Eliciting an immune hot tumor niche with biomimetic drug-based multi-functional nanohybrids augments immune checkpoint blockade-based breast cancer therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 3317-3329 ◽  
Author(s):  
Wei Du ◽  
Chen Chen ◽  
Peng Sun ◽  
Shengchang Zhang ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Immune Checkpoint ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
Breast Cancer Therapy

Biomimetic drug-based nanohybrids boost immune checkpoint blockade-based cancer therapy through eliciting an immune hot tumor niche.

scholarly journals Immune Checkpoint Blockade in HER2-Positive Breast Cancer: What Role in Early Disease Setting?

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1655
Author(s):  
Cinzia Solinas ◽  
Debora Fumagalli ◽  
Maria Vittoria Dieci
Keyword(s):  
Breast Cancer ◽  
Immune Checkpoint ◽  
Neoadjuvant Treatment ◽  
Tumor Infiltrating Lymphocytes ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
Current Evidence ◽  
Her2 Positive ◽  
Her2 Positive Breast Cancer ◽  
Positive Breast Cancer

The present commentary synthesizes the current evidence on the role of the immune response in HER2-positive breast cancer. It points out the strengths and weaknesses of the findings observed so far, particularly in the early setting, including the clinical significance of scoring tumor-infiltrating lymphocytes. A figure proposing research hypotheses for the implementation of immune checkpoint blockade use for patient candidates to neoadjuvant treatment is presented.

scholarly journals Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy

2016 ◽  
Vol 16 (5) ◽  
pp. 275-287 ◽  
Author(s):  
Suzanne L. Topalian ◽  
Janis M. Taube ◽  
Robert A. Anders ◽  
Drew M. Pardoll
Keyword(s):  
Cancer Therapy ◽  
Immune Checkpoint ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade

scholarly journals Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer

2020 ◽  
Vol 39 (1) ◽  
Author(s):  
Simona Camorani ◽  
Margherita Passariello ◽  
Lisa Agnello ◽  
Silvia Esposito ◽  
Francesca Collina ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapy ◽  
Triple Negative Breast Cancer ◽  
Immune Checkpoint ◽  
Triple Negative ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade

scholarly journals Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor

Theranostics ◽  
2019 ◽  
Vol 9 (19) ◽  
pp. 5542-5557 ◽  
Author(s):  
Zeqian Huang ◽  
Gaofei Wei ◽  
Zishan Zeng ◽  
Yanjuan Huang ◽  
Liangfeng Huang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Immune Checkpoint ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade
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