scholarly journals Catalytic asymmetric aza-Michael addition of fumaric monoacids with multifunctional thiourea/boronic acids

2019 ◽  
Vol 17 (9) ◽  
pp. 2331-2335 ◽  
Author(s):  
Kenichi Michigami ◽  
Hiroki Murakami ◽  
Takeru Nakamura ◽  
Noboru Hayama ◽  
Yoshiji Takemoto
Keyword(s):  
Michael Addition ◽  
Boronic Acid ◽  
Boronic Acids ◽  
Acid Catalysts ◽  
Catalytic Asymmetric

Chiral multifunctional thiourea/boronic acid catalysts enabled the synthesis of N-hydroxyaspartate derivatives applicable for KAHA amidation through acid-β selective aza-Michael addition.

ChemInform Abstract: Catalytic Asymmetric Michael Addition of Nitromethane to Enones Controlled by (R)-LPB.

ChemInform ◽  
2010 ◽  
Vol 29 (52) ◽  
pp. no-no
Author(s):  
K. FUNABASHI ◽  
Y. SAIDA ◽  
M. KANAI ◽  
T. ARAI ◽  
H. SASAI ◽  
...  
Keyword(s):  
Michael Addition ◽  
Asymmetric Michael Addition ◽  
Catalytic Asymmetric

Formation of Optically Active Chromans by Catalytic Asymmetric Tandem Oxa-Michael Addition—Friedel—Crafts Alkylation Reactions.

ChemInform ◽  
2003 ◽  
Vol 34 (39) ◽  
Author(s):  
Hester L. van Lingen ◽  
Wei Zhuang ◽  
Tore Hansen ◽  
Floris P. J. T. Rutjes ◽  
Karl Anker Joergensen
Keyword(s):  
Michael Addition ◽  
Optically Active ◽  
Catalytic Asymmetric ◽  
Alkylation Reactions

Catalytic Asymmetric Michael Addition of 1,3-Dicarbonyls to Nitroalkenes

2020 ◽  
pp. 7-41
Author(s):  
Irishi N. N. Namboothiri ◽  
Meeta Bhati ◽  
Madhu Ganesh ◽  
Basavaprabhu Hosamani ◽  
Thekke V. Baiju ◽  
...  
Keyword(s):  
Michael Addition ◽  
Asymmetric Michael Addition ◽  
Catalytic Asymmetric

scholarly journals A Theoretical Model to Study the Interaction Between Boronic Acids and Insulin

2020 ◽  
Author(s):  
Durgesh Kumar ◽  
Kamlesh Kumari ◽  
PRASHANT SINGH
Keyword(s):  
Amino Acids ◽  
Theoretical Model ◽  
Boronic Acid ◽  
Significant Interaction ◽  
Biological Activities ◽  
Boronic Acids ◽  
Biological Molecules ◽  
Computational Tools ◽  
Medical Expertise ◽  
Stabilizing Agents

Boronic acids are widely used in various applications in view of their ability to recognize and bind at specific sites of the biological molecules to mimic several processes. Therefore, this has attracted the researchers, academician and medical expertise to explore them. In the present work, the authors have designed a theoretical approach to study the interaction of boronic acid with insulin using computational tools. A library of boronic acids (114 compounds) are designed, optimized and interacted with insulin using computational tools i.e. iGEMDOCK. Further, their different biological activities and toxicity are determined. Results indicates the promising potential of the boronic acids on interaction with the insulin. Amongst, 114 molecules of boronic acids, 3-Benzyloxyphenylboronic acid (71) showed the best interaction with amino-acids of insulin and significant interaction was shown with the Glu21 and His5 residues. Further, these results were compared with the stabilizing agents and found to be more potent.

(DPEPhos)Ni(mesityl)Br: An Air-Stable Pre-Catalyst for Challenging Suzuki–Miyaura Cross-Couplings Leading to Unsymmetrical Biheteroaryls

Synlett ◽  
2018 ◽  
Vol 29 (06) ◽  
pp. 799-804 ◽  
Author(s):  
Mark Stradiotto ◽  
Ryan Sawatzky
Keyword(s):  
Boronic Acid ◽  
Cross Coupling ◽  
Boronic Acids ◽  
Mild Conditions

The successful application of (DPEPhos)Ni(mesityl)Br (C1) as a pre-catalyst in the Suzuki–Miyaura cross-coupling of heteroaryl chlorides or bromides and heteroaryl boronic acids is reported. The use of C1 in this context allows for such reactions to be conducted under mild conditions (2 mol% Ni, 25 °C), including cross-couplings leading to unsymmetrical biheteroaryls. Successful transformations of this type involving problematic pyridinyl boronic acid substrates (10 mol% Ni, 60 °C) are also described.

Catalytic Asymmetric Construction of Spirocyclopentaneoxindoles by a Combined Ru-Catalyzed Cross-Metathesis/Double Michael Addition Sequence

2011 ◽  
Vol 13 (23) ◽  
pp. 6200-6203 ◽  
Author(s):  
Ying-Mei Li ◽  
Xiang Li ◽  
Fang-Zhi Peng ◽  
Ze-Qian Li ◽  
Shou-Tao Wu ◽  
...  
Keyword(s):  
Michael Addition ◽  
Cross Metathesis ◽  
Catalytic Asymmetric

The design of a spiro-pyrrolidine organocatalyst and its application to catalytic asymmetric Michael addition for the construction of all-carbon quaternary centers

2015 ◽  
Vol 51 (49) ◽  
pp. 9979-9982 ◽  
Author(s):  
Jin-Miao Tian ◽  
Yong-Hai Yuan ◽  
Yong-Qiang Tu ◽  
Fu-Min Zhang ◽  
Xiao-Bo Zhang ◽  
...  
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Silyl Ether ◽  
Michael Addition Reaction ◽  
Quaternary Centers ◽  
Asymmetric Michael Addition ◽  
Catalytic Asymmetric

A novel chiral spiro-pyrrolidine silyl ether organocatalyst has been designed and applied to an asymmetric Michael addition reaction.

Direct Catalytic Asymmetric Doubly Vinylogous Michael Addition of α,β-Unsaturated γ-Butyrolactams to Dienones

2015 ◽  
Vol 127 (35) ◽  
pp. 10387-10391 ◽  
Author(s):  
Xiaodong Gu ◽  
Tingting Guo ◽  
Yuanyuan Dai ◽  
Allegra Franchino ◽  
Jie Fei ◽  
...  
Keyword(s):  
Michael Addition ◽  
Catalytic Asymmetric

scholarly journals Carbonylative Suzuki–Miyaura couplings of sterically hindered aryl halides: synthesis of 2-aroylbenzoate derivatives

2020 ◽  
Vol 18 (9) ◽  
pp. 1754-1759 ◽  
Author(s):  
Aya Ismael ◽  
Troels Skrydstrup ◽  
Annette Bayer
Keyword(s):  
Boronic Acid ◽  
Boronic Acids ◽  
Aryl Halides ◽  
Aryl Bromides ◽  
Sterically Hindered

A new protocol for carbonylative coupling of sterically hindered aryl bromides with boronic acids featuring slow addition of the boronic acid as a strategy to suppress unwanted non-carbonylative couplings for sterically hindered aryl bromides.

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