RGD functionalized chitosan nanoparticle mediated targeted delivery of raloxifene selectively suppresses angiogenesis and tumor growth in breast cancer

Nanoscale ◽  
2020 ◽  
Vol 12 (19) ◽  
pp. 10664-10684 ◽  
Author(s):  
Amit S. Yadav ◽  
N. Naga Venkata Radharani ◽  
Mahadeo Gorain ◽  
Anuradha Bulbule ◽  
Dattatrya Shetti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Targeted Delivery ◽  
Chitosan Nanoparticles ◽  
Ph Sensitive ◽  
Inhibit Tumor Growth ◽  
Chitosan Nanoparticle

Peptide functionalized pH sensitive raloxifene-chitosan nanoparticles with high biocompatibility synergistically inhibit tumor growth and angiogenesis in breast cancer.

scholarly journals G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer

2020 ◽  
Vol 180 (3) ◽  
pp. 635-646 ◽  
Author(s):  
Kaitlyn J. Andreano ◽  
Suzanne E. Wardell ◽  
Jennifer G. Baker ◽  
Taylor K. Desautels ◽  
Robert Baldi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Animal Models ◽  
Tumor Growth ◽  
Inhibit Tumor Growth

scholarly journals Tocotrienol-Adjuvanted Dendritic Cells Inhibit Tumor Growth and Metastasis: A Murine Model of Breast Cancer

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74753 ◽  
Author(s):  
Sitti Rahma Abdul Hafid ◽  
Srikumar Chakravarthi ◽  
Kalanithi Nesaretnam ◽  
Ammu Kutty Radhakrishnan
Keyword(s):  
Breast Cancer ◽  
Dendritic Cells ◽  
Tumor Growth ◽  
Murine Model ◽  
Inhibit Tumor Growth ◽  
Tumor Growth And Metastasis

scholarly journals Novel antiangiogenic peptides inhibit tumor growth in breast cancer xenografts

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Jacob E Koskimaki ◽  
Elena Rosca ◽  
Venu Raman ◽  
Zaver Bhujwalla ◽  
Aleksander Popel
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Inhibit Tumor Growth ◽  
Breast Cancer Xenografts

scholarly journals Magnetic Alginate / Chitosan Nanoparticles for Targeted Delivery of Curcumin into Human Breast Cancer Cells

2018 ◽  
Author(s):  
Wenxing Song ◽  
Xing Su ◽  
David Gregory ◽  
Wei Li ◽  
Zhiqiang Cai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Breast Cancer Cells ◽  
Chitosan Nanoparticles ◽  
Cancer Drug ◽  
Uptake Efficiency ◽  
Anti Cancer ◽  
Hdf Cells

Curcumin is a promising anti-cancer drug but its applications in cancer therapy are limited due to its poor solubility, short half-life and low bioavailability. In this study, curcumin loaded magnetic alginate / chitosan nanoparticles were fabricated to improve the bioavailability, uptake efficiency and cytotoxicity of curcumin to MDA-MB-231 breast cancer cells. Alginate and chitosan were deposited on Fe3O4 magnetic nanoparticles based on their electrostatic properties. The sizes of the nanoparticles (120-200 nm) were within the optimum range for drug delivery. Sustained curcumin release was obtained use the nanoparticles with the ability to control the curcumin release rate by altering the number of chitosan and alginate layers. Confocal fluorescence microscopy results showed that targeted delivery of curcumin with the aid of magnetic field were achieved. The FACS assay indicated that MDA-MB-231 cells treated with curcumin loaded nanoparticles had a 3-6 folds uptake efficiency to those treated with free curcumin. MTT assay indicated that the curcumin loaded nanoparticles exhibited significantly higher cytotoxicity toward MDA-MB-231 cells than toward HDF cells. The sustained release profiles, enhanced uptake efficiency and cytotoxicity to cancer cells as well as the targeting potential make MACPs a promising candidate for cancer therapy.

scholarly journals Targeted delivery of let-7a microRNA encapsulated ephrin-A1 conjugated liposomal nanoparticles inhibit tumor growth in lung cancer

2013 ◽  
pp. 4481 ◽  
Author(s):  
Najmunnisa Nasreen ◽  
Hung-yen Lee ◽  
Kamal Mohammed ◽  
Frederic Kaye ◽  
Parvesh Sharma ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Growth ◽  
Targeted Delivery ◽  
Inhibit Tumor Growth ◽  
Liposomal Nanoparticles

Hollow chitosan–silica nanospheres as pH-sensitive targeted delivery carriers in breast cancer therapy

Biomaterials ◽  
2011 ◽  
Vol 32 (21) ◽  
pp. 4976-4986 ◽  
Author(s):  
Ziwei Deng ◽  
Zipeng Zhen ◽  
Xiaoxi Hu ◽  
Shuilin Wu ◽  
Zushun Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Ph Sensitive ◽  
Silica Nanospheres ◽  
Breast Cancer Therapy
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