Catalytic asymmetric (4 + 1) annulation of nitroalkenes with allylic acetates: stereoselective synthesis of isoxazoline N-oxides

2019 ◽  
Vol 17 (29) ◽  
pp. 6989-6993 ◽  
Author(s):  
Jinghua Luo ◽  
Rongshun Chen ◽  
Xia Fan ◽  
Junyu Gong ◽  
Jie Han ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Catalytic Asymmetric ◽  
First Time

A highly enantioselective catalytic asymmetric (4 + 1) annulation reaction of nitroalkenes and ammonium ylides is reported for the first time.

Stereoselective synthesis of an eleganine A core

2020 ◽  
Vol 18 (24) ◽  
pp. 4566-4568
Author(s):  
Gints Smits ◽  
Ronalds Zemribo
Keyword(s):  
Stereoselective Synthesis ◽  
Core Structure ◽  
The Core ◽  
First Time

The core structure of eleganine A – a cytotoxic indole monoterpene alkaloid – was accessed for the first time.

Catalytic Asymmetric and Stereoselective Synthesis of Vinylcyclopropanes

Synlett ◽  
2002 ◽  
Vol 2002 (03) ◽  
pp. 0423-0426 ◽  
Author(s):  
Swapan Majumdar ◽  
Armin de Meijere ◽  
Ilan Marek
Keyword(s):  
Stereoselective Synthesis ◽  
Catalytic Asymmetric

Towards the Total Synthesis of Schisandrene: Stereoselective Synthesis of the Dibenzocyclooctadiene Lignan Core

Synlett ◽  
2018 ◽  
Vol 29 (07) ◽  
pp. 908-911 ◽  
Author(s):  
K. Babu ◽  
Arramshetti Venkanna ◽  
Borra Poornima ◽  
Bandi Siva ◽  
B. Babu
Keyword(s):  
Total Synthesis ◽  
Stereoselective Synthesis ◽  
Asymmetric Reduction ◽  
Cross Coupling ◽  
Membered Ring ◽  
Stille Reaction ◽  
Reaction Sequence ◽  
Ring Closing Metathesis ◽  
Synthetic Strategy ◽  
First Time

A stereoselective synthesis of the dibenzocyclooctadiene ­lignan core of the natural product schisandrene is described. Starting from readily available gallic acid, the synthetic strategy involves Suzuki–Miyaura cross-coupling, Stille reaction, and ring-closing metathesis (RCM) in the reaction sequence. The required asymmetric center at C-7′ was established by an asymmetric reduction of a keto compound using the Corey–Bakshi–Shibata (CBS) catalyst. In our approach, the eight-membered ring was achieved by RCM for the first time.

Stereoselective synthesis of fully substituted ethylenes via an Ag-catalyzed 1,6-nucleophilic addition/annulation cascade

2020 ◽  
Vol 56 (56) ◽  
pp. 7749-7752
Author(s):  
Bu-Zheng Tang ◽  
Wen-Juan Hao ◽  
Jia-Zhuo Li ◽  
Shan-Shan Zhu ◽  
Shu-Jiang Tu ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
Stereoselective Synthesis ◽  
First Time

A catalytic 1,6-nucleophilic addition/annulation cascade was developed for the first time, and used to produce 27 hitherto unreported ethylene-linked 1-naphthol-imidazole pairs with generally good yields and complete stereoselectivity.

Catalytic asymmetric [2+2] cycloaddition between quinones and fulvenes and a subsequent stereoselective isomerization to 2,3-dihydrobenzofurans

2017 ◽  
Vol 53 (49) ◽  
pp. 6585-6588 ◽  
Author(s):  
Haifeng Zheng ◽  
Chaoran Xu ◽  
Yan Wang ◽  
Tengfei Kang ◽  
Xiaohua Liu ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Chiral Lewis Acid ◽  
Acid Catalyzed ◽  
Catalytic Asymmetric ◽  
First Time ◽  
Cyclobutane Derivatives

A chiral Lewis acid catalyzed enantioselective [2+2] cycloaddition between quinones and fulvenes was reported for the first time. The method afforded a series of [6,4,5]-tricyclic cyclobutane derivatives in good yields with excellent regio- and stereoselectivities. Furthermore, the [2+2] adducts could be easily converted into formal [3+2] adducts efficiently and stereoselectively.

scholarly journals P(III) vs. P(V): A P(V) Reagent for Thiophosphoramidate Linkages and Application to An Asymmetric Synthesis of a Cyclic Dinucleotide STING Agonist

2021 ◽  
Author(s):  
Bin Zheng ◽  
Chao Hang ◽  
Jason Zhu ◽  
Geoffrey Purdum ◽  
Melda Sezen-Edmonds ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Functional Groups ◽  
Stereoselective Synthesis ◽  
Key Functional Groups ◽  
First Time ◽  
Cyclic Dinucleotide

A highly stereoselective synthesis of a cyclic dinucleotide (CDN) STING agonist containing two chiral thiophosphoramidate linkages is described. These rare, yet key functional groups were, for the first time, installed efficiently and with high diastereoselectivity using a specially designed P(V) reagent. By utilizing this strategy, the CDN was prepared in greater than sixteen-fold higher yield than the prior P(III) approach, with fewer hazardous reagents and chromatographic purifications.

Sign in / Sign up

Export Citation Format

Share Document