scholarly journals Four-wave-mixing microscopy reveals non-colocalisation between gold nanoparticles and fluorophore conjugates inside cells

Nanoscale ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 4622-4635
Author(s):  
Naya Giannakopoulou ◽  
Joseph B. Williams ◽  
Paul R. Moody ◽  
Edward J. Sayers ◽  
Johannes P. Magnusson ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Optical Microscopy ◽  
Four Wave Mixing ◽  
Wave Mixing

Novel four-wave mixing optical microscopy detects single gold nanoparticles background-free inside cells and reveals non-colocalisation with fluorophore conjugates.

scholarly journals Optical micro-spectroscopy of single metallic nanoparticles: quantitative extinction and transient resonant four-wave mixing

2015 ◽  
Vol 184 ◽  
pp. 305-320 ◽  
Author(s):  
Lukas Payne ◽  
George Zoriniants ◽  
Francesco Masia ◽  
Kenton P. Arkill ◽  
Paul Verkade ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Four Wave Mixing ◽  
Particle Analysis ◽  
Imaging Method ◽  
Wide Field ◽  
Wave Mixing ◽  
Extinction Cross Section ◽  
Optical Extinction ◽  
Aspect Ratios ◽  
Sensing Applications

We report a wide-field imaging method to rapidly and quantitatively measure the optical extinction cross-section σext (also polarisation resolved) of a large number of individual gold nanoparticles, for statistically-relevant single particle analysis. We demonstrate a sensitivity of 5 nm2 in σext, enabling detection of single 5 nm gold nanoparticles with total acquisition times in the 1 min range. Moreover, we have developed an analytical model of the polarisation resolved σext, which enabled us to extract geometrical particle aspect ratios from the measured σext. Using this method, we have characterized a large number of nominally-spherical gold nanoparticles in the 10–100 nm size range. Furthermore, the method provided measurements of in-house fabricated nanoparticle conjugates, allowing distinction of individual dimers from single particles and larger aggregates. The same particle conjugates were investigated correlatively by phase-resolved transient resonant four-wave mixing micro-spectroscopy. A direct comparison of the phase-resolved response between single gold nanoparticles and dimers highlighted the promise of the four-wave mixing technique for sensing applications with dimers as plasmon rulers.

scholarly journals Background-free 3D four-wave mixing microscopy of single gold nanoparticles inside biological systems

2021 ◽  
Author(s):  
Iestyn Pope ◽  
Nuno G. C. Ferreira ◽  
Yisu Wang ◽  
Francesco Masia ◽  
Karl Swann ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Biological Systems ◽  
Four Wave Mixing ◽  
Wave Mixing

Triply surface-plasmon resonant four-wave mixing imaging of gold nanoparticles

2011 ◽  
Author(s):  
Francesco Masia ◽  
Wolfgang Langbein ◽  
Peter Watson ◽  
Paola Borri
Keyword(s):  
Gold Nanoparticles ◽  
Surface Plasmon ◽  
Four Wave Mixing ◽  
Wave Mixing ◽  
Surface Plasmon Resonant

scholarly journals Nonlinear coherent four-wave mixing in optical microscopy

2000 ◽  
Vol 17 (10) ◽  
pp. 1678 ◽  
Author(s):  
Eric O. Potma ◽  
Wim P. de Boeij ◽  
Douwe A. Wiersma
Keyword(s):  
Optical Microscopy ◽  
Four Wave Mixing ◽  
Wave Mixing

Resonant four-wave mixing of gold nanoparticles for three-dimensional cell microscopy

2009 ◽  
Vol 34 (12) ◽  
pp. 1816 ◽  
Author(s):  
Francesco Masia ◽  
Wolfgang Langbein ◽  
Peter Watson ◽  
Paola Borri
Keyword(s):  
Gold Nanoparticles ◽  
Three Dimensional ◽  
Four Wave Mixing ◽  
Wave Mixing ◽  
Cell Microscopy ◽  
Dimensional Cell
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