A single nanowire sensor for intracellular glucose detection

Nanoscale ◽  
2019 ◽  
Vol 11 (22) ◽  
pp. 10702-10708 ◽  
Author(s):  
Quan-Lan Liao ◽  
Hong Jiang ◽  
Xin-Wei Zhang ◽  
Quan-Fa Qiu ◽  
Yun Tang ◽  
...  
Keyword(s):  
Electrochemical Sensor ◽  
Glucose Detection ◽  
Single Nanowire ◽  
Glucose Levels ◽  
Nanowire Sensor ◽  
First Time ◽  
Intracellular Glucose

We report for the first time the development of a single nanowire electrochemical sensor for the detection of intracellular glucose levels.

A novel electrochemical sensor for glucose detection based on Ag@ZIF-67 nanocomposite

2018 ◽  
Vol 260 ◽  
pp. 852-860 ◽  
Author(s):  
Wei Meng ◽  
Yuanyuan Wen ◽  
Lei Dai ◽  
Zhangxing He ◽  
Ling Wang
Keyword(s):  
Electrochemical Sensor ◽  
Glucose Detection

Development of hyperinsulinemia and insulin resistance during the early stage of weight gain

2008 ◽  
Vol 294 (3) ◽  
pp. E568-E575 ◽  
Author(s):  
Johannes Erdmann ◽  
Bianca Kallabis ◽  
Ulrich Oppel ◽  
Oleg Sypchenko ◽  
Stefan Wagenpfeil ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Secretion ◽  
Weight Gain ◽  
Early Stage ◽  
Normal Range ◽  
Intravenous Glucose ◽  
C Peptide ◽  
Glucose Levels ◽  
Hyperglycemic Clamp ◽  
First Time

Obesity is associated with insulin resistance and hyperinsulinemia, which is considered to be a core component in the pathophysiology of obesity-related comorbidities. As yet it is unknown whether insulin resistance and hyperinsulinemia already develop during weight gain within the normal range. In 10 healthy male subjects the effect of intentional weight gain by 2 BMI points was examined on insulin. C-peptide and glucose levels following a meal, 75 g of glucose, and a two-step hyperglycemic clamp increased plasma glucose by 1.38 and 2.75 mmol/l, respectively. Baseline insulin, C-peptide, and glucose concentrations were significantly higher after weight gain from 21.8 to 23.8 kg/m2 BMI within 41/2 mo. Calculations of insulin secretion and clearance indicate that reduced insulin clearance contributes more to post-weight gain basal hyperinsulinemia than insulin secretion. Following oral or intravenous stimulation insulin concentrations were significantly higher post-weight gain during all three test conditions, whereas C-peptide and glucose levels did not differ. Calculations of insulin secretion and clearance demonstrated that higher stimulated insulin concentrations are entirely due to clearance but not secretion. Despite significantly higher insulin levels, the rate of intravenous glucose required to maintain the defined elevation of glucose levels was either identical (1.38 mmol/l) or even significantly lower (2.75 mmol/l) following weight gain. The present study demonstrates for the first time that insulin resistance already develops during weight gain within the normal range of body weight. The associated basal and stimulated hyperinsulinemia is the result of differentiated changes of insulin secretion and clearance, respectively.

A high-performance Co-MOF non-enzymatic electrochemical sensor for glucose detection

2021 ◽  
Author(s):  
Zhen-Zhen Ma ◽  
Yao Ma ◽  
Bing Liu ◽  
Ling Xu ◽  
Huan Jiao
Keyword(s):  
Electrochemical Sensor ◽  
Terephthalic Acid ◽  
High Performance ◽  
Metal Organic Frameworks ◽  
Deep Eutectic Solvents ◽  
Cobalt Metal ◽  
Glucose Detection ◽  
Metal Organic

Two cobalt metal-organic frameworks (Co-MOFs), [Ch]2[Co3(BDC)3Cl2] (1) and [Ch]2[Co3(BDC)4]·2DMU (2) (Ch+ = choline cation; H2BDC = terephthalic acid; DMU = 1,3-dimethylurea), were prepared through ionothermal reactions with deep eutectic solvents...

