylic Amination ◽  
Metal Free ◽  
Nucleophilic Substitution Reactions ◽  
Water Based

A transition metal free, reagent free, only water based, greener protocol for the allylic alkylation, allylic amination, and O-allylation of (E)-1,3-diphenylallyl acetate is described.

Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride

2018 ◽  
Vol 16 (41) ◽  
pp. 7564-7567 ◽  
Author(s):  
Yibiao Li ◽  
Shuo Huang ◽  
Chunshu Liao ◽  
Yan Shao ◽  
Lu Chen
Keyword(s):  
Transition Metal ◽  
Nucleophilic Substitution ◽  
Efficient Method ◽  
Free Access ◽  
Metal Free ◽  
Catalyst Free ◽  
Hydrolysis Of

Under catalyst-free conditions, an efficient method for the synthesis of 2-aminopyridine derivatives through the nucleophilic substitution and hydrolysis of 2-fluoropyridine and acetamidine hydrochloride has been developed.

Transition-metal-free decarboxylation of dimethyl malonate: an efficient construction of α-amino acid esters using TBAI/TBHP

2015 ◽  
Vol 13 (13) ◽  
pp. 3982-3987 ◽  
Author(s):  
Jie Zhang ◽  
Ying Shao ◽  
Yaxiong Wang ◽  
Huihuang Li ◽  
Dongmei Xu ◽  
...  
Keyword(s):  
Amino Acid ◽  
Transition Metal ◽  
Nucleophilic Substitution ◽  
Amino Acid Esters ◽  
Dimethyl Malonate ◽  
Metal Free ◽  
New Strategy ◽  
Efficient Construction ◽  
Acid Esters

A new strategy has been developed for the synthesis of α-amino acid esters via a tandem hydrolysis/decarboxylation/nucleophilic substitution using TBAI/TBHP.

Transition metal-free access to 3,4-dihydro-1,2-oxaphosphinine-2-oxides from phosphonochloridates and chalcones through tandem Michael addition and nucleophilic substitution

2019 ◽  
Vol 55 (87) ◽  
pp. 13124-13127 ◽  
Author(s):  
Zhicheng Fu ◽  
Simin Sun ◽  
Anjian Yang ◽  
Fang Sun ◽  
Jiaxi Xu
Keyword(s):  
Transition Metal ◽  
Nucleophilic Substitution ◽  
Michael Addition ◽  
Nucleophilic Addition ◽  
Free Access ◽  
Metal Free

3,4-Dihydro-1,2-oxaphosphinine 2-oxides are synthesized through tandem intermolecular nucleophilic addition and cyclization of phosphonochloridates and enones in the presence of base.

NIS-mediated intramolecular oxidative α-functionalization of tertiary amines: transition metal-free synthesis of 1,2-dihydro-(4H)-3,1-benzoxazin-4-one derivatives

RSC Advances ◽  
2015 ◽  
Vol 5 (38) ◽  
pp. 29774-29781 ◽  
Author(s):  
Le Liu ◽  
Liang Du ◽  
Daisy Zhang-Negrerie ◽  
Yunfei Du
Keyword(s):  
Transition Metal ◽  
Bond Formation ◽  
Tertiary Amines ◽  
Metal Free ◽  
Novel Method

A novel method for direct α-functionalization of tertiary amines via NIS-mediated oxidative C–O bond formation, where NIS serves as both an oxidant and an iodination reagent, has been developed.

Synthesis of 1H-1,3-benzimidazoles, benzothiazoles and 3H-imidazo[4,5-c]pyridine using DMF in the presence of HMDS as a reagent under the transition-metal-free condition

2018 ◽  
Vol 72 (12) ◽  
pp. 2973-2978 ◽  
Author(s):  
Hamid Mostafavi ◽  
Mohammad Reza Islami ◽  
Ehsan Ghonchepour ◽  
Ahmad Momeni Tikdari
Keyword(s):  
Transition Metal ◽  
Free Condition ◽  
Metal Free
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