Controlling the regioselectivity of the ring opening of spiro-epoxyoxindoles for efficient synthesis of C(3)–N(1′)-bisindoles and C(3)–N(1′)-diindolylmethane

2019 ◽  
Vol 17 (33) ◽  
pp. 7747-7759 ◽  
Author(s):  
Saumen Hajra ◽  
Subrata Maity ◽  
Sayan Roy ◽  
Dhiraj Das
Keyword(s):  
Ring Opening ◽  
Efficient Synthesis

A strategy for the construction of both C(3)–N(1′) bisindoles and C(3)–N(1′) diindolylmethane has been explored via tuning of the nucleophilicity of indoline/indole to spiro-epoxyoxindole.

Design, synthesis and evaluation of structurally diverse ortho-acylphenol-diindolylmethane hybrids as anticancer agents

2022 ◽  
Author(s):  
Zhi-Gang Yin ◽  
Xiong-Wei Liu ◽  
Hui-Juan Wang ◽  
Min Zhang ◽  
Xiong-Li Liu ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Anticancer Agents ◽  
Nucleophilic Addition ◽  
Ring Opening ◽  
Building Blocks ◽  
Efficient Synthesis ◽  
Design Synthesis ◽  
Pyrone Ring ◽  
Ring Opening Reaction ◽  
First Time

A highly efficient synthesis of structurally diverse ortho-acylphenol–diindolylmethane hybrids 3 using carboxylic acid-activated chromones as versatile synthetic building blocks is reported here for the first time, through 1,4-nucleophilic addition and followed by a decarboxylation and pyrone ring opening reaction process.

Ring opening of benzoxazinones: An improved and efficient synthesis of clavatustides A & B

2017 ◽  
Vol 58 (35) ◽  
pp. 3418-3420
Author(s):  
Suresh Kumar Chettu ◽  
Lakshmi Narayana Sharma Konidena ◽  
Raghu Babu Korupolu ◽  
N.S. Kameswara Rao ◽  
Raju Doddipalla ◽  
...  
Keyword(s):  
Ring Opening ◽  
Efficient Synthesis

ChemInform Abstract: Efficient Synthesis of β-CF3/SCF3-Substituted Carbonyls via Copper-Catalyzed Electrophilic Ring-Opening Cross-Coupling of Cyclopropanols.

ChemInform ◽  
2015 ◽  
Vol 46 (36) ◽  
pp. no-no
Author(s):  
Yong Li ◽  
Zhishi Ye ◽  
Tabitha M. Bellman ◽  
Teng Chi ◽  
Mingji Dai
Keyword(s):  
Ring Opening ◽  
Cross Coupling ◽  
Efficient Synthesis
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