Highly sensitive and selective non-enzymatic glucose detection based on indigo carmine/hemin/H2O2 chemiluminescence

The Analyst ◽  
2020 ◽  
Vol 145 (3) ◽  
pp. 1041-1046 ◽  
Author(s):  
Tadesse Haile Fereja ◽  
Shimeles Addisu Kitte ◽  
Muhammad Nadeem Zafar ◽  
Mohamed Ibrahim Halawa ◽  
Shuang Han ◽  
...  
Keyword(s):  
Indigo Carmine ◽  
Glucose Detection ◽  
Highly Sensitive ◽  
Enzymatic Detection ◽  
First Time

Chemiluminescence of indigo carmine/glucose/hemin/H2O2 has been reported for the first time, and used for sensitive non-enzymatic detection of glucose and indigo carmine.

scholarly journals Experience affects exercise-induced changes in catecholamines, glucose, and FFA

1989 ◽  
Vol 256 (1) ◽  
pp. R169-R173 ◽  
Author(s):  
A. J. Scheurink ◽  
A. B. Steffens ◽  
G. H. Dreteler ◽  
L. Benthem ◽  
R. Bruntink
Keyword(s):  
Metabolic Response ◽  
Plasma Catecholamines ◽  
Plasma Free Fatty Acid ◽  
Blood Component ◽  
Experimental Conditions ◽  
Glucose Levels ◽  
Exercise Induced ◽  
Induced Changes ◽  
Response To Exercise ◽  
First Time

The interference of the experimental conditions on the exercise-induced alterations in plasma catecholamines, plasma free fatty acids, and glucose and insulin concentrations was investigated in rats. Exercise consisted of strenuous swimming against a countercurrent (0.22 m/s) for 15 min in a pool with water of 33 degrees C. Before, during, and after swimming, blood samples were taken through a permanent heart catheter. The blood component levels in rats that were confronted with exercise for the very first time were compared with the levels in rats that were well accustomed to the exercise conditions. The very first time rats swam caused an enhanced release of epinephrine from the adrenal medulla and a reduced output of norepinephrine from the sympathetic nerve endings. Furthermore, in the first time swim group, blood glucose levels were higher and plasma free fatty acid concentrations were lower compared with the well-accustomed animals. There were no differences in plasma insulin concentrations. It is concluded that the experimental conditions may interfere considerably with the hormonal and metabolic response to exercise. Furthermore the results reinforce the idea that the two parts of the sympathoadrenal system are functionally and metabolically dissociated.

scholarly journals Characterisation of Glucose-Dependent Insulinotropic Polypeptide Receptor Antagonists in Rodent Pancreatic Beta Cells and Mice

2019 ◽  
Vol 12 ◽  
pp. 117955141987545 ◽  
Author(s):  
RA Perry ◽  
SL Craig ◽  
MT Ng ◽  
VA Gault ◽  
PR Flatt ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Pancreatic Beta Cells ◽  
Receptor Activation ◽  
Contributing Factors ◽  
Glucose Lowering ◽  
Incretin Hormone ◽  
Glucose Levels ◽  
First Time ◽  
Gip Receptor

