scholarly journals Ultrabright fluorescent silica nanoparticles for in vivo targeting of xenografted human tumors and cancer cells in zebrafish

Nanoscale ◽  
2019 ◽  
Vol 11 (46) ◽  
pp. 22316-22327 ◽  
Author(s):  
Saquib Ahmed M. A. Peerzade ◽  
Xiaodan Qin ◽  
Fabrice J. F. Laroche ◽  
Shajesh Palantavida ◽  
Maxim Dokukin ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Human Tumors ◽  
Fluorescent Silica Nanoparticles

New ultrabright fluorescent silica nanoparticles for targeting cancers in vivo are presented.

scholarly journals In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish

10.3791/61187 ◽  
2020 ◽  
Author(s):  
Xiaodan Qin ◽  
Fabrice F. J. Laroche ◽  
Saquib Ahmed M. A. Peerzade ◽  
Andrew Lam ◽  
Igor Sokolov ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Fluorescent Silica Nanoparticles

scholarly journals Dye-Doped Fluorescent Silica Nanoparticles for Live Cell and In Vivo Bioimaging

Nanomaterials ◽  
2016 ◽  
Vol 6 (5) ◽  
pp. 81 ◽  
Author(s):  
Wen-Han Zhang ◽  
Xiao-Xiao Hu ◽  
Xiao-Bing Zhang
Keyword(s):  
Silica Nanoparticles ◽  
Live Cell ◽  
Fluorescent Silica Nanoparticles

Cetuximab-conjugated magneto-fluorescent silica nanoparticles for in vivo colon cancer targeting and imaging

2010 ◽  
Vol 299 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Young-Seok Cho ◽  
Tae-Jong Yoon ◽  
Eue-Soon Jang ◽  
Kwan Soo Hong ◽  
Shin Young Lee ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Silica Nanoparticles ◽  
Cancer Targeting ◽  
Fluorescent Silica Nanoparticles

In Vivo Imaging of Sentinel Nodes Using Fluorescent Silica Nanoparticles in Living Mice

2009 ◽  
Vol 12 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Yong Hyun Jeon ◽  
Young-Hwa Kim ◽  
Kihwan Choi ◽  
Jing Yu Piao ◽  
Bo Quan ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
In Vivo Imaging ◽  
Sentinel Nodes ◽  
Fluorescent Silica Nanoparticles

scholarly journals Direct Transfer of Mesoporous Silica Nanoparticles between Macrophages and Cancer Cells

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2892
Author(s):  
Stefan Franco ◽  
Achraf Noureddine ◽  
Jimin Guo ◽  
Jane Keth ◽  
Michael L. Paffett ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Nano Scale ◽  
Cervical Cancer Cells ◽  
Cytoplasmic Bridges ◽  
4T1 Breast Cancer

Macrophages line the walls of microvasculature, extending processes into the blood flow to capture foreign invaders, including nano-scale materials. Using mesoporous silica nanoparticles (MSNs) as a model nano-scale system, we show the interplay between macrophages and MSNs from initial uptake to intercellular trafficking to neighboring cells along microtubules. The nature of cytoplasmic bridges between cells and their role in the cell-to-cell transfer of nano-scale materials is examined, as is the ability of macrophages to function as carriers of nanomaterials to cancer cells. Both direct administration of nanoparticles and adoptive transfer of nanoparticle-loaded splenocytes in mice resulted in abundant localization of nanomaterials within macrophages 24 h post-injection, predominately in the liver. While heterotypic, trans-species nanomaterial transfer from murine macrophages to human HeLa cervical cancer cells or A549 lung cancer cells was robust, transfer to syngeneic 4T1 breast cancer cells was not detected in vitro or in vivo. Cellular connections and nanomaterial transfer in vivo were rich among immune cells, facilitating coordinated immune responses.

Tracking mesenchymal stem cell tumor-homing using fluorescent silica nanoparticles

2015 ◽  
Vol 3 (7) ◽  
pp. 1245-1253 ◽  
Author(s):  
Yu Gao ◽  
Yaqi Wang ◽  
Afu Fu ◽  
Wei Shi ◽  
David Yeo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Silica Nanoparticles ◽  
Human Mesenchymal Stem Cells ◽  
Cell Tumor ◽  
Core Shell ◽  
Fluorescent Silica Nanoparticles ◽  
Tumor Tropism ◽  
Tumor Homing

Core–shell fluorescent silica nanoparticles for in vitro and in vivo tracking of tumor tropism of human mesenchymal stem cells.

scholarly journals Antibody-pHPMA functionalised fluorescent silica nanoparticles for colorectal carcinoma targeting

RSC Advances ◽  
2018 ◽  
Vol 8 (39) ◽  
pp. 21679-21689 ◽  
Author(s):  
Denisa Lizoňová ◽  
Monika Majerská ◽  
Vlastimil Král ◽  
Michal Pechar ◽  
Robert Pola ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Carbonic Anhydrase ◽  
Colorectal Carcinoma ◽  
Silica Nanoparticles ◽  
Tumour Cells ◽  
Carbonic Anhydrase Ix ◽  
Fluorescent Silica Nanoparticles

Nanoparticles functionalised with pHPMA and monoclonal antibody IgG M75 show specific adhesion to tumour cells expressing carbonic anhydrase IX bothin vitroandin vivo.

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