Hypersecretion and alterations in the biological activity of the incretin hormone, glucose-dependent insulinotropic polypeptide (GIP), have been postulated as contributing factors in the development of obesity-related diabetes. However, recent studies also point to weight-reducing effects of GIP receptor activation. Therefore, generating precise experimental tools, such as specific and effective GIP receptor (GIPR) antagonists, is of key significance to better understand GIP physiology. Thus, the primary aim of the current study was to uncover improved GIPR antagonists for use in rodent studies, using human and mouse GIP sequences with N- and C-terminal deletions. Initial in vitro studies revealed that the GIPR agonists, human (h) GIP(1-42), hGIP(1-30) and mouse (m) GIP(1-30), stimulated ( P < 0.01 to P < 0.001) insulin secretion from rat BRIN-BD11 cells. Analysis of insulin secretory effects of the N- and C-terminally cleaved GIP peptides, including hGIP(3-30), mGIP(3-30), h(Pro3)GIP(3-30), hGIP(5-30), hGIP(3-42) and hGIP(5-42), revealed that these peptides did not modulate insulin secretion. More pertinently, only hGIP(3-30), mGIP(3-30) and h(Pro3)GIP(3-30) were able to significantly ( P < 0.01 to P < 0.001) inhibit hGIP(1-42)-stimulated insulin secretion. The human-derived GIPR agonist sequences, hGIP(1-42) and hGIP(1-30), reduced ( P < 0.05) glucose levels in mice following conjoint injection with glucose, but mGIP(1-30) was ineffective. None of the N- and C-terminally cleaved GIP peptides affected glucose homeostasis when injected alone with glucose. However, hGIP(5-30) and mGIP(3-30) significantly ( P < 0.05 to P < 0.01) impaired the glucose-lowering action of hGIP(1-42). Further evaluation of these most effective sequences demonstrated that mGIP(3-30), but not hGIP(5-30), effectively prevented GIP-induced elevations of plasma insulin concentrations. These data highlight, for the first time, that mGIP(3-30) represents an effective molecule to inhibit GIPR activity in mice.

Hierarchical core–shell structured Ni3S2/NiMoO4 nanowires: a high-performance and reusable electrochemical sensor for glucose detection

The Analyst ◽  
2019 ◽  
Vol 144 (16) ◽  
pp. 4925-4934 ◽  
Author(s):  
Palanisamy Kannan ◽  
Fangshuai Chen ◽  
Huasheng Jiang ◽  
Hui Wang ◽  
Rongfang Wang ◽  
...  
Keyword(s):  
Electrochemical Sensor ◽  
High Performance ◽  
Core Shell ◽  
Glucose Detection ◽  
Electro Oxidation ◽  
Oxidation Of Glucose

The electro-oxidation of glucose occurred at the surface of hierarchical core–shell Ni3S2/NiMoO4 nanowires.

Non-enzymatic glucose detection using nitrogen-doped diamond-like carbon electrodes modified with gold nanoclusters

2010 ◽  
Vol 82 (11) ◽  
pp. 2217-2229 ◽  
Author(s):  
Aiping Liu ◽  
Erjia Liu ◽  
Guocheng Yang ◽  
Nay Win Khun ◽  
Wenguang Ma
Keyword(s):  
Photoelectron Spectroscopy ◽  
Gold Nanoclusters ◽  
High Sensitivity ◽  
Vacuum Arc ◽  
Diabetic Patients ◽  
Diamond Like Carbon ◽  
Glucose Detection ◽  
Detection Range ◽  
Nitrogen Doped ◽  
Glucose Levels

Highly sensitive electrochemical electrodes for glucose detection were developed by using Au nanoclusters (NCs) to modify nitrogen-doped diamond-like carbon thin films (DLC:N/Au). The DLC:N/Au electrodes were prepared with a filtered cathodic vacuum arc process followed by electrodeposition and characterized by X-ray photoelectron spectroscopy, Raman spectroscopy, and scanning electron microscopy. The size of the Au NCs covered by Au oxide ranged between 10 and 70 nm with a density of 108–109 clusters per cm2. Glucose oxidation at the DLC:N/Au electrodes started from about –0.5 V due to the high catalytic activities of the Au NCs in NaOH solutions, and the catalytic ability of the electrodes depended on the amount of Au NCs deposited on the electrode surfaces. A linear detection range of glucose with the DLC:N/Au electrodes was identified from about 0.25 to 30 mM (covering blood glucose levels in diabetic patients) with a detection limit of 60 μM. The experimental results showed that the non-enzymatic glucose sensors based on the DLC:N/Au electrodes had high sensitivity and good reproducibility and stability.